Novel pH-sensitive hydrogels for 5-aminosalicylic acid colon targeting delivery:in vivostudy with ulcerative colitis targeting therapy in mice

Abstract

(2016) Novel pH-sensitive hydrogels for 5-aminosalicylic acid colon targeting delivery: invivo study with ulcerative colitis targeting therapy in mice, Drug Delivery, 23:6, 1926-1932, DOI: 10.3109/10717544.2014 The Central Hospital of Xi' an Huashan, Xi' an, China AbstractCurrent guidelines recommend patients with active and mild-to-moderate ulcerative colitis (UC), who have received initial therapy with 5-aminosalicylic acid (5-ASA). In this study, a novel drug delivery vehicle achieved by pH-sensitive hydrogels was applied to 5-ASA. In our previous work, a novel P(CE-MAA-MEG) pH-sensitive hydrogel was successfully synthesized by the heatinitiated free radical polymerization method. The aim of this study is to investigate its sitespecific delivering of drugs to the colon and evaluate its colon-targeting characteristic in vivo. 5-ASA was chosen as a model drug and successfully loaded in the hydrogel. In vitro investigations were carried out to evaluate its release process. Above all, animal treatment results reveal an obvious effect on the UC healing. Therefore, all results suggested that the developed 5-ASA-P(CE-MAA-MEG) hydrogel (5-ASA-GEL) as a colon-targeting vector might have a great potential application in the UC therapy.

Development and in vitro/in vivo evaluation of Zn-pectinate microparticles reinforced with chitosan for the colonic delivery of progesterone

“…Colon-specific drug delivery systems have gained increasing interest in the last decades due to the well-recognized importance of this region of the GIT, both for local and systemic administration of conventional and labile drugs (Yang et al, 2002;Maestrelli et al, 2008a;Bai et al, 2015). Drugs which are destroyed by the stomach acid or metabolized by pancreatic enzymes are minimally affected in the colon (Vervoort et al, 1998).…”

Nanoparticle-Based Oral Drug Delivery Systems Targeting the Colon for Treatment of Ulcerative Colitis

“…44 Most pH-sensitive materials have been found to be safe and have been used in the manufacture of gastro-resistant solid dosage forms, some of which are already available commercially. 45…”

Preparation and Evaluation of Diclofenac Sodium Tablet Coated with Polyelectrolyte Multilayer Film Using Hypromellose Acetate Succinate and Polymethacrylates for pH-Dependent, Modified Release Drug Delivery

“…There are several approaches for targeting drugs to colon, and each approach represents a distinct system in terms of design. Some colonic delivery systems utilize one or more triggering mechanisms to release the drug, such as gastrointestinal transit time-dependent delivery (2-5), pH-sensitive polymers (6), bacterial concentration, and pressure (7).…”