Novel morphology change of Au-Methotrexate conjugates: From nanochains to discrete nanoparticles

Wang, Weiyuan; Zhao, Xiu-Fen; Ju, Xiao-Han; Wang, Yu; Wang, Lin; Li, Shuping

doi:10.1016/j.ijpharm.2016.10.022

Cited by 12 publications

(18 citation statements)

References 55 publications

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“…Therefore, in order to better understand the interactions between BC and CMC, BC/CMC biocomposites with different DS were prepared in this work by in situ modification of a static culture medium using Gluconacetobacter bacteria. MTX, a poorly water soluble-drug traditionally used in the treatment of cancer, inflammatory and autoimmune diseases (Wang et al, 2016) was incorporated to the BC/CMC membranes in order to optimize the topical treatment of psoriasis, an autoimmune disorder of skin characterized by hiperkeratosis and inflammation (Boakye et al, 2017), as shown in Scheme 1.…”

Section: Introductionmentioning

confidence: 99%

Effect of in situ modification of bacterial cellulose with carboxymethylcellulose on its nano/microstructure and methotrexate release properties

Fontes

Meneguin

Tercjak

et al. 2018

Carbohydrate Polymers

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Bacterial cellulose/carboxymethylcelullose (BC/CMC) biocomposites with different DS-CMC (DS from 0.7 to 1.2) were developed in order to evaluate their impact as a drug delivery system. Biocomposites were loaded with methotrexate (MTX) as an alternative for the topical treatment of psoriasis. Scanning electron microscopy and atomic force microscopy showed that the CMC coated the cellulose nanofibers, leading to the decrease of the elastic modulus as the DS of CMC increased. BC/CMC0.9 exhibited the lower liquid uptake (up to 11 times lower), suggesting that the more linear structure of the intermediate substitute CMC grade (0.9) was able to interact more strongly with BC, resulting in a denser structure. All samples showed a typical burst release effect in the first 15min of test, however the BC/CMC0.9 biocomposite promoted a slight lowering of MTX release rates, suggesting that the DS of CMC can be considered the key factor to modulate the BC properties.

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Section: Introductionmentioning

confidence: 99%

Effect of in situ modification of bacterial cellulose with carboxymethylcellulose on its nano/microstructure and methotrexate release properties

Fontes

Meneguin

Tercjak

et al. 2018

Carbohydrate Polymers

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“…OTiO 2 (w) exhibits four characteristic absorbance peaks, which are consistent with the reported functional groups on the surface of the as-received TiO 2 (w). The band at 3432 cm −1 can be assigned to the -OH stretching vibration [23]. The band observed at 937 cm −1 is characteristic of the C-P functional group.…”

Section: Resultsmentioning

confidence: 98%

Anti-Corrosive and Scale Inhibiting Polymer-Based Functional Coating with Internal and External Regulation of TiO2 Whiskers

Wang

et al. 2018

Coatings

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Abstract:A novel multi-functional carrier of mesoporous titanium dioxide whiskers (TiO 2 (w)) modified by ethylenediamine tetra (methylene phosphonic acid) (EDTMPA) and imidazoline was devised in epoxy coating to improve the anti-corrosion and scale inhibition properties of metal surface. Rigorous characterization using analytical techniques showed that a mesoporous structure was developed on the TiO 2 (w). EDTMPA and imidazoline were successfully grafted on the outer and inner surfaces of mesoporous TiO 2 (w) to synthesize iETiO 2 (w). The results demonstrated that the corrosion resistance of the final iETiO 2 (w) epoxy coating is 40 times higher than that of the conventional unmodified OTiO 2 (w) epoxy coating. The enhanced corrosion resistance of the iETiO 2 (w) functional coating is due to the chelation of the scaling cations by EDTMPA and electron sharing between imidazoline and Fe. Scale formation on the iETiO 2 (w) coating is 35 times lower than that on the unmodified OTiO 2 (w) epoxy coating. In addition, EDTMPA and imidazoline act synergistically in promoting the barrier property of mesoporous TiO 2 (w) in epoxy coating. It is believed that this novel, simple, and inexpensive route for fabricating functional surface protective coatings on various metallic materials will have a wide range of practical applications.

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“…The band at 1398 cm −1 observed in both spectra indicates the existence of hydrogen bonds that could be formed between the drug and the silica flakes ( Figure 5). It could also be related to the C-H bond stretching vibrations [38,39]. The band centered at 1450 cm −1 in both samples corresponds to the symmetric stretching mode of the COO-group, indicating the successful interaction of MTX and silica flakes [40].…”

Section: Silica Nanoflakes Characterizationmentioning

confidence: 85%

Folic Acid/Methotrexate Functionalized Mesoporous Silica Nanoflakes from Different Supports: Comparative Study

et al. 2020

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Herein, we present a facile synthesis route for the mesoporous silica nanoflakes on two types of templates and evaluate their potential as potential drug delivery systems. Silica materials are attractive due to their biocompatibility, low cytotoxicity, high surface area, and tunable pores. In addition, they can be multifunctionalized. These properties were used to create multifunctional drug delivery systems combining folic acid as a target molecule and methotrexate (MTX) as an anticancer drug. The silica nanoflakes were formed using graphene oxide and double-layered hydroxide as templates, respectively. After the removal of matrices, the silica flakes were functionalized by folic acid and loaded with methotrexate. The differences in drug release performance and structural stability were analyzed with respect to the detailed physicochemical characterization of the produced silica nanoflakes.

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Novel morphology change of Au-Methotrexate conjugates: From nanochains to discrete nanoparticles

Cited by 12 publications

References 55 publications

Effect of in situ modification of bacterial cellulose with carboxymethylcellulose on its nano/microstructure and methotrexate release properties

Effect of in situ modification of bacterial cellulose with carboxymethylcellulose on its nano/microstructure and methotrexate release properties

Anti-Corrosive and Scale Inhibiting Polymer-Based Functional Coating with Internal and External Regulation of TiO2 Whiskers

Folic Acid/Methotrexate Functionalized Mesoporous Silica Nanoflakes from Different Supports: Comparative Study

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