Novel PEPPSI-type N-heterocyclic carbene palladium(II) complexes: Synthesis, characterization, in silico studies and enzyme inhibitory properties against some metabolic enzymes

Yığıt, Beyhan; Taslimi, Parham; Celepci, Duygu Barut; Taşkın‐Tok, Tuğba; Yiğit, Murat; Aygün, Muhıttın; Özdemır, İsmaıl; Gülçın, İlhami

doi:10.1016/j.ica.2022.121239

Cited by 21 publications

(10 citation statements)

References 97 publications

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“…[41][42][43][44][45][46] In a recent study, we reported the synthesis of diisopropylamine-functionalized NHC-Pd(II) PEPPSI complexes, which demonstrated good inhibition effects against carbonic anhydrase I, II (hCAs I and II), and α-glycosidase enzymes. 47 In another study, reported by Özdemir, Ag(I) and Au(I) complexes of diisopropylamine-substituted benzimidazolium salts exhibited good anticancer activity against human cell lines, namely brain (SHSY5Y), colon (HTC 116), and liver (HEP3B). 48 In this study, we present the synthesis, antibacterial and antifungal activities of the diisopropylamine-substituted benzimidazolium salts and their respective Ag(I)-NHC complexes.…”

Section: Introductionmentioning

confidence: 94%

Silver(I) Complexes Bearing Amine-Functionalized N-Heterocyclic Carbenes: Synthesis, Antimicrobial and Theoretical Studies

Yiğit¹,

Yığıt²,

Akdan³

et al. 2023

HETEROCYCLES

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In this study, a series of amine functionalized benzimidazolium salts and their silver(I) N-heterocyclic carbene complexes were synthesized and characterized by FT-IR, 1 H NMR and 13 C NMR spectroscopy and mass spectrometry. All the compounds were evaluated for their antibacterial and antifungal activities. They showed antibacterial activity with MIC values in the range of 12.5-50 µg/mL and antifungal activity with MIC values in the range of 290

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Section: Introductionmentioning

confidence: 94%

Silver(I) Complexes Bearing Amine-Functionalized N-Heterocyclic Carbenes: Synthesis, Antimicrobial and Theoretical Studies

Yiğit¹,

Yığıt²,

Akdan³

et al. 2023

HETEROCYCLES

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“…Carbonic anhydrases (CAs) are metalloenzymes that contain Zn 2+ and catalyze the reversible hydration of carbon dioxide (CO 2 ) to protons and bicarbonate (HCO 3 − ) [ 35 , 36 ]. CAs play a variety of biochemical and metabolic roles, including ureagenesis, lipogenesis, and gluconeogenesis [ 37 , 38 , 39 ]. They also maintain a fluid balance throughout the body, particularly in the eyes, stomach, and kidneys.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Metabolite Profiling of Berdav Propolis Using LC-MS/MS: Determination of Antioxidant, Anticholinergic, Antiglaucoma, and Antidiabetic Effects

et al. 2023

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Propolis is a complex natural compound that honeybees obtain from plants and contributes to hive safety. It is rich in phenolic and flavonoid compounds, which contain antioxidant, antimicrobial, and anticancer properties. In this study, the chemical composition and antioxidant activities of propolis were investigated; ABTS•+, DPPH• and DMPD•+ were prepared using radical scavenging antioxidant methods. The phenolic and flavonoid contents of propolis were 53 mg of gallic acid equivalent (GAE)/g and 170.164 mg of quercetin equivalent (QE)/g, respectively. The ferric ion (Fe3+) reduction, CUPRAC and FRAP reduction capacities were also studied. The antioxidant and reducing capacities of propolis were compared with those of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), α-tocopherol and Trolox reference standards. The half maximal inhibition concentration (IC50) values of propolis for ABTS•+, DPPH• and DMPD•+ scavenging activities were found to be 8.15, 20.55 and 86.64 μg/mL, respectively. Propolis extract demonstrated IC50 values of 3.7, 3.4 and 19.6 μg/mL against α-glycosidase, acetylcholinesterase (AChE) and carbonic anhydrase II (hCA II) enzyme, respectively. These enzymes’ inhibition was associated with diabetes, Alzheimer’s disease (AD) and glaucoma. The reducing power, antioxidant activity and enzyme inhibition capacity of propolis extract were comparable to those demonstrated by the standards. Twenty-eight phenolic compounds, including acacetin, caffeic acid, p-coumaric acid, naringenin, chrysin, quinic acid, quercetin, and ferulic acid, were determined by LC-MS/MS to be major organic compounds in propolis. The polyphenolic antioxidant-rich content of the ethanol extract of propolis appears to be a natural product that can be used in the treatment of diabetes, AD, glaucoma, epilepsy, and cancerous diseases.

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“…Natural substances such as AChE inhibitors (AChEIs) have frequently been used in clinical trials, particularly for the treatment of AD. Phenolic substances served as the first drugs for the treatment of AD and were also discovered to be AChEIs [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Determination of Antioxidant, Anti-Alzheimer, Antidiabetic, Antiglaucoma and Antimicrobial Effects of Zivzik Pomegranate (Punica granatum)—A Chemical Profiling by LC-MS/MS

Karageçili

İzol

Kıreçcı

et al. 2023

Life

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Zivzik pomegranate (Punica granatum) has recently sparked considerable interest due to its nutritional and antioxidant properties. To evaluate the antioxidant capacities of P. granatum juice, ethanol (EEZP), and water (WEZP) extracts from peel and seed, the antioxidant methods of 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid radical (ABTS•+) scavenging, 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH•) scavenging, Fe3+-2,4,6-tris(2-pyridyl)-S-triazine (TPTZ) reducing, Fe3+ reducing, and Cu2+ reducing methods were used. The antioxidant capacities of samples were compared with the most commonly used synthetic antioxidants, i.e., BHA, BHT, α-tocopherol, and Trolox. In terms of setting an example, the IC50 values of EEZP for ABTS•+ and DPPH• scavenging activities were found to be lower than standards, at 5.9 and 16.1 μg/mL, respectively. The phenolic and flavonoid contents in EEZP peel were 59.7 mg GAE/g and 88.0 mg QE/g, respectively. Inhibition of α-glycosidase, α-amylase, acetylcholinesterase, and human carbonic anhydrase II (hCA II) enzymes was also investigated. EEZP demonstrated IC50 values of 7.3 μg/mL against α-glycosidase, 317.7 μg/mL against α-amylase, 19.7 μg/mL against acetylcholinesterase (AChE), and 106.3 μg/mL against CA II enzymes. A total of 53 phenolic compounds were scanned, and 30 compounds were determined using LC-MS/MS. E. coli and S. aureus bacteria were resistant to all four antibiotics used as standards in hospitals.

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Novel PEPPSI-type N-heterocyclic carbene palladium(II) complexes: Synthesis, characterization, in silico studies and enzyme inhibitory properties against some metabolic enzymes

Cited by 21 publications

References 97 publications

Silver(I) Complexes Bearing Amine-Functionalized N-Heterocyclic Carbenes: Synthesis, Antimicrobial and Theoretical Studies

Silver(I) Complexes Bearing Amine-Functionalized N-Heterocyclic Carbenes: Synthesis, Antimicrobial and Theoretical Studies

Comprehensive Metabolite Profiling of Berdav Propolis Using LC-MS/MS: Determination of Antioxidant, Anticholinergic, Antiglaucoma, and Antidiabetic Effects

Determination of Antioxidant, Anti-Alzheimer, Antidiabetic, Antiglaucoma and Antimicrobial Effects of Zivzik Pomegranate (Punica granatum)—A Chemical Profiling by LC-MS/MS

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