Novel polyvinyl alcohol-bioglass 45S5 based composite nanofibrous membranes as bone scaffolds

Shankhwar, Nisha; Kumar, Manishekhar; Mandal, Biman B.; Srinivasan, A.

doi:10.1016/j.msec.2016.08.018

Cited by 37 publications

(21 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A comparison between composite 3D-ES samples shows that 5 wt% of BGs had no significant impact on the stiffness, differently from 10 wt% BGs that induced a 30% increase in the Young's modulus. Similar values of elastic modulus in tension have been reported for polymer-BGs scaffolds for bone tissue engineering, including: 60µm-thick PCL films containing 50 wt% of 45S5 bio-glasses (~200 MPa) [35], electrospun mats (80 µm thick) of polyvinyl alcohol and 45S5 BGs (~250 MPa) [36], and polydimethylsiloxane-BGs-PCL monoliths (230-330 MPa) [37].…”

Section: Analysis Of the Degradation Behaviour Of The Pcl-pgs-bgs Scasupporting

confidence: 71%

Multi-layer Scaffolds of Poly(caprolactone), Poly(glycerol sebacate) and Bioactive Glasses Manufactured by Combined 3D Printing and Electrospinning

2020

View full text Add to dashboard Cite

Three-dimensional (3D) printing has been combined with electrospinning to manufacture multi-layered polymer/glass scaffolds that possess multi-scale porosity, are mechanically robust, release bioactive compounds, degrade at a controlled rate and are biocompatible. Fibrous mats of poly (caprolactone) (PCL) and poly (glycerol sebacate) (PGS) have been directly electrospun on one side of 3D-printed grids of PCL-PGS blends containing bioactive glasses (BGs). The excellent adhesion between layers has resulted in composite scaffolds with a Young’s modulus of 240–310 MPa, higher than that of 3D-printed grids (125–280 MPa, without the electrospun layer). The scaffolds degraded in vitro by releasing PGS and BGs, reaching a weight loss of ~14% after 56 days of incubation. Although the hydrolysis of PGS resulted in the acidification of the buffer medium (to a pH of 5.3–5.4), the release of alkaline ions from the BGs balanced that out and brought the pH back to 6.0. Cytotoxicity tests performed on fibroblasts showed that the PCL-PGS-BGs constructs were biocompatible, with cell viability of above 125% at day 2. This study demonstrates the fabrication of systems with engineered properties by the synergy of diverse technologies and materials (organic and inorganic) for potential applications in tendon and ligament tissue engineering.

show abstract

Section: Analysis Of the Degradation Behaviour Of The Pcl-pgs-bgs Scasupporting

confidence: 71%

Multi-layer Scaffolds of Poly(caprolactone), Poly(glycerol sebacate) and Bioactive Glasses Manufactured by Combined 3D Printing and Electrospinning

2020

View full text Add to dashboard Cite

show abstract

“…Further, PVA/BG and PVA/MBG showed evidence of strong ion exchange with the pH of SBF reaching saturated values of 8.78, after 15 days of immersion. High pH values have been determined as necessary for new bone formation [122].…”

Section: Bonementioning

confidence: 99%

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

2019

View full text Add to dashboard Cite

Tissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. Amongst the many scaffolding techniques, electrospinning has gained widespread interest because of its outstanding features that enable the production of non-woven fibrous structures with a dimensional organization similar to the extracellular matrix. Various polymers can be electrospun in the form of three-dimensional scaffolds. However, very few are successfully processed using environmentally friendly solvents; poly(vinyl alcohol) (PVA) is one of those. PVA has been investigated for TE scaffolding production due to its excellent biocompatibility, biodegradability, chemo-thermal stability, mechanical performance and, most importantly, because of its ability to be dissolved in aqueous solutions. Here, a complete overview of the applications and recent advances in PVA-based electrospun nanofibrous scaffolds fabrication is provided. The most important achievements in bone, cartilage, skin, vascular, neural and corneal biomedicine, using PVA as a base substrate, are highlighted. Additionally, general concepts concerning the electrospinning technique, the stability of PVA when processed, and crosslinking alternatives to glutaraldehyde are as well reviewed.

show abstract

“…Its dissolution products have the ability to enhance the cell proliferation and activate the gene expression of osteoblasts (Xia et al, 2007). Therefore, BGs have been widely selected as bioactive components to be blended into various biodegradable electrospun polymers for bone tissue engineering applications, such as PCL/chitosan (Shalumon et al, 2013), PCL/gelatin (El-Fiqi et al, 2015) and PVA (Shankhwar et al, 2016), etc.…”

Section: Nano-composite Electrospun Fibers In Periodontal Regenerationmentioning

confidence: 99%

Advance of Nano-Composite Electrospun Fibers in Periodontal Regeneration

Lin

2019

Front. Chem.

View full text Add to dashboard Cite

Periodontitis is considered to be the main cause of tooth loss, which affects about 15% of the adult population around the world. Scaling and root-planning are the conventional treatments utilized to remove the contaminated tissue and bacteria, but eventually lead to the formation of a poor connection—long junctional epithelium. Therefore, regenerative therapies, such as guided tissue/bone regeneration (GTR/GBR) for periodontal regeneration have been attempted. GTR membranes, acting as scaffolds, create three-dimensional (3D) environment for the guiding of cell attachment, proliferation and differentiation, and play a significant role in periodontal regeneration. Nano-composite scaffolds based on electrospun nanofibers have gained great attention due to their ability to emulate natural extracellular matrix (ECM) that affects cell survival, attachment and reorganization. Promoted protein absorption, cellular reactions, activation of specific gene expression and intracellular signaling, and high surface area to volume ratio are also important properties of nanofibrous scaffolds. Moreover, several bioactive components, such as bioceramics and functional polymers can be easily blended into nanofibrous matrixes to regulate the physical-chemical-biological properties and regeneration abilities. Simultaneously, functional growth factors, proteins and drugs are also incorporated to regulate cellular reactions and even modify the local inflammatory microenvironment, which benefit periodontal regeneration and functional restoration. Herein, the progress of nano-composite electrospun fibers for periodontal regeneration is reviewed, including fabrication methods, compound types and processes, and surface modifications, etc. Significant proof-of-concept examples are utilized to illustrate the results of material characteristics, cellular interactions and periodontal regenerations. Finally, the existing limitations of nano-composite electrospun fibers and the development tendencies in future are also discussed.

show abstract

Novel polyvinyl alcohol-bioglass 45S5 based composite nanofibrous membranes as bone scaffolds

Cited by 37 publications

References 39 publications

Multi-layer Scaffolds of Poly(caprolactone), Poly(glycerol sebacate) and Bioactive Glasses Manufactured by Combined 3D Printing and Electrospinning

Multi-layer Scaffolds of Poly(caprolactone), Poly(glycerol sebacate) and Bioactive Glasses Manufactured by Combined 3D Printing and Electrospinning

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

Advance of Nano-Composite Electrospun Fibers in Periodontal Regeneration

Contact Info

Product

Resources

About