Present study involves the synthesis, characterization, antimalarial and anticancer activities of some
novel substituted amino analogues of 1,4-naphthoquinone. The chloro group present in the key starting
materials like 2,3-dichloro-1,4-naphthoquinone (1) and 2-chloro-3-[trans-4-(4-chlorophenyl)-
cyclohexyl]-1,4-naphthoquinone (2) was replaced by substituted amines. These analogues were isolated,
purified and screened for antimalarial and anticancer activities. A few of the novel compounds were
found to possess substantial biological activity and are reasonably potent.