Novel nicotinic action of the sulfoximine insecticide sulfoxaflor

Watson, Gerald B.; Loso, Michael R.; Babcock, Jon; Hasler, James M.; Letherer, Theodore J; Young, Cathy D.; Zhu, Yujie; Casida, John E.; Sparks, Thomas C.

doi:10.1016/j.ibmb.2011.01.009

Cited by 158 publications

(124 citation statements)

References 22 publications

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“…12) Sulfoxaflor, the newest neonicotinoid discovered by Dow AgroSciences, acts on nAChRs as an agonist. 13,14) It exhibits high potency and lacks insecticidal cross-resistance; thus it could be used as an alternative to control sap-feeding insect pests. 15) It is expected to be introduced in 2013 in China as long as the registrations are granted.…”

Section: Research and Development Of Novel Neonicotinoid Moleculesmentioning

confidence: 99%

Overall status of neonicotinoid insecticides in China: Production, application and innovation

et al. 2013

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Section: Research and Development Of Novel Neonicotinoid Moleculesmentioning

confidence: 99%

Overall status of neonicotinoid insecticides in China: Production, application and innovation

et al. 2013

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“…There is increasing evidence that pesticide use at lethal and sublethal concentrations is contributing towards pollinator declines and affecting behavioural responses of non-target organisms [1][2][3][4]. Pesticides such as the neonicotinoids are widely used and are effective in the control of many insect pests [5,6]. These chemicals interact with acetylcholine receptors, and directly affect the central and peripheral nervous system of insects [7,8].…”

Section: Introductionmentioning

confidence: 99%

A neurotoxic pesticide changes the outcome of aggressive interactions between native and invasive ants

et al. 2013

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Neurotoxic pesticides, such as neonicotinoids, negatively affect the cognitive capacity and fitness of non-target species, and could also modify interspecific interactions. We tested whether sublethal contamination with neonicotinoid could affect foraging, colony fitness and the outcome of behavioural interactions between a native (Monomorium antarcticum) and an invasive ant species (Linepithema humile). The foraging behaviour of both ants was not affected by neonicotinoid exposure. Colonies of the invasive species exposed to the neonicotinoid produced significantly fewer brood. In interspecific confrontations, individuals of the native species exposed to the neonicotinoid lowered their aggression towards the invasive species, although their survival probability was not affected. Exposed individuals of the invasive species interacting with non-exposed native ants displayed increased aggression and had their survival probability reduced. Nonexposed individuals of the invasive species were less aggressive but more likely to survive when interacting with exposed native ants. These results suggest that non-target exposure of invaders to neonicotinoids could either increase or decrease the probability of survival according to the exposure status of the native species. Given that, in any community, different species have different food preferences, and thus different exposure to pesticides, non-target exposure could potentially change the dynamics of communities and influence invasion success.

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“…102,108) Such structural differences have been proposed to differentiate SFX from the other neonicotinoids in the manner with which it interacts at the nAChRs. 91,118) 35 pM). Therefore, it was suggested that SFX interacts at the high affinity (sub-nM K d ) IMI binding site but the affinity of SFX at this site in aphids is considerably higher.…”

Section: Sulfoximinesmentioning

confidence: 99%

“…The fact that SFX only interacts at the high affinity IMI binding site and has much reduced ability to interact at the second lower affinity IMI binding site, explains the relative weakness of SFX to displace [ 3 H]-IMI under standard assay conditions. 118,119) 54) This novel systemic insecticide for sucking pest control was identified by stepwise chemical evolution of the enaminocarbonyl pharmacophore inspired by existing nAChR ligands [120][121][122] and also recognized as a recurrent motif of natural products such as stemofoline, another botanical insecticide. 123,124) Flupyradifurone modulates insect nAChRs at the orthosteric binding site potently displacing [ 3 H]-IMI bound to M. domestica crude membranes with low nM affinity (IC 50 =2.38±1.93 nM).…”

Section: Sulfoximinesmentioning

confidence: 99%

The invertebrate pharmacology of insecticides acting at nicotinic acetylcholine receptors

Crossthwaite

Bigot

Camblin

et al. 2017

Journal of Pesticide Science

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The nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel composed of 5 protein subunits arranged around a central cation selective pore. Several classes of natural and synthetic insecticides mediate their effect through interacting at nAChRs. This review examines the basic pharmacology of the neonicotinoids and related chemistry, with an emphasis on sapfeeding insects from the order Hemiptera, the principle pest target for such insecticides. Although the receptor subunit stoichiometry for endogenous invertebrate nAChRs is unknown, there is clear evidence for the existence of distinct neonicotinoid binding sites in native insect preparations, which reflects the predicted wide repertoire of nAChRs and differing pharmacology within this insecticide class. The spinosyns are principally used to control chewing pests such as Lepidoptera, whilst nereistoxin analogues are used on pests of rice and vegetables through contact and systemic action, the pharmacology of both these insecticides is unique and different to that of the neonicotinoids.

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Novel nicotinic action of the sulfoximine insecticide sulfoxaflor

Cited by 158 publications

References 22 publications

Overall status of neonicotinoid insecticides in China: Production, application and innovation

Overall status of neonicotinoid insecticides in China: Production, application and innovation

A neurotoxic pesticide changes the outcome of aggressive interactions between native and invasive ants

The invertebrate pharmacology of insecticides acting at nicotinic acetylcholine receptors

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