Novel Ocimumoside A and B as anti-stress agents: Modulation of brain monoamines and antioxidant systems in chronic unpredictable stress model in rats

Ahmad, Ausaf; Rasheed, Naila; Gupta, Prasoon; Singh, Seema; Siripurapu, Kiran B.; Ashraf, Ghulam Md; Rajnish, Kumar; Chand, Kailash; Maurya, Rakesh; Banu, Naheed; Al-Sheeha, Muneera; Palit, Gautam

doi:10.1016/j.phymed.2012.02.012

Cited by 36 publications

(21 citation statements)

References 34 publications

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“…It is considered as the most valuable and stable model of depression in animals [7]. The results of the present study showed that rats subjected to a 7-week period of CUS exhibited depressive-like behaviour with reduced weight, low motor activity, increased defecation and reduced consumption of sucrose compared with the control group, in consistency with many previous reports [2,22,23]. The sucrose preference test is an indicator of anhedonia-like behavioural change [27].…”

Section: Discussionsupporting

confidence: 91%

“…The CUS procedure was performed as described by Ausaf et al [2], but with slight modifications. Rats in stressed groups were exposed to varying stressors once daily for 7 weeks: 24 h of food deprivation, 24 h of water deprivation, 24 h of cage tilt (45 • ), 1 min of tail pinch (1 cm from the end of the tail), 2 h of restraint stress, 4 min of exposure to 45 or 4 • C and overnight illumination.…”

Section: Methodsmentioning

confidence: 99%

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Antidepressant-like effects of paeoniflorin on the behavioural, biochemical, and neurochemical patterns of rats exposed to chronic unpredictable stress

Qiu

Zhang

Mao

et al. 2013

Neuroscience Letters

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Antidepressant-like effects of paeoniflorin on the behavioural, biochemical, and neurochemical patterns of rats exposed to chronic unpredictable stress

Qiu

Zhang

Mao

et al. 2013

Neuroscience Letters

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“…From the observations made in this study, it is evident that both MFI and MMF dose dependently suppress the stress-induced elevation in adrenal gland weight, corticosterone level, and modulate the altered brain monoamine (5-HT, NE, and DA) concentrations and oxidative stress. These observations are quite analogous to those made in foot-shock stressed rats reported by others (Ahmad et al 2012), and reveal adaptive effect of treatments on the neuroendocrine system through homeostasis of HPA-axis physiology via the higher centers of brain i.e., fontal cortex (FC), hippocampus (HIP), and hypothalamus (HYP). The highest tested daily doses of MFI (240 mg/kg/day) and MMF (5 mg/kg/day) had profound effects on stressinduced over expressions of cytokines in blood as well as in brain, and similar were also the observations made with 100 mg/kg daily doses of the adaptogenic herbal extract WS in this study.…”

Section: Discussionsupporting

confidence: 87%

Gastro-protective and Anti-stress Efficacies of Monomethyl Fumarate and a Fumaria indica Extract in Chronically Stressed Rats

et al. 2015

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Results of the very first experiments conducted to evaluate therapeutic potentials of a fumarate containing Fumaria indica extract and of fairly low daily oral doses of monomethyl fumarate for prevention of chronic unavoidable foot-shock stress-induced gastric ulcers, and possible involvement of diverse neuro-hormonal and oxidative process in their stress response desensitizing effects are reported and discussed in this article. Preventive effects of 21 daily oral 60, 120, and 240 mg/kg doses of a standardized 50 % methanolic F. indica extract (MFI) and 1.25, 2.50, and 5.00 mg/kg/day of pure monomethyl fumarate (MMF) were compared in rats subjected to one hour daily unavoidable foot-shocks. A pharmaceutically well-standardized Withania somnifera (WS) root extract was used as a reference herbal anti-stress agent in all experiments. Effects of the treatments on stress-induced alterations in body weight, adrenal and spleen weights, gastric ulcer and ulcer index, weight of glandular stomach, protective mucosal glycoprotein content, cellular proliferation, oxidative stress on stomach fundus, and brain tissues of male rats were quantified. Other parameters quantified were plasma corticosterone levels, brain monoamine levels, and expressions of the cytokines TNF-α, IL-10, and IL-1β in blood and brain of stressed and treated rats. Most but not every observed stress-induced anomalies were suppressed or completely prevented by both MFI and pure MMF treatments in dose-dependent manner. Qualitatively, the observed activity profiles of both of them were similar to those of WS dose tested. These results reveal that both MFI and MMF are potent gastro-protective agents against chronic unavoidable stress-induced ulcers and strongly suggest that they act as regulators or modulators of monoamine, corticosterone, and cytokine homeostasis.

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“…After a week of acclimatization, animals were randomly divided into two groups (n=8). Group 1 (control group) was not immobilized by a restraint cage and Group 2 (restraintstress group) was immobilized by a restraint cage (12 h/d to induce acute stress; as described by Ahmad et al (2012), Retana-Márquez et al (2003), and Prabsattroo et al (2015)), followed by weighing the body for 7 consecutive days.…”

Section: Animals and Stress Proceduresmentioning

confidence: 99%

Changes of testicular phosphorylated proteins in response to restraint stress in male rats

Arun

Burawat

Sukhorum

et al. 2016

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To investigate male reproductive parameters via changes of potential testicular protein markers in restraint-stress rats. Methods: Male Sprague-Dawley rats were divided into two groups (non-immobilized control and restraint-immobilized/stress groups, n=8 each group). The stress animals were immobilized (12 h/d) by a restraint cage for 7 consecutive days. All reproductive parameters, morphology and histology were observed and compared between groups. In addition, the expression of steroidogenic acute regulatory (StAR) and phosphotyrosine proteins (previously localized in Sertoli and late spermatid cells) in testicular lysate was assayed by immuno-Western blotting. Results: Testosterone level, sperm concentration and sperm head normality of stress rats were significantly decreased while the corticosterone level was increased as compared with the control (P<0.05). Histologically, stress rats showed low sperm mass in epididymal lumen and some atrophy of seminiferous tubules. Although the expression of testicular StAR protein was not significantly different between groups, changed patterns of the 131, 95, and 75 kDa testicular phosphorylated proteins were observed in the stress group compared with the control group. The intensity of a testicular 95-kDa phosphorylated protein was significantly decreased in stress rats. Conclusions: This study has demonstrated the alteration of testicular phosphorylated protein patterns, associated with adverse male reproductive parameters in stress rats. It could be an explanation of some infertility in stress males.

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Novel Ocimumoside A and B as anti-stress agents: Modulation of brain monoamines and antioxidant systems in chronic unpredictable stress model in rats

Cited by 36 publications

References 34 publications

Antidepressant-like effects of paeoniflorin on the behavioural, biochemical, and neurochemical patterns of rats exposed to chronic unpredictable stress

Antidepressant-like effects of paeoniflorin on the behavioural, biochemical, and neurochemical patterns of rats exposed to chronic unpredictable stress

Gastro-protective and Anti-stress Efficacies of Monomethyl Fumarate and a Fumaria indica Extract in Chronically Stressed Rats

Changes of testicular phosphorylated proteins in response to restraint stress in male rats

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