Novel nanostructured resin infiltrant containing calcium phosphate nanoparticles to prevent enamel white spot lesions

Dai, Zixiang; Xie, Xianju; Zhang, Ning; Li, Song; Yang, Kai; Zhu, Minjia; Weir, Michael D.; Xu, Hockin H.K.; Zhang, Ke; Zhao, Zeqing; Bai, Yuxing

doi:10.1016/j.jmbbm.2021.104990

Cited by 17 publications

(25 citation statements)

References 41 publications

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“…It is doubtful whether the hardness could recover after resin infiltration. Some studies showed that the hardness of infiltrated enamel was less than sound enamel, while others showed increased hardness value ( Maupomé et al., 1998 ; Huang et al., 2010 ; Paris et al., 2013 ; Dai et al., 2022 ). For instance, in Dai’s in vitro study, the enamel treated with ICON showed lower hardness (1.7 GPa) compared to sound enamel and experimental resin infiltrant containing TEGDMA and BisGMA ( Dai et al., 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies showed that the hardness of infiltrated enamel was less than sound enamel, while others showed increased hardness value ( Maupomé et al., 1998 ; Huang et al., 2010 ; Paris et al., 2013 ; Dai et al., 2022 ). For instance, in Dai’s in vitro study, the enamel treated with ICON showed lower hardness (1.7 GPa) compared to sound enamel and experimental resin infiltrant containing TEGDMA and BisGMA ( Dai et al., 2022 ). The reason may be that the ICON infiltrant possessed a polymer network mainly consisting of TEGDMA, which composition is likely to lead to lower hardness properties for the ICON infiltrant ( Chen et al., 2019 ; Dai et al., 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…For instance, in Dai’s in vitro study, the enamel treated with ICON showed lower hardness (1.7 GPa) compared to sound enamel and experimental resin infiltrant containing TEGDMA and BisGMA ( Dai et al., 2022 ). The reason may be that the ICON infiltrant possessed a polymer network mainly consisting of TEGDMA, which composition is likely to lead to lower hardness properties for the ICON infiltrant ( Chen et al., 2019 ; Dai et al., 2022 ). Furthermore, BisGMA and TEGDMA based infiltrants may reduce polymerization shrinkage due to higher molecular weight ( Paris et al., 2013 ).…”

Section: Discussionmentioning

confidence: 99%

“…However, resin infiltant can only seal off about 30-60% of the enamel pore volume ( Kielbassa et al., 2009 ; Yim et al., 2014 ). Furthermore, after the attack of acid produced by cariogenic microorganisms, the hardness of enamel decreased significantly ( Dai et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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Novel dental resin infiltrant containing smart monomer dodecylmethylaminoethyl methacrylate

Huang

Liang

Zhou

et al. 2022

Front. Cell. Infect. Microbiol.

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ObjectivesWhite spot lesions (WSLs) are prevalent and often lead to aesthetic problems and progressive caries. The objectives of this study were to: (1) develop a novel resin infiltrant containing smart monomer dodecylmethylaminoethyl methacrylate (DMAEM) to inhibit WSLs, and (2) investigate the effects of DMAEM incorporation on cytotoxicity, mechanical properties, biofilm-inhibition and protection of enamel hardness for the first time.MethodsDMAEM was synthesized using 1-bromododecane, 2-methylamino ethanol and methylmethacrylate. DMAEM with mass fractions of 0%, 1.25%, 2.5% and 5% were incorporated into a resin infiltant containing BisGMA and TEGDMA. Cytotoxicity, mechanical properties and antibacterial effects were tested. After resin infiltration, bovine enamel was demineralized with saliva biofilm acids, and enamel hardness was measured.ResultDMAEM infiltration did not increase the cytotoxicity or compromise the physical properties when DMAEM mass fraction was below 5% (p > 0.05). Biofilm metabolic activity was reduced by 90%, and biofilm lactic acid production was reduced by 92%, via DMAEM (p < 0.05). Mutans streptococci biofilm CFU was reduced by 3 logs (p < 0.05). When demineralized in acid and then under biofilms, the infiltrant + 5% DMAEM group produced an enamel hardness (mean ± sd; n = 6) of 2.90 ± 0.06 GPa, much higher than 0.85 ± 0.12 GPa of the infiltrant + 0% DMAEM group (p < 0.05).SignificanceA novel resin infiltrant with excellent mechanical properties, biocompability, strong antibacterial activity and anti-demineralization effect was developed using DMAEM for the first time. The DMAEM resin infiltrant is promising for inhibiting WSLs, arresting early caries, and protecting enamel hardness.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Novel dental resin infiltrant containing smart monomer dodecylmethylaminoethyl methacrylate

Huang

Liang

Zhou

et al. 2022

Front. Cell. Infect. Microbiol.

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“…[16] Icon resin infiltration incorporated with nanoparticles of amorphous calcium phosphate shows promising effect of inhibiting enamel White spot lesions, shield the enamel and increase its hardness. [17]…”

Section: Split Mouth Randomized Controlled Trialmentioning

confidence: 99%

Systematic Review on the Efficacy of Icon Resin Infiltration on White Spot Lesions

Gousalya¹,

Prabu²,

M³

et al. 2022

ijocd

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Background: Resin infiltration is a new therapeutic technique for WSLs (white spot lesions) that may bridge nonoperative and operative treatment options. It's a minimally invasive procedure for filling, reinforcing, and stabilizing demineralized enamel without drilling or compromising good tooth structure. It has also been found to slow the progression of caries in lesions that are too advanced to be treated with fluoride. The current investigation of this systematic review is to evaluate the efficacy of ICON® resin infiltration on WSLs. This literature review was conducted and reported according to the PRISMA (Preferred Reporting Items for Systematic Review and Metaanalysis) statement. Seven databases (PubMed, Cochrane Library, CINAHL, OVID MEDLINE, EMBASE, Grey Literature, Wiley Online Library) were used. The MeSH terms used were 'Icon resin infiltration, ' white spot lesions, and 'clinical trials. PICOS analysis of Population-Participants with white spot lesions; Intervention-Icon Resin Infiltration; Comparison-Comparing with other different therapies; Outcome-Regression or disappearance of lesions; Study design-Randomized controlled trials. Five cross-sectional studies were included in this systematic review for the quality assessment of the efficacy of Icon resin infiltration on white spot lesions. All five studies reported a statistically significant difference between the Icon resin infiltration, lesion loss ratio, and color change. This systematic review concludes that the Icon resin infiltration on white spot lesion is effective during the initial period, i.e. first three months. Over time there is a color change in its masking. However, it is effective in reducing the lesion loss ratio.

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Design and Development of Infiltration Resins: From Base Monomer Structure to Resin Properties

Yang,

Zhao,

Liu

et al. 2024

Chemistry An Asian Journal

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The resin infiltration technology concept is one of the most widely used minimally invasive restorative techniques in restorative dentistry with the most outstanding therapeutic effect, and it is also one of the key research directions in restorative dentistry. "Infiltration resin" is the specialty restorative material for the technology, which is the key factor to success. The specialized restorative material is commonly known as "infiltrant/infiltration resins" "resins infiltrant" "infiltrant" or "resins," which will be consistently referred to as "infiltration resins" throughout the article.‐The paper aims to provide a comprehensive overview of infiltration resins by introducing the development of their therapeutic mechanisms, basic components, current challenges, and future trends, Based on existing literature, we analyze and compare how changes in the base monomer's structure and ratio affect the effectiveness of infiltration resins, from the material's structure‐effective relationship. After compiling the information, the existing solution strategies have been listed to offer substantial support and guidance for future research endeavors.

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Novel nanostructured resin infiltrant containing calcium phosphate nanoparticles to prevent enamel white spot lesions

Cited by 17 publications

References 41 publications

Novel dental resin infiltrant containing smart monomer dodecylmethylaminoethyl methacrylate

Novel dental resin infiltrant containing smart monomer dodecylmethylaminoethyl methacrylate

Systematic Review on the Efficacy of Icon Resin Infiltration on White Spot Lesions

Design and Development of Infiltration Resins: From Base Monomer Structure to Resin Properties

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