Novel Polyvinyl Pyrrolidone–Loaded Olopatadine HCl–Laden Doughnut Contact Lens to Treat Allergic Conjunctivitis

Xue, Yushun; Zhang, Wenzhi; Yan, Lei; Dang, Minyan

doi:10.1016/j.xphs.2020.01.022

Cited by 22 publications

(11 citation statements)

References 62 publications

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“…Application of PVP in contact lenses as a matrix component and/or as a wetting agent has been reported by multiple researchers [ 105 ]. Xue et al have developed a novel PVP K30 coated olopatadine-ethyl cellulose microparticles-laden doughnut contact lens [ 151 ]. They aimed for sustained ocular drug delivery with limited alteration in the optical transmittance and swelling characteristics of the contact lens.…”

Section: Pharmaceutical and Other Applicationsmentioning

confidence: 99%

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Kurakula

Rao

2020

Journal of Drug Delivery Science and Technology

292

172

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Polyvinylpyrrolidone (PVP) is a water-soluble polymer obtained by polymerization of monomer N -vinylpyrrolidone. PVP is an inert, non-toxic, temperature-resistant, pH-stable, biocompatible, biodegradable polymer that helps to encapsulate and cater both hydrophilic and lipophilic drugs. These advantages enable PVP a versatile excipient in the formulation development of broad conventional to novel controlled delivery systems. PVP has tunable properties and can be used as a brace component for gene delivery, orthopedic implants, and tissue engineering applications. Based on different molecular weights and modified forms, PVP can lead to exceptional beneficial features with varying chemical properties. Graft copolymerization and other techniques assist PVP to conjugate with poorly soluble drugs that can inflate bioavailability and even introduces the desired swelling tract for their control or sustained release. The present review provides chemistry, mechanical, physicochemical properties, evaluation parameters, dewy preparation methods of PVP derivatives intended for designing conventional to controlled systems for drug, gene, and cosmetic delivery. The past and growing interest in PVP establishes it as a promising polymer to enhance the trait and performance of current generation pharmaceutical dosage forms. Furthermore, the scrutiny explores existing patents, marketed products, new and futuristic approaches of PVP that have been identified and scope for future development, characterization, and its use. The exploration spotlights the importance and role of PVP in the design of Povidone-iodine (PVP–I) and clinical trials to assess therapeutic efficacy against the COVID-19 in the current pandemic scenario.

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Section: Pharmaceutical and Other Applicationsmentioning

confidence: 99%

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Kurakula

Rao

2020

Journal of Drug Delivery Science and Technology

292

172

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“…It was shown that the drug release effectiveness is directly proportional to the thickness of the drug film [ 118 , 119 , 120 ]. In vivo, sustained drug release was achieved when nonsteroid anti-inflammatory drugs were applied (12 h), two days for antibiotics and antihistamines, or seven days for corticosteroids [ 28 , 120 , 121 , 122 , 123 ].…”

Section: Drug Loading Techniquesmentioning

confidence: 99%

Soft Contact Lenses as Drug Delivery Systems: A Review

Rykowska

Nowak

Nowak³

2021

Molecules

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This review describes the role of contact lenses as an innovative drug delivery system in treating eye diseases. Current ophthalmic drug delivery systems are inadequate, particularly eye drops, which allow about 95% of the active substance to be lost through tear drainage. According to the literature, many interdisciplinary studies have been carried out on the ability of contact lenses to increase the penetration of topical therapeutic agents. Contact lenses limit drug loss by releasing the medicine into two layers of tears on either side of the contact lens, eventually extending the time of contact with the ocular surface. Thanks to weighted soft contact lenses, a continuous release of the drug over an extended period is possible. This article reviewed the various techniques to deliver medications through contact lenses, examining their advantages and disadvantages. In addition, the potential of drug delivery systems based on contact lenses has been extensively studied.

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“…Since pVP can absorb water, it also plays the role of a countermeasure against diarrhea in medicine [ 56 ]. As pVP has the ability of easily forming a film, it is used in contact lenses [ 57 , 58 ]. It has also been used as blood plasma substitute, but finally was replaced by another substance [ 59 , 60 ].…”

Section: Popular Biomedical Applications Of Pvpmentioning

confidence: 99%

Activity of Povidone in Recent Biomedical Applications with Emphasis on Micro- and Nano Drug Delivery Systems

2021

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Due to the unwanted toxic properties of some drugs, new efficient methods of protection of the organisms against that toxicity are required. New materials are synthesized to effectively disseminate the active substance without affecting the healthy cells. Thus far, a number of polymers have been applied to build novel drug delivery systems. One of interesting polymers for this purpose is povidone, pVP. Contrary to other polymeric materials, the synthesis of povidone nanoparticles can take place under various condition, due to good solubility of this polymer in several organic and inorganic solvents. Moreover, povidone is known as nontoxic, non-carcinogenic, and temperature-insensitive substance. Its flexible design and the presence of various functional groups allow connection with the hydrophobic and hydrophilic drugs. It is worth noting, that pVP is regarded as an ecofriendly substance. Despite wide application of pVP in medicine, it was not often selected for the production of drug carriers. This review article is focused on recent reports on the role povidone can play in micro- and nano drug delivery systems. Advantages and possible threats resulting from the use of povidone are indicated. Moreover, popular biomedical aspects are discussed.

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Novel Polyvinyl Pyrrolidone–Loaded Olopatadine HCl–Laden Doughnut Contact Lens to Treat Allergic Conjunctivitis

Cited by 22 publications

References 62 publications

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

Soft Contact Lenses as Drug Delivery Systems: A Review

Activity of Povidone in Recent Biomedical Applications with Emphasis on Micro- and Nano Drug Delivery Systems

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