Novel optimized biopolymer-based nanoparticles for nose-to-brain delivery in the treatment of depressive diseases

Sorrentino, Alessandro; Cataldo, Antonino; Curatolo, Riccardo; Tagliatesta, Pietro; Mosca, Luciana; Bellucci, Stefano

doi:10.1039/d0ra04212a

Cited by 11 publications

(6 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is possible to release an epidermal therapy for long time with a single application, loading the hydrogel nanocomposite with specific drugs [ 15 ]. Furthermore, a proper investigation of biocompatibility must be carried out, although nanocarbon drug delivery systems have been extensively tested, and the same nanocarbon materials used in this paper were tested as drug delivery systems by our group, and we observed good biocompatibility, which was increased by a proper stabilizer [ 14 , 15 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

“…Among the natural polymers, chitosan and alginate have successfully been used in many fields [ 9 , 10 , 11 , 12 , 13 ]. They have been applied in environmental applications, as a matrix to remove pollutants, and extensively used in medical applications, such as for bioprinting and tissue engineering in regenerative medicine, as well as in drug delivery systems, as carriers for all kinds of drugs (e.g., proteins, antibiotics, vaccines) via different routes of administration, ranging from oral to nasal to cerebral [ 14 , 15 , 16 ]. Additionally, chitosan and alginate derivatives have been tested in order to verify their antioxidant and anti-inflammatory activities [ 17 , 18 , 19 , 20 ]; it has been demonstrated that these polysaccharides possess especially strong antioxidant activity, and their derivatives with polyphenols in particular induce an important antioxidant response.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

MacGyvered Multiproperty Materials Using Nanocarbon and Jam: A Spectroscopic, Electromagnetic, and Rheological Investigation

Cataldo

Pietra

Zappelli

et al. 2022

JFB

Self Cite

View full text Add to dashboard Cite

As part of a biopolymer matrix, pectin was investigated to obtain an engineered jam, due to its biodegradability. Only a few examples of pectin-based nanocomposites are present in the literature, and even fewer such bionanocomposites utilize nanocarbon as a filler—mostly for use in food packaging. In the present paper, ecofriendly nanocomposites made from household reagents and displaying multiple properties are presented. In particular, the electrical behavior and viscoelastic properties of a commercial jam were modulated by loading the jam with carbon nanotubes and graphene nanoplates. A new nanocomposite class based on commercial jam was studied, estimating the percolation threshold for each filler. The electrical characterization and the rheological measurements suggest that the behavior above the percolation threshold is influenced by the different morphology—i.e., one-dimensional or two-dimensional—of the fillers. These outcomes encourage further studies on the use of household materials in producing advanced and innovative materials, in order to reduce the environmental impact of new technologies, without giving up advanced devices endowed with different physical properties.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MacGyvered Multiproperty Materials Using Nanocarbon and Jam: A Spectroscopic, Electromagnetic, and Rheological Investigation

Cataldo

Pietra

Zappelli

et al. 2022

JFB

Self Cite

View full text Add to dashboard Cite

show abstract

“…The treatment of neurological disorders is a key obstacle due to the limited drug permeability and high selectivity of the blood–brain barrier (BBB) . Moreover, the decrease in drug molecules delivered to the brain due to delivery through the circulatory system is known to reduce bioavailability. − In recent years, drug delivery from the nose to brain (N2B) has come to the fore to improve patient survival rates and quality of life. Through the nasal route, drug molecules can directly reach the brain via one of the direct routes (the olfactory and/or trigeminal nerves) or indirectly via the central circulation. − Furthermore, nasal delivery allows for noninvasive and easy administration, helps avoid the first-pass effect, and potentially provides direct access to the CNS by circumventing the BBB .…”

Section: Introductionmentioning

confidence: 99%

Tadpole-Like Anisotropic Polymer/Lipid Janus Nanoparticles for Nose-to-Brain Drug Delivery: Importance of Geometry, Elasticity on Mucus-Penetration Ability

Okmen Altas,

Kalaycioglu,

Lifshiz-Simon

et al. 2024

Mol. Pharmaceutics

View full text Add to dashboard Cite

Asymmetric geometry (aspect ratio >1), moderate stiffness (i.e., semielasticity), large surface area, and low mucoadhesion of nanoparticles are the main features to reach the brain by penetrating across the nasal mucosa. Herein, a new application has been presented for the use of multifunctional Janus nanoparticles (JNPs) with controllable geometry and size as a noseto-brain (N2B) delivery system by changing proportions of Precirol ATO 5 and polycaprolactone compartments and other operating conditions. To bring to light the N2B application of JNPs, the results are presented in comparison with polymer and solid lipid nanoparticles, which are frequently used in the literature regarding their biopharmaceutical aspects: mucoadhesion and permeability through the nasal mucosa. The morphology and geometry of JPs were observed via cryogenic-temperature transmission electron microscopy images, and their particle sizes were verified by dynamic light scattering, atomic force microscopy, and scanning electron microscopy. Although all NPs showed penetration across the mucus barrier, the best increase in penetration was observed with asymmetric and semielastic JNPs, which have low interaction ability with the mucus layer. This study presents a new and promising field of application for a multifunctional system suitable for N2B delivery, potentially benefiting the treatment of brain tumors and other central nervous system diseases.

show abstract

“…There have been numerous reports of nanocarriers for NTBDD including liposomes, − nanostructured lipid carriers, , solid lipid nanocarriers, , nanoemulsions, , and polymeric nanoparticles. For the latter, a number of polymers have been utilized including natural polymers such as alginate and chitosan as well as synthetic polymers such as poly(lactic acid), polycaprolactone, and poly(lactic- co -glycolic acid) (PLGA) . However, nanoparticle NTBDD studies have been largely confined to liquid formulations, and in vivo experiments have employed animal models that have significant anatomical and physiological differences compared to the human nasal cavity.…”

Section: Introductionmentioning

confidence: 99%

A Cell-Based Nasal Model for Screening the Deposition, Biocompatibility, and Transport of Aerosolized PLGA Nanoparticles

Maaz,

Blagbrough,

De Bank

2024

Mol. Pharmaceutics

View full text Add to dashboard Cite

The olfactory region of the nasal cavity directly links the brain to the external environment, presenting a potential direct route to the central nervous system (CNS). However, targeting drugs to the olfactory region is challenging and relies on a combination of drug formulation, delivery device, and administration technique to navigate human nasal anatomy. In addition, in vitro and in vivo models utilized to evaluate the performance of nasal formulations do not accurately reflect deposition and uptake in the human nasal cavity. The current study describes the development of a respirable poly(lactic-co-glycolic acid) nanoparticle (PLGA NP) formulation, delivered via a pressurized metered dose inhaler (pMDI), and a cell-containing three-dimensional (3D) human nasal cast model for deposition assessment of nasal formulations in the olfactory region. Fluorescent PLGA NPs (193 ± 3 nm by dynamic light scattering) were successfully formulated in an HFA134a-based pMDI and were collected intact following aerosolization. RPMI 2650 cells, widely employed as a nasal epithelial model, were grown at the air–liquid interface (ALI) for 14 days to develop a suitable barrier function prior to exposure to the aerosolized PLGA NPs in a glass deposition apparatus. Direct aerosol exposure was shown to have little effect on cell viability. Compared to an aqueous NP suspension, the transport rate of the aerosolized NPs across the RPMI 2650 barrier was higher at all time points indicating the potential advantages of delivery via aerosolization and the importance of employing ALI cellular models for testing respirable formulations. The PLGA NPs were then aerosolized into a 3D-printed human nasal cavity model with an insert of ALI RPMI 2650 cells positioned in the olfactory region. Cells remained highly viable, and there was significant deposition of the fluorescent NPs on the ALI cultures. This study is a proof of concept that pMDI delivery of NPs is a viable means of targeting the olfactory region for nose-to-brain drug delivery (NTBDD). The cell-based model allows not only maintenance under ALI culture conditions but also sampling from the basal chamber compartment; hence, this model could be adapted to assess drug deposition, uptake, and transport kinetics in parallel under real-life settings.

show abstract

Novel optimized biopolymer-based nanoparticles for nose-to-brain delivery in the treatment of depressive diseases

Abstract: A valid option to bypass the obstacle represented by the blood–brain barrier (BBB) in brain delivery is the use of the unconventional intranasal route of administration.

Cited by 11 publications

References 59 publications

MacGyvered Multiproperty Materials Using Nanocarbon and Jam: A Spectroscopic, Electromagnetic, and Rheological Investigation

MacGyvered Multiproperty Materials Using Nanocarbon and Jam: A Spectroscopic, Electromagnetic, and Rheological Investigation

Tadpole-Like Anisotropic Polymer/Lipid Janus Nanoparticles for Nose-to-Brain Drug Delivery: Importance of Geometry, Elasticity on Mucus-Penetration Ability

A Cell-Based Nasal Model for Screening the Deposition, Biocompatibility, and Transport of Aerosolized PLGA Nanoparticles

Contact Info

Product

Resources

About