Novel quaternary phosphonium-type cationic polyacrylamide and elucidation of dual-functional antibacterial/antiviral activity

Xue, Yan; Pan, Yuanfeng; Xiao, Huining; Zhao, Yuwei

doi:10.1039/c4ra08634a

Cited by 81 publications

(74 citation statements)

References 46 publications

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“…Moreover, a log reduction of 6.4 (4˝C) and 5.1 (22˝C) was observed for S. aureus ( Figure 3I-a) and E. coli ( Figure 3IV-b) respectively, after 24 h of contact. The results are in agreement with other published studies, where polymers with phosphonium salts exhibit strong antibacterial activity [27,28]. The homopolymer PVBCHAM-D2 (with covalently attached quaternary ammonium groups) showed a slight bacteriostatic effect at Gram-positive (S. aureus and E. faecalis) bacteria, with the greatest value (3.9 log reduction) observed after 24 h of contact at 4˝C for S. aureus ( Figure 3I-a).…”

Section: Antibacterial Activity Studiessupporting

confidence: 82%

Evaluation of Antimicrobial Efficiency of New Polymers Comprised by Covalently Attached and/or Electrostatically Bound Bacteriostatic Species, Based on Quaternary Ammonium Compounds

et al. 2015

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Abstract:In the present work a detailed study of new bacteriostatic copolymers with quaternized ammonium groups introduced in the polymer chain through covalent attachment or electrostatic interaction, was performed. Different copolymers have been considered since beside the active species, the hydrophobic/hydrophilic nature of the co-monomer was also evaluated in the case of covalently attached bacteriostatic groups, aiming at achieving permanent antibacterial activity. Homopolymers with quaternized ammonium/phosphonium groups were also tested for comparison reasons. The antimicrobial activity of the synthesized polymers after 3 and 24 h of exposure at 4 and 22˝C was investigated on cultures of Gram-negative (P. aeruginosa, E. coli) and Gram-positive (S. aureus, E. faecalis) bacteria. It was found that the combination of the hydrophilic monomer acrylic acid (AA), at low contents, with the covalently attached bacteriostatic group vinyl benzyl dimethylhexadecylammonium chloride (VBCHAM) in the copolymer P(AA-co-VBCHAM88), resulted in a high bacteriostatic activity against P. aeruginosa and E. faecalis (6 log reduction in certain cases). Moreover, the combination of covalently attached VBCHAM units with electrostatically bound cetyltrimethylammonium 4-styrene sulfonate (SSAmC 16 ) units in the P(SSAmC 16 -co-VBCHAMx) copolymers led to efficient antimicrobial materials, especially against Gram-positive bacteria, where a log reduction between 4.9 and 6.2 was verified. These materials remain remarkably efficient even when they are incorporated in polysulfone membranes.

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Section: Antibacterial Activity Studiessupporting

confidence: 82%

Evaluation of Antimicrobial Efficiency of New Polymers Comprised by Covalently Attached and/or Electrostatically Bound Bacteriostatic Species, Based on Quaternary Ammonium Compounds

et al. 2015

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“…Traditionally, incorporation of the antimicrobial agents into polymers is achieved by coating drug agents on the surface of polymers or physically entrapping the active agent within a polymer matrix [4]. However, majority of the antimicrobial agents steadily permeates out from the polymer matrices, giving rise to poisonous influences on the human body [5,6]. Polymerization of monomers possessing antimicrobial activity would eliminate the biocide-releasing problem, presenting long-term durability and environmentally friendly performance [7,8].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial/Antiviral Property and Mechanism of Dual-Functional Quaternized Pyridinium-type Copolymer

Xue

Xiao

2015

Polymers

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Due to the massive outbreaks of pathogen-caused diseases and the increase of drug-resistant pathogens, there is a particular interest in the development of novel disinfection agents with broad-spectrum antipathogenic activity.In the present study, water-soluble pyridinium-type polyvinylpyrrolidones with different counter anions were prepared. Structural characterization was conducted via 13 C-1 H heteronuclear single quantum coherence spectroscopy, static light scattering, UV spectrometry and apparent charge density. The influence of counter anion and polymer compositions on the antibacterial activity was studied against Staphylococcus aureus and Escherichia coli. Atomic force microscopy (AFM) was applied for tracking the morphological alterations in bacterial cells induced by prepared polycations. It was found that the exposure of bacteria to the polycations resulted in the destruction of cell membranes and the leakage of cytoplasm. The antiviral activity of pyridinium-type polycations against enveloped influenza virus was evaluated via a plaque assay. The action mode against enveloped virus was depicted to rationalize the antiviral mechanism.

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“…Applications include bone-tissue engineering [39], high proton conductivity in fuel cells [5], and hydrophilic-biocompatible polymers [40].…”

Section: Atrp An Lrp Methods Applied For Monomers With Different Phosmentioning

confidence: 99%

Recent advances in “living”/controlled radical polymerization of phosphorus-containing monomers and their potential applications

Zhang

Cheng

et al. 2015

Sci. China Chem.

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Special research attention has been paid to phosphorus-containing materials and their corresponding applications. This mini review considers recent publications devoted to the "living"/controlled radical (co)polymerization of phosphorus-containing monomers. In addition, different properties of the polymers involved in the phosphonate group in various chemical environments are demonstrated, and their potential applications are briefly discussed. living radical polymerization, nitroxide-mediated polymerization (NMP), atom transfer radical polymerization (ATRP), reversible addition-fragmentation chain transfer (RAFT), phosphorus-containing monomer

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Novel quaternary phosphonium-type cationic polyacrylamide and elucidation of dual-functional antibacterial/antiviral activity

Abstract: A novel quaternary phosphonium-type cationic polyacrylamide, which can kill bacteria by destroying the cell membrane, as well as inactivate adenovirus by blocking the viral entry, is developed.

Cited by 81 publications

References 46 publications

Evaluation of Antimicrobial Efficiency of New Polymers Comprised by Covalently Attached and/or Electrostatically Bound Bacteriostatic Species, Based on Quaternary Ammonium Compounds

Evaluation of Antimicrobial Efficiency of New Polymers Comprised by Covalently Attached and/or Electrostatically Bound Bacteriostatic Species, Based on Quaternary Ammonium Compounds

Antibacterial/Antiviral Property and Mechanism of Dual-Functional Quaternized Pyridinium-type Copolymer

Recent advances in “living”/controlled radical polymerization of phosphorus-containing monomers and their potential applications

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