Novel PEGylated Amphiphilic Copolymers as Nanocarriers for Drug Delivery: Synthesis, Characterization and Curcumin Encapsulation

Kumar, Vijayendra; Gupta, Bhavna; Kumar, Gaurav; Pandey, Mukesh K.; Aiazian, Eric; Parmar, Virinder S.; Kumar, Jayant; Watterson, Arthur C.

doi:10.1080/10601325.2010.518549

Cited by 21 publications

(11 citation statements)

References 7 publications

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“…The encapsulation potential of the amphiphiles was determined for four different exemplary hydrophobic entities, the dye Nile red, and the three drugs nimodipine, curcumin and dexamethasone, all of which might interact with the nanocarriers through non-covalent interactions such as hydrophobic, p-p stacking and hydrogen bonding, employing either the lm method 47 or solid dispersion method. 48 The resulting calculations of the transport efficiency, transport capacity and encapsulation efficiency are presented in Table 2. Further, to get insight into the encapsulation process, drug/dye encapsulated samples were studied by DLS which revealed that there was no signicant change in size aer encapsulation of the hydrophobic guest molecules (Table 3 and Fig.…”

Section: Encapsulation Potentialmentioning

confidence: 99%

Fabrication of nanostructures through self-assembly of non-ionic amphiphiles for biomedical applications

et al. 2017

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Section: Encapsulation Potentialmentioning

confidence: 99%

Fabrication of nanostructures through self-assembly of non-ionic amphiphiles for biomedical applications

et al. 2017

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“…In order to further explore the host–guest properties, Nile red and nimodipine too, were used as model dyes/drugs for the solubilization experiments. The incorporation of all these chromophores in the amphiphilic systems was accomplished by either the film method or solid dispersion method . Following the encapsulation at a concentration of 5 mg mL −1 aqueous amphiphilic solution and 0.12/0.5/0.5 mg of Nile red/nimodipine/curcumin, the quantification of entrapped dye/drug was achieved by lyophilization of the encapsulated samples and dissolution in methanol (Nile red/curcumin)/ethanol (nimodipine), with subsequent measurement of their absorbance and fluorescence emission spectra.…”

Section: Resultsmentioning

confidence: 99%

Nonionic Dendritic and Carbohydrate Based Amphiphiles: Self‐Assembly and Transport Behavior

Prasad

Achazi

Schade

et al. 2018

Macromolecular Bioscience

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Herein, a new series of non-ionic dendritic and carbohydrate based amphiphiles is synthesized employing biocompatible starting materials and studied for supramolecular aggregate formation in aqueous solution. The dendritic amphiphiles 12 and 13 possessing poly(glycerol) [G2.0] as hydrophilic unit and C-10 and C-18 hydrophobic alkyl chains, respectively, exhibit low critical aggregation concentration (CAC) in the order of 10 m and hydrodynamic diameters in the 8-10 nm range and supplemented by cryogenic transmission electron microscopy. Ultraviolet-visible (UV-Vis) and fluorescence spectroscopy suggests the effective solubilization of hydrophobic guests by the self-assembled architectures, with the nanotransporters 12 and 13 possessing the highest encapsulation efficiency of 80.74 and 98.03% for curcumin. Efficient uptake of encapsulated curcumin in adenocarcinomic human alveolar basal epithelial (A549) cells is observed by confocal laser scanning microscopy. Amphiphiles 12 and 13 are non-cytotoxic at the concentrations studied, however, curcumin encapsulated samples efficiently reduce the viability of A549 cells in vitro. Experimental studies indicate the ability of amphiphile 13 to encapsulate 1-anilinonaphthalene-8-sulfonic acid (ANS) and curcumin with binding constant of 1.16 × 105 m and 1.43 × 10 m , respectively. Overall, our findings demonstrate the potential of these dendritic amphiphiles for the development of prospective nanocarriers for the solubilization of hydrophobic drugs.

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“…Polymers 6 and 7 ( Figure 5) could be used to encapsulate hydrophobic drugs, for example curcumin, in the range of 2.7-5.7 % with regard to polymer weight, thus enhancing its aqueous solubility. [34,35] Results from in vitro and animal studies suggested that curcumin has antitumoral, antioxidant, antiarthritic, antiamyloid, anti-ischemic, and anti-inflammatory properties. However, its low aqueous solubility delays its potential use.…”

Section: Nanomaterials For Drug and Gene Deliverymentioning

confidence: 99%

Novozym 435‐Catalyzed Syntheses of Polyesters and Polyamides of Medicinal and Industrial Relevance

et al. 2014

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The adverse impact of chemical and biochemical waste on the environment and human health poses a serious challenge in today's World. The best way to address these challenges is to reduce the waste by developing more efficient processes and technologies, based on the principles of "green chemistry". Some of these synthetic approaches involving the chemoenzymatic synthetic methodologies are discussed herein. These lead to the formation of unique nanomaterials with diverse applications, such as drugs/gene delivery systems, flame retardant materials, conducting polymers, controlled release systems, diagnostic agents, and polymeric electrolytes for nanocrystalline solar cells.

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Novel PEGylated Amphiphilic Copolymers as Nanocarriers for Drug Delivery: Synthesis, Characterization and Curcumin Encapsulation

Cited by 21 publications

References 7 publications

Fabrication of nanostructures through self-assembly of non-ionic amphiphiles for biomedical applications

Fabrication of nanostructures through self-assembly of non-ionic amphiphiles for biomedical applications

Nonionic Dendritic and Carbohydrate Based Amphiphiles: Self‐Assembly and Transport Behavior

Novozym 435‐Catalyzed Syntheses of Polyesters and Polyamides of Medicinal and Industrial Relevance

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