Novel nanofibrous dressings containing rhEGF and Aloe vera for wound healing applications

García-Orue, Itxaso; Gainza, Garazi; Gutierrez, Franciso Borja; Aguirre, José Antonio Cadiñanos; Évora, Carmen; Pedraz, José Luís; Hernández, Rosa María; Delgado, Araceli; Igartua, Manoli

doi:10.1016/j.ijpharm.2016.11.006

Cited by 166 publications

(108 citation statements)

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“…Hemostasis, inflammation, proliferation and remodeling are important steps of this process [6,13,14]. Previous studies indicated that because of hydroxyl moieties and 2-3 carbon double bond in molecule structure is responsible from Luteolin's several activities [18,19] including anti-inflammatory, antioxidant [6,18,19,20,22] and antimicrobial [5,19,22] which effected wound healing process positively [35].…”

Section: Histopathological Studymentioning

confidence: 99%

“…These steps can be characterized into four highly programmed phases such as hemostasis, inflammation, proliferation and remodeling [2,6,[12][13][14][15][16]. All phases of healing must occur in suitable sequence for successful healing as a natural phenomenon [6,12,13] but sometimes complex multifactorial process of wound healing can be delayed or failed by unwanted effects such as presence of free radicals [12,17] or microbial infections [5,12,16,17].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Wound Healing Properties of Luteolin Ointments on Excision and Incision Wound Models in Diabetic and Non-Diabetic Rats

Özay¹,

Güzel²,

Erdoğdu³

et al. 2018

Rec.Nat.Prod.

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Luteolin, which is structurally classified under the flavonoids, is naturally distributed abundant among medicinal plants, vegetables and fruits. The wound healing effects of Luteolin ointments were evaluated for incision and excision wound models on non-diabetic and Streptozotocin induced diabetic rats by using macroscopical, biomechanical, biochemical and histopathological methods. Two different concentrations (0.5 % and 1 % (w/w)) of the Luteolin ointment were prepared with the mixture of glycol stearate:propylene glycol:liquid paraffin (3:6:1) and 0.5 g of the ointments were applied topically on wounds once daily for 7 and 14 days. During the experiments, wounds were visually observed, photographically documented and wound areas were measured. After 7 and 14 days treatment, animals were sacrificed under anesthesia and hydroxyproline measurement and biomechanical analysis were performed. Histopathology of the wound area was evaluated considering features of re-epithelialization, thickness of the granulation tissue, angiogenesis, presence of inflammation, number of mast cells. Outcomes of this study revealed that Luteolin ointments improved wound healing process of skin tissue both in non-diabetic and diabetic wounds. The best wound healing activity was observed in incision and excision wounds (97.6 %, 96.1 %, respectively) treated with 0.5 % (w/w) Luteolin ointment on day 14 according to macroscopic results.

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Section: Histopathological Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the Wound Healing Properties of Luteolin Ointments on Excision and Incision Wound Models in Diabetic and Non-Diabetic Rats

Özay¹,

Güzel²,

Erdoğdu³

et al. 2018

Rec.Nat.Prod.

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show abstract

“…16 Regranex gel has defined our understanding of growth factor mediated gels for wound healing, and the use of PDGF has been common for many years. [20][21][22][23][24] Other commonly used growth factors include the epidermal growth factor (EGF), [25][26][27][28][29][30][31] fibroblast growth factor (FGF), 21,26,27,32,33 and vascular endothelial growth factor (VEGF). [34][35][36] Table I has a summary of growth factor modified materials and their corresponding strategies for growth factor encapsulation and delivery.…”

Section: Growth Factor Delivery and Microenvironment Recapitulationmentioning

confidence: 99%

Review: Multimodal bioactive material approaches for wound healing

2018

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Wound healing is a highly complex process of tissue repair that relies on the synergistic effect of a number of different cells, cytokines, enzymes, and growth factors. A deregulation in this process can lead to the formation of a non-healing chronic ulcer. Current treatment options, such as collagen wound dressings, are unable to meet the demand set by the wound environment. Therefore, a multifaceted bioactive dressing is needed to elicit a targeted affect. Wound healing strategies seek to develop a targeted effect through the delivery of a bioactive molecule to the wound by a hydrogel or a polymeric scaffold. This review examines current biomaterial and small molecule-based approaches that seek to develop a bioactive material for targeted wound therapy and accepted wound healing models for testing material efficacy.

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“…Garcia-Orue et al (72) studied the effects of 'nanofibrous' dressings containing recombinant human epidermal growth factor (rhEGF) and Aloe vera extract on wound healing. They demonstrated in vitro that the membranes improved fibroblast proliferation at the wound site.…”

Section: Woundsmentioning

confidence: 99%