Novel peptides derived from egg white protein inhibiting alpha-glucosidase

Yu, Zhipeng; Yin, Yunfei; Zhao, Wenzhu; Yu, Yang; Liu, Boqun; Liu, Jingbo; Chen, Feng

doi:10.1016/j.foodchem.2011.05.067

Cited by 182 publications

(132 citation statements)

References 21 publications

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“…2 Sum of perirenal, epididymal, and mesenteric adipose tissue weight. 3 Sum of soleus, plantaris, gastrocnemius, tibialis anterior, and extensor digitorum longus muscles. 4 Values of homeostasis model assessment (HOMA) of IR (HOMA-IR) and insulin secretion (HOMA-b) were calculated using following formulae: HOMA-IR5fasting insulin (mIU/mL)3fasting glucose (mm)/22.5 and HOMA-b5203fasting insulin (mIU/mL)/(fasting glucose (mm)33.5).…”

Section: Exp C: Effect Of a Single Administration Of Ew And Ewh On LImentioning

confidence: 99%

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Egg White Hydrolysate Can Be a Low-Allergenic Food Material to Suppress Ectopic Fat Accumulation in Rats Fed an Equicaloric Diet

Ochiai

Misaki

Takeuchi

et al. 2017

J Nutr Sci Vitaminol

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Summary Egg white (EW) is known as a nutritional protein but can induce allergic reactions in humans. We investigated the dietary effects of EW and its hydrolysate (EWH), which contains less allergen, on body fat accumulation in Wistar rats fed an equicaloric high-fat and high-sucrose diet for 8 wk (Exp A). The pair-feeding of EW and equicaloric-feeding of EWH increased fecal fat excretion and suppressed lipid accumulation in the liver and muscles but not in the abdominal adipose tissues, carcass, or total body. Dietary EWH also suppressed the serum glucose level and alkaline phosphatase activity. Further, we showed a higher dispersibility of EW and EWH in physicochemical assay (Exp B). Next, we investigated the suppressive effects of a single administration of EW and EWH on lipid-induced hypertriglyceridemia and small intestinal meal transit in ddY mice (Exp C). However, a single administration of EW or EWH did not suppress the lipid-induced hypertriglyceridemia nor did it delay the rate of small intestinal transit. These findings indicated that dietary EW and EWH reduce hepatic and muscular (ectopic) fat accumulation mainly by suppressing fat absorption and supplying fat to the liver and muscles. Therefore, the low-allergenic EWH can be effective for the prevention of high-fat-diet-induced obesity.

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Section: Exp C: Effect Of a Single Administration Of Ew And Ewh On LImentioning

confidence: 99%

“…EW hydrolysate (EWH) obtained by protease treatment is expected to be soluble in water, to be more quickly digested and absorbed in the small intestine, and to have some higher nutritional values (3). However, few reports have investigated the nutritional effects of EWH.…”

mentioning

confidence: 99%

Egg White Hydrolysate Can Be a Low-Allergenic Food Material to Suppress Ectopic Fat Accumulation in Rats Fed an Equicaloric Diet

Ochiai

Misaki

Takeuchi

et al. 2017

J Nutr Sci Vitaminol

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“…Free radicals are molecule that has one or more unpaired electrons, which are unstable and highly reactive so can result in damage to cellular components such as DNA, proteins and other macromolecules [9]. Antioxidants are play therapeutic and preventive roles against several diseases include cancer, heart disease, cataracts, diabetes and liver.In general, animal products such as meat, milk and eggs are recognized as a source of bioactive compounds, including antioxidant [10]. The availability of antioxidants in eggs associated with the presence of several vitamins, including vitamin A, vitamin E, carotenoids, reduced glutathione, selenium and glutathione peroxidase that relates to embryonic development in the egg and the occurrence of stress during embryogenesis phase [11].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2017

JESR

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Abstract:Egg is a universal food in our regular diet which rich in many nutrients. The purpose of this study was to calculate approximately the proximate nutritional content and assess the physical appearance in variety of duck eggs produced in Bangladesh. Eggs have been collected from four region representing different geographic areas in Bangladesh. Proximate nutritional value of eggs has been analyzed according to AOAC method. Antioxidant activity was determined by Yen and Chen method. Farm duck contains the highest amount of moisture which is 71.18±0.04 % and Native duck contains the lowest amount of moisture which is 68.36±0.11%. On the other hand, Native duck contains the highest amount of fat (13.78±0.30%) and lowest ash 0.93±0.09%. Goose Shows highest amount of protein 13.86±0.56%, ash 1.13±0.07% and lowest amount of carbohydrate 2.98±0.34%. Energy has been calculated based on standard formula, where goose shows the highest energy (263.23 ±0.95 kcal) and farm duck shows the lowest amount (190.77±0.85 kcal). Goose shows maximum antioxidant activity 18.24% and Farm duck shows minimum antioxidant activity 14.32%. Native duck shows 16.46%, Chinese goose 16.78% antioxidant activity. Findings of this study will help to provide nutritional data in food composition table of Bangladesh and plays a significant role to eradicate the nutritional problem of the country.

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“…Due to this inhibitory activity, these hydrolysates can be utilised successfully in preparation of physiologically functional food, for diabetics. Novel peptides derived from egg white protein have been documented to have inhibitory action against α -glucosidase activity 31 and antidiabetic activity peptides from albumin against α -glucosidase and α -amylase have also been reported 22 . It is suggested that the inhibition of α-glucosidase results from multiple interactions of peptides with the enzyme 21 .…”

Section: Resultsmentioning

confidence: 99%

Glycemic Index Lowering Effect of Chicken Solids on Corn Starch

2017

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Glycemic index lowering effect of chicken solids was studied using a model system approach. Experimental samples were prepared by adding chicken powder at varying levels (10 mg, 20 mg, 30 mg, 40 mg) to 50 mg of corn starch as carbohydrate base. The chicken powder had a proximate protein content of 81.1 per cent, fat 9.1 per cent, ash 6 per cent and moisture 3.7 per cent. In vitro starch digestibility and estimated glycemic index (eGI) of the samples were estimated. It was found that only sample B and C could reduce the eGI of the sample by 22.8 per cent and 21.8 per cent respectively, with an eGI value of 68.05 and 68.9 respectively. Samples containing 30 mg and 40 mg chicken powder did not affect the eGI significantly and values were close to eGI values for the control (corn starch alone). It is concluded that chicken solids exhibit a significant (p < 0.05) glycemic index lowering effect at a level of 17 per cent to 29 per cent of the formulation, and not linearly with an increase in protein content.

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Novel peptides derived from egg white protein inhibiting alpha-glucosidase

Cited by 182 publications

References 21 publications

Egg White Hydrolysate Can Be a Low-Allergenic Food Material to Suppress Ectopic Fat Accumulation in Rats Fed an Equicaloric Diet

Egg White Hydrolysate Can Be a Low-Allergenic Food Material to Suppress Ectopic Fat Accumulation in Rats Fed an Equicaloric Diet

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Glycemic Index Lowering Effect of Chicken Solids on Corn Starch

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