Novel Polymer‐Supported Chiral Catalysts for the Asymmetric Addition of Diethylzinc to Aldehydes.

Abstract

Alcohols Q 0230 Novel Polymer-Supported Chiral Catalysts for the Asymmetric Addition of Diethylzinc to Aldehydes. -The catalyst can be recycled and reused without significant deterioration in performance. -(WANG, S.-X.; CHEN*, F.-E.; Chem.

A systematic study of chiral homoprolinols and their derivatives in the catalysis of enantioselective addition of diethylzinc to aldehydes

“…Since the first report by Oguni to use ( S )‐leucinol as chiral ligand in the addition of diethylzinc to benzadehyde with moderate enantiomeric excess,3 and Noyori's work with (‐)‐3‐exo‐(dimethylamino)isoborneol (DAIB) as chiral ligand,4–9 tremendous efforts have been focused on exploring new amino alcohols as efficient catalysts and diverse ligand structures have been developed to date 10–68. Among them, β‐amino alcohols have been studied extensively and proven to be the best ligands 10–23. Comparatively, γ‐amino alcohols have been studied less than β‐amino alcohols even though satisfactory results were achieved with the former ligands 24–35…”