Novel nuclear matrix protein HET binds to and influences activity of the HSP27 promoter in human breast cancer cells

Oesterreich, Steffi; Lee, Adrian V.; Sullivan, Toby; Samuel, Shanti K.; Davie, James R.; Fuqua, Suzanne A.W.

doi:10.1002/(sici)1097-4644(19971101)67:2<275::aid-jcb13>3.3.co;2-5

Cited by 22 publications

(40 citation statements)

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“…Furthermore, in addition to the findings of our group, the specific VDRE and ERE regulatory control by ‘non-receptor’ response element binding proteins has been endorsed by the involvement of other non-related components such as the ubiquitous transcription regulator YY1 (i.e. Ying Yang 1, a GLI-Kruppel class of zinc finger protein) (29) and the scaffold attachment factor B (30), respectively. These findings provide additional evidence for the complex regulation of steroid hormones and their receptors targeting VDREs and EREs in different cellular systems.…”

Section: Hormone Response Element (Hre) Interactorsmentioning

confidence: 65%

“…Also, G-protein mutations (e.g. GNAS1) cause Albright's hereditary osteodystrophy (30), which leads to intramembranous ossifications progressively developed from the dermis.…”

Section: Hormone Resistancementioning

confidence: 99%

“…In a similar fashion, heat shock protein 27 (hsp27) enhances both growth and drug resistance in breast cancer cells, and is a bad prognostic factor in certain subsets of breast cancer patients. The hsp27 promoter contains an imperfect estrogen response element (ERE) that is separated by a 13-bp spacer that contains a TATA box to which the scaffold attachment factor B (SAF-B) binds (30). Scaffold attachment factors are a subset of nuclear matrix proteins (NMP) that interact with matrix attachment regions.…”

Section: Hormone Response Element (Hre) Interactorsmentioning

confidence: 99%

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Hormone response element binding proteins: Novel regulators of vitamin D and estrogen signaling

Lisse¹,

Hewison²,

Adams³

2011

Steroids

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Insights from vitamin D-resistant New World primates and their human homologues as models of natural and pathological insensitivity to sterol/steroid action have uncovered a family of novel intracellular vitamin D and estrogen regulatory proteins involved in hormone action. The proteins, known as "vitamin D or estrogen response element-binding proteins", behave as potent cis-acting, transdominant regulators to inhibit steroid receptor binding to DNA response elements and is responsible for vitamin D and estrogen resistances. This set of interactors belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family of previously known pre-mRNAinteracting proteins. This review provides new insights into the mechanism by which these novel regulators of signaling and metabolism can act to regulate responses to vitamin D and estrogen. In addition the review also describes other molecules that are known to influence nuclear receptor signaling through interaction with hormone response elements.

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Section: Hormone Response Element (Hre) Interactorsmentioning

confidence: 65%

“…Also, G-protein mutations (e.g. GNAS1) cause Albright's hereditary osteodystrophy (30), which leads to intramembranous ossifications progressively developed from the dermis.…”

Section: Hormone Resistancementioning

confidence: 99%

Section: Hormone Response Element (Hre) Interactorsmentioning

confidence: 99%

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Hormone response element binding proteins: Novel regulators of vitamin D and estrogen signaling

Lisse¹,

Hewison²,

Adams³

2011

Steroids

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“…SAF-B is a nuclear matrix-associated factor inactivated by active caspase-3 and involved in the regulation of HSP27. 19,20 Decreased level of HSP27 was observed in cotreated MA-11 cells (Fig. 3B, left panel).…”

Section: Its In Combination With Tpmp-i-2 Results In Inactivation Of Parpmentioning

confidence: 87%

Triphenylmethyl Derivatives Enhances the Anticancer Effect of Immunotoxins

Risberg

Guldvik

Palchaudhuri

et al. 2011

Journal of Immunotherapy

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The combined use of several drugs targeting different cellular functions is one approach to achieve tumor control in cancer. We studied the effects of Pseudomonas exotoxin A (PE)-based immunotoxins (ITs), the 9.2.27PE and the 425.3PE, together with 2 different triphenylmethyl derivatives, triphenylmethyl phosphonates and phosphonochloridates (TPMP)-I-2 and 4BI. Combining the triphenylmethyl derivatives with ITs enhanced the cytotoxic effect of the ITs, with TPMP-I-2 in combination with the 425.3PE (targeting the epidermal growth factor receptor) being the most promising combination. The cytotoxicity involving signs of apoptosis was observed in cancer cells from different origins in vitro. It is interesting to note that treatment with IT, TPMP-I-2, or 4BI alone or in combination resulted in strongly decreased protein levels of stearoyl-CoA desaturase. Stearoyl-CoA desaturase is the rate-limiting enzyme for converting saturated fatty acids into monounsaturated fatty acids needed for membrane genesis. Furthermore, the combination of 425.3PE and TPMP-I-2 prolonged the survival time of nude rats in a simulated micrometastatic cervical cancer model. In addition, we demonstrate that a combination of the 425.3PE and 4BI was more effective in reducing tumor growth in a breast cancer model in nude mice compared with either agent alone.

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“…The locus control regions bind to multiple transcription factors that cooperate synergistically to activate gene transcription. On the other hand, the MARs may act as specific landmarks that anchor DNA to the nuclear scaffold (28). It has been shown that a MAR, present on the ovine ␤-lactoglobulin gene, modulates basal transgene expression in transgenic mice (29).…”

Section: Tissue- Region- and Cell-specific Expression Of The 53mepmentioning

confidence: 99%

The 5′-Flanking Region of the Murine Epididymal Protein of 17 Kilodaltons Gene Targets Transgene Expression in the Epididymis

Suzuki¹,

Araki²,

Zhu³

et al. 2003

Endocrinology

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A murine epididymal retinoic-acid-binding protein (mE-RABP) is specifically expressed in the mid/distal caput epididymidis and is androgen regulated. The murine epididymal protein of 17 kDa (mEP17) gene, a novel gene homologous to mE-RABP, is located within 5 kb of the 5'-flanking region of the mE-RABP gene. In contrast, expression of the mEP17 gene is restricted to the initial segment and regulated by factor(s) contained in testicular fluid. To identify cis-DNA regulatory element(s) involved in the tissue- and region-specific expression of the mEP17 gene in transgenic mice, we have studied the expression of a transgene containing 5.3 kb of the 5'-flanking region of the mEP17 gene (5.3mEP17) linked to chloramphenicol acetyltransferase (CAT) reporter gene. Significant caput epididymidis-specific CAT activity was detected in transgenic mouse lines; and CAT gene expression is restricted to the initial segment, as is the expression of the endogenous mEP17 gene. Ontogenic expression and testicular factor dependency also mimic that of endogenous mEP17 gene. These results suggest that the 5.3mEP17 fragment contains all the information required for spatial and temporal expression in the mouse epididymis. The 5.3mEP17 fragment will be useful to express a foreign gene of interest in the epididymis in an initial segment-specific manner.

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Novel nuclear matrix protein HET binds to and influences activity of the HSP27 promoter in human breast cancer cells

Cited by 22 publications

References 0 publications

Hormone response element binding proteins: Novel regulators of vitamin D and estrogen signaling

Hormone response element binding proteins: Novel regulators of vitamin D and estrogen signaling

Triphenylmethyl Derivatives Enhances the Anticancer Effect of Immunotoxins

The 5′-Flanking Region of the Murine Epididymal Protein of 17 Kilodaltons Gene Targets Transgene Expression in the Epididymis

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