Novel Musculoskeletal and Orthopedic Applications of 18F-Sodium Fluoride PET

Raynor, William; Borja, Austin J; Hancin, Emily; Werner, Thomas; Alavi, Abass; Revheim, Mona-Elisabeth

doi:10.1016/j.cpet.2020.12.006

Cited by 17 publications

(12 citation statements)

References 190 publications

(178 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, correlations between 18 F-NaF uptake measured by SUV and age at the humeral shaft and lumbar spine have been reported to show opposite trends [ 49 ]. Overall, the validation of 18 F-NaF-PET for the treatment and diagnosis of osteoporosis with further studies will certainly enhance the way metabolic bone diseases are diagnosed and treated [ 7 , 50 ].…”

Section: 18 F-naf-pet In Metabolic Bone Disordersmentioning

confidence: 99%

“…18 F-NaF-PET/CT shows great promise for early detection and monitoring of heterotopic ossification, or external growth of bone outside of the normal skeletal system [ 50 , 96 ]. Recently, the potential of 18 F-NaF-PET/CT in diagnosing and predicting the onset of heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) has been gaining traction.…”

Section: 18 F-naf-pet In Osteogenic Bone Disordersmentioning

confidence: 99%

See 1 more Smart Citation

18F-Sodium Fluoride PET as a Diagnostic Modality for Metabolic, Autoimmune, and Osteogenic Bone Disorders: Cellular Mechanisms and Clinical Applications

Park

Raynor

Sun

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

In a healthy body, homeostatic actions of osteoclasts and osteoblasts maintain the integrity of the skeletal system. When cellular activities of osteoclasts and osteoblasts become abnormal, pathological bone conditions, such as osteoporosis, can occur. Traditional imaging modalities, such as radiographs, are insensitive to the early cellular changes that precede gross pathological findings, often leading to delayed disease diagnoses and suboptimal therapeutic strategies. 18F-sodium fluoride (18F-NaF)-positron emission tomography (PET) is an emerging imaging modality with the potential for early diagnosis and monitoring of bone diseases through the detection of subtle metabolic changes. Specifically, the dissociated 18F- is incorporated into hydroxyapatite, and its uptake reflects osteoblastic activity and bone perfusion, allowing for the quantification of bone turnover. While 18F-NaF-PET has traditionally been used to detect metastatic bone disease, recent literature corroborates the use of 18F-NaF-PET in benign osseous conditions as well. In this review, we discuss the cellular mechanisms of 18F-NaF-PET and examine recent findings on its clinical application in diverse metabolic, autoimmune, and osteogenic bone disorders.

show abstract

Section: 18 F-naf-pet In Metabolic Bone Disordersmentioning

confidence: 99%

Section: 18 F-naf-pet In Osteogenic Bone Disordersmentioning

confidence: 99%

18F-Sodium Fluoride PET as a Diagnostic Modality for Metabolic, Autoimmune, and Osteogenic Bone Disorders: Cellular Mechanisms and Clinical Applications

Park

Raynor

Sun

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Vascular Micro-calcification Unlike the nonspecific nature of FDG uptake, NaF localizes specifically to areas of ongoing calcification [46]. Therefore, NaF-PET images are not affected by physiologic myocardial uptake and therefore can detect early signs of coronary plaque micro-calcification in atherosclerosis.…”

Section: F-sodium Fluoride (Naf)mentioning

confidence: 99%

Emerging PET Tracers in Cardiac Molecular Imaging

Singh

Lau

et al. 2023

Cardiol Ther

Self Cite

View full text Add to dashboard Cite

18F-fluorodeoxyglucose (FDG) and 18 F-sodium fluoride (NaF) represent emerging PET tracers used to assess atherosclerosis-related inflammation and molecular calcification, respectively. By localizing to sites with high glucose utilization, FDG has been used to assess myocardial viability for decades, and its role in evaluating cardiac sarcoidosis has come to represent a major application. In addition to determining late-stage changes such as loss of perfusion or viability, by targeting mechanisms present in atherosclerosis, PET-based techniques have the ability to characterize atherogenesis in the early stages to guide intervention. Although it was once thought that FDG would be a reliable indicator of ongoing plaque formation, micro-calcification as portrayed by NaF-PET/CT appears to be a superior method of monitoring disease progression. PET imaging with NaF has the additional advantage of being able to determine abnormal uptake due to coronary artery disease, which is obscured by physiologic myocardial activity on FDG-PET/CT. In this review, we discuss the evolving roles of FDG, NaF, and other PET tracers in cardiac molecular imaging.Shashi Bhushan Singh and Sze Jia Ng contributed equally to this work.

show abstract

“…18 F-NaF binds minimally to protein and clears rapidly in the plasma, allowing for the precise and fast acquisition of image with low background uptake already within 45 to 60 min after administration (12,13). The role of 18 F-NaF-PET in diagnosis and clinical management of malignant bone diseases, benign osseous conditions, and atherosclerosis has been well-studied previously (14)(15)(16). While 18 F-NaF-PET has been employed to assess the sources of neck pain (8), its use for measuring age-related degenerative changes in the spine has not been fully explored.…”

Section: Introductionmentioning

confidence: 99%

Application of 18F-NaF-PET/CT in assessing age-related changes in the cervical spine

Park¹,

Raynor²,

Khurana³

et al. 2022

Quant Imaging Med Surg

Self Cite

View full text Add to dashboard Cite

Background: Cervical spondylosis is the degeneration of cervical spine often associated with aging and neck pain. As the degenerative changes are coupled with altered osteoblastic activity, imaging modalities sensitive to such molecular changes could be valuable for clinical assessment, disease prophylaxis, and monitoring early therapy response. In this study, we examined the role of 18 F-sodium fluoride-positron emission tomography/computed tomography ( 18 F-NaF-PET/CT) in detecting age-associated changes in the cervical spine of an adult population with broad age spectrum.Methods: In this retrospective cross-sectional study, we analyzed 18 F-NaF-PET/CT scans of 88 control volunteers (43 females, 45 males) with age ranging from 21 to 75 years (mean =44.6, standard deviation, 14.0) divided into younger (21-45 years) and older (46-75 years) age groups. A semi-automated global assessment technique was used to measure 18 F-NaF uptake in C2-C4 and C5-C7 vertebrae of the subjects. Furthermore, a CT-based scoring system was devised to measure the degree of structural degeneration.Results: There was a significant difference in 18 F-NaF uptake of the younger and older groups at the C5-C7 vertebrae for both females (younger: mean =4.13, 95% CI: 3.72-4.55; older: mean = 4.80, 95% CI: 4.40-5.20; P=0.005) and males (younger: mean =3.66, 95% CI: 3.24-4.09; older: mean =4.22, 95% CI: 3.80-4.64; P=0.009), but not at the C2-C4 vertebrae. Furthermore, there was a positive correlation between the degree of degeneration and 18 F-NaF uptake at both C2-C4 and C5-C7 spinal segments of both sexes.Conclusions: Aging is associated with increased 18 F-NaF uptake in the cervical spine, which may be associated with osteoblastic activity coupled with degeneration. Our study alludes to the potential role of 18 F-NaF-PET/CT in evaluating age-related degeneration and osteoarthritis of the spine.

show abstract

Novel Musculoskeletal and Orthopedic Applications of 18F-Sodium Fluoride PET

Cited by 17 publications

References 190 publications

18F-Sodium Fluoride PET as a Diagnostic Modality for Metabolic, Autoimmune, and Osteogenic Bone Disorders: Cellular Mechanisms and Clinical Applications

18F-Sodium Fluoride PET as a Diagnostic Modality for Metabolic, Autoimmune, and Osteogenic Bone Disorders: Cellular Mechanisms and Clinical Applications

Emerging PET Tracers in Cardiac Molecular Imaging

Application of 18F-NaF-PET/CT in assessing age-related changes in the cervical spine

Contact Info

Product

Resources

About