Novel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2

Wang, Yiting; Long, Xin-Yan; Ding, Xiao; Fan, Shi-Rui; Cai, Jiangping; Yang, Bo; Zhang, Xinfang; Luo, Rong-Hua; Yang, Lian; Ruan, Ting; Ren, Juan; Jing, Chuanyong; Zheng, Yong‐Tang; Hao, Xiao‐Jiang; Chen, Duo-Zhi

doi:10.1016/j.ejmech.2021.113966

Cited by 23 publications

(10 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The drug Naproxen binds and interacts with the key residues Thr50, Ala51, Tyr112, and Arg150 [ 119 ]. Also, in vitro assays indicated that the phenanthridine derivatives could bind to the N-NTD cavity to inhibit the SARS-CoV-2 replication [ 121 ]. We have found that fortunellin occupies a similar location and interacts with the residues Thr50, Ala51, Arg89, Ala91, Thr92, Arg93, Tyr110, Tyr112, Pro118, Arg150, Asn151, and Pro152 ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Computational exploration of the dual role of the phytochemical fortunellin: Antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the host

Agrawal

Pathak

Mishra

et al. 2022

Computers in Biology and Medicine

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Computational exploration of the dual role of the phytochemical fortunellin: Antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the host

Agrawal

Pathak

Mishra

et al. 2022

Computers in Biology and Medicine

View full text Add to dashboard Cite

“…Most of these compounds can tightly interact with the SARS-CoV-2 N protein and inhibit the replication of SARS-CoV-2. Among them, compounds 12 ( 10 ) and 16 ( 11 ) displayed the most potent antiviral activities, with a same K D value of 7.82 μM and EC 50 values of 3.69 and 2.18 μM, respectively (Figure ); therefore, these compounds can be further applied in G4-based antiviral studies.…”

Section: Viral G4-binding Proteinsmentioning

confidence: 95%

Targeting the RNA G-Quadruplex and Protein Interactome for Antiviral Therapy

et al. 2022

View full text Add to dashboard Cite

In recent years, G-quadruplexes (G4s), types of noncanonical four-stranded nucleic acid structures, have been identified in many viruses that threaten human health, such as HIV and Epstein–Barr virus. In this context, G4 ligands were designed to target the G4 structures, among which some have shown promising antiviral effects. In this Perspective, we first summarize the diversified roles of RNA G4s in different viruses. Next, we introduce small-molecule ligands developed as G4 modulators and highlight their applications in antiviral studies. In addition to G4s, we comprehensively review the medical intervention of G4-interacting proteins from both the virus (N protein, viral-encoded helicases, severe acute respiratory syndrome-unique domain, and Epstein–Barr nuclear antigen 1) and the host (heterogeneous nuclear ribonucleoproteins, RNA helicases, zinc-finger cellular nucelic acid-binding protein, and nucleolin) by inhibitors as an alternative way to disturb the normal functions of G4s. Finally, we discuss the challenges and opportunities in G4-based antiviral therapy.

show abstract

“…SPR sensors were used to characterize the binding affinity between the component of traditional Chinese medicine, epigallocatechin-3-gallate (EGCG), and the protease of SARS-CoV-2, 3CLpro, by Du et al [ 119 ]. Wang et al [ 120 ] designed and synthesized phenanthridine derivatives that specifically bind to the N protein. SPR sensors were used to screen these derivatives, and the optimal binding affinity could reach 2.18 µM.…”

Section: Spr-based Biosensorsmentioning

confidence: 99%

Recent Advances of Representative Optical Biosensors for Rapid and Sensitive Diagnostics of SARS-CoV-2

Lin

et al. 2022

Biosensors

View full text Add to dashboard Cite

The outbreak of Corona Virus Disease 2019 (COVID-19) has again emphasized the significance of developing rapid and highly sensitive testing tools for quickly identifying infected patients. Although the current reverse transcription polymerase chain reaction (RT-PCR) diagnostic techniques can satisfy the required sensitivity and specificity, the inherent disadvantages with time-consuming, sophisticated equipment and professional operators limit its application scopes. Compared with traditional detection techniques, optical biosensors based on nanomaterials/nanostructures have received much interest in the detection of SARS-CoV-2 due to the high sensitivity, high accuracy, and fast response. In this review, the research progress on optical biosensors in SARS-CoV-2 diagnosis, including fluorescence biosensors, colorimetric biosensors, Surface Enhancement Raman Scattering (SERS) biosensors, and Surface Plasmon Resonance (SPR) biosensors, was comprehensively summarized. Further, promising strategies to improve optical biosensors are also explained. Optical biosensors can not only realize the rapid detection of SARS-CoV-2 but also be applied to judge the infectiousness of the virus and guide the choice of SARS-CoV-2 vaccines, showing enormous potential to become point-of-care detection tools for the timely control of the pandemic.

show abstract

Novel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2

Cited by 23 publications

References 22 publications

Computational exploration of the dual role of the phytochemical fortunellin: Antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the host

Computational exploration of the dual role of the phytochemical fortunellin: Antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the host

Targeting the RNA G-Quadruplex and Protein Interactome for Antiviral Therapy

Recent Advances of Representative Optical Biosensors for Rapid and Sensitive Diagnostics of SARS-CoV-2

Contact Info

Product

Resources

About