Novel observations in choroidal osteoma by multispectral imaging: a pilot case series

Ma, Feiyan; Li, Tianhang; Kozák, Igor; Shang, Qingli; Ma, Jingxue

doi:10.1007/s10792-020-01528-9

Cited by 12 publications

(14 citation statements)

References 38 publications

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“…The mean age of our patients was 36.3 years old, and 61% of patients were women. Tumors were unilateral in the majority of patients (92.7%), as described previously [3,4,6,7]. The etiology of choroidal osteomas is unknown.…”

Section: Discussionsupporting

confidence: 52%

“…Visual prognosis of choroidal osteoma cases is generally poor, as more than 50% of patients will develop impaired vision after 10 years [3,4]. In the present study, 11.4% of eyes at the initial presentation and 29.5% at final examination [4,5,7]. In the univariate analysis, we found that the presence of CNV, RPE change, PR atrophy, foveal invasion of the tumor, and ORT were associated with the risk of developing visual impairment.…”

Section: Discussionsupporting

confidence: 45%

“…Choroidal osteomas was first described in 1978 by Gass et al [1] and has only rarely been reported: only 61 patients were reported to have been treated at a major ocular oncology center over a 26-year period [3]. The tumors are typically found in otherwise healthy women in the second or third decades of life [3,4,6,7]. As little is known about these tumors, we here reported on our experience of the complications, treatments, and visual prognosis of this condition at a single center over the course of 15 years.…”

Section: Discussionmentioning

confidence: 99%

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Complications, treatments, and visual prognosis of choroidal osteomas

Seong

Kim

Choi

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Purpose This study aims to report complications, treatments, and visual prognosis of choroidal osteoma. Methods We retrospectively reviewed electronic medical records and multimodal images of 41 patients with choroidal osteoma. Results Visually significant complications included choroidal neovascularization (CNV) in 21 (47.7%) eyes and subretinal fluid (SRF) without CNV in 14 (31.8%) eyes. The most common treatment was intravitreal anti-vascular endothelial growth factor (VEGF) injection: 13 (61.9%) eyes with CNV received an average of 6.3 injections, and 6 (42.9%) eyes with SRF but without CNV received 1.8 injections. As the first-line treatment, intravitreal anti-VEGF injection induced complete or partial remission in 93.4% of eyes with CNV and 57.1% of eyes with SRF. The probability of legally low vision estimated at 3 and at 5 years was 29.1% and 34.2%, respectively. The presence of CNV and outer retinal tubulation (ORT) was independent risk factors for vision loss (adjusted odds ratio, 8.08 and 6.94, respectively). Conclusions The development of CNV and ORT was strong risk factors for visual impairment. Due to the frequent recurrence of complications and poor visual prognosis, regular check-ups and appropriate treatment choices are warranted.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 99%

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Complications, treatments, and visual prognosis of choroidal osteomas

Seong

Kim

Choi

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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“…18,21 Short wavelength slabs (550, 600, and 620 nm) were used to evaluate neurosensory retinal abnormalities, whereas middle wavelength slabs (680 and 780 nm) were used to evaluate RPE-Bruch membranechoriocapillaris complex, and infrared wavelength slabs (810 and 850 nm) are more penetrative, and choroidal changes are more readily visible in this section. 24 Multispectral imaging features on polypoidal choroidal vasculopathy lesions. The features of polypoidal lesions and branching vascular network on MSI were analyzed based on a previous report, and our current observations are as follows: 1) polypoidal lesions on MSI presented as nodular or nebulous hyperreflectance with ring-like hyperreflection border with dark hyporeflectance center usually observed from 680 nm and above.…”

Section: Image Reading and Multispectral Imaging Diagnostic Character...mentioning

confidence: 99%

Sensitivity and Specificity of Multispectral Imaging for Polypoidal Choroidal Vasculopathy

Ma¹,

Yuan

Kozák

et al. 2021

Retina

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Purpose: To evaluate the sensitivity and specificity of multispectral imaging (MSI), a noninvasive imaging technique composed of a series of monochromatic scanning light, for polypoidal choroidal vasculopathy (PCV).Methods: This was a prospective observational study. Polypoidal lesions on MSI are defined by oval or lobular hyperreflective oval lesion with dark hyporeflective center. Branching vascular networks on MSI is featured by hyperreflective interlacing signal. Detection sensitivity and specificity of polypoidal lesions was compared with indocyanine green angiography, whereas sensitivity and specificity of branching vascular networks, subretinal fluid, and pigment epithelium detachment were compared with optical coherence tomography.Results: Among 67 eyes, 38 eyes (56.7%) were diagnosed with PCV, 7 eyes (10.4%) with neovascular age-related macular degeneration, 13 eyes (19.4%) with central serous chorioretinopathy, 6 eyes (9.0%) with pathological myopia, and 3 eyes (4.5%) with idiopathic choroidal neovascularization. Compared with indocyanine green angiography, the sensitivity and specificity for diagnosing PCV by MSI alone was 84.21% and 93.10%, respectively, and the positive predictive value and the negative predictive value for PCV by MSI was 94.12% and 81.82%, respectively. The sensitivity and specificity for detecting polypoidal lesions were 84.21% and 93.10% compared with indocyanine green angiography. Compared with optical coherence tomography, the sensitivity and specificity for detecting branching vascular networks were 95.83% and 88.37%, for the subretinal fluid were 76.92% and 86.67%, and for the pigment epithelium detachment were 91.11% and 90.91%, respectively.Conclusion: Multispectral imaging allowed noninvasive visualization of polypoidal lesions and branching vascular networks and may serve as a new diagnostic option for PCV.

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“…Other researches have also described retinal pigmented epithelium (RPE) and external retinal layer abnormalities in the deossified portion of the tumor [ 3 ], subretinal fluid [ 4 ], macular neovascularization (MNV) [ 4 ], irregular tumor surface [ 3 ], focal choroidal excavation [ 4 ] and osteoma protrusion into the vitreous [ 4 ] as OCT findings in choroidal osteoma.…”

mentioning

confidence: 99%