Novel phytoniosomes formulation of Tradescantia pallida leaves attenuates diabetes more effectively than pure extract

Imtiaz, Fariha; Islam, Muhammad; Saeed, Hamid; Ahmed, Abrar; Asghar, Maryam; Saleem, Bushra; Farooq, Muhammad Asim; Khan, Daulat Haleem; Peltonen, Leena

doi:10.1016/j.jddst.2023.104399

Journal of Drug Delivery Science and Technology

2023

DOI: 10.1016/j.jddst.2023.104399

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Novel phytoniosomes formulation of Tradescantia pallida leaves attenuates diabetes more effectively than pure extract

Fariha Imtiaz

Muhammad Islam

Hamid Saeed

et al.

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Cited by 5 publications

References 81 publications

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Synergistic anti‐cancer and antimicrobial effects of Ganoderma lucidum and Lentinus edodes mushroom extracts‐loaded niosomes

Zalnezhad,

Adeli‐Sardou,

Roostaee

et al. 2024

J Surfact & Detergents

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This study investigates the potential synergy effect of Ganoderma lucidum and Lentinus edodes mushroom extracts delivered through niosomes (composed of Span 40, Tween 40, and cholesterol) for anti‐cancer and antimicrobial applications. GC–MS analysis revealed bioactive compounds such as d‐limonene, ascorbic acid, and ergosterol in the extracts, known for their anti‐cancer and antimicrobial effects. The niosomal formulations exhibited improved physical properties, with sizes ranging from 96 to 160 nm and polydispersity index (PDI) values in the range of 0.29–0.54, suggesting that the niosomes had an acceptable size distribution and homogeneity. In cell culture studies, the niosomal formulations demonstrated significant cytotoxic effects on A549 lung cancer cells, with the combination of both extracts leading to a notable decrease in cell viability to 14.86%. Additionally, the combination of G. lucidum and L. edodes extracts in niosomal form showed varying and potent antimicrobial properties against pathogenic bacteria (Pseudomonas aeruginosa and Staphylococcus aureus) and fungi (Candida albicans) with lower minimum inhibitory concentration (MIC) values compared to their free form, indicating a potential synergistic effect. The findings highlight the potential synergistic anti‐cancer and antimicrobial effects of the combined mushroom extracts delivered through niosomes, offering valuable insights for developing novel drug delivery systems.

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Synergistic anti‐cancer and antimicrobial effects of Ganoderma lucidum and Lentinus edodes mushroom extracts‐loaded niosomes

Zalnezhad,

Adeli‐Sardou,

Roostaee

et al. 2024

J Surfact & Detergents

View full text Add to dashboard Cite

show abstract

Ultrasound-assisted extraction and encapsulation by spray drying of bioactive compounds from Tradescantia zebrina leaves

Feihrmann,

da Silva,

de Marins

et al. 2024

Food Chemistry Advances

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Bioassay-guided isolation and in silico study of antihyperlipidemic compounds from Onosma hispidum Wall

Saleem,

Islam,

Ahmed

et al. 2023

Journal of Biomolecular Structure and Dynamics

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Novel phytoniosomes formulation of Tradescantia pallida leaves attenuates diabetes more effectively than pure extract

Cited by 5 publications

References 81 publications

Synergistic anti‐cancer and antimicrobial effects of Ganoderma lucidum and Lentinus edodes mushroom extracts‐loaded niosomes

Synergistic anti‐cancer and antimicrobial effects of Ganoderma lucidum and Lentinus edodes mushroom extracts‐loaded niosomes

Ultrasound-assisted extraction and encapsulation by spray drying of bioactive compounds from Tradescantia zebrina leaves

Bioassay-guided isolation and in silico study of antihyperlipidemic compounds from Onosma hispidum Wall

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