Novel regression equations of left ventricular dimensions in infants less than 1 year of age and premature neonates obtained from echocardiographic examination

Nagasawa, Hiroyuki

doi:10.1017/s1047951110000661

Cited by 17 publications

(21 citation statements)

References 8 publications

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“…16 Nagasawa et al concluded length was an appropriate index for LVEDD in patients under age 1 year with only 32 patients less than 32 weeks gestation. 46 These prior studies did not utilize centile curves for LV dimensions.…”

Section: Discussionmentioning

confidence: 99%

Normative Left Ventricular M-Mode Echocardiographic Values in Preterm Infants up to 2 kg

Choudhry

Salter

Cunningham

et al. 2017

Journal of the American Society of Echocardiography

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Background There is a paucity of normative echocardiographic data in preterm infants. The objectives of this study were: (1) derive left ventricular (LV) M-mode reference values, and (2) compare the performance of alternative methods of indexing LV dimensions and mass (LVM) in preterm infants. We propose that indexing LV measures to weight in preterm infants is a practical approach given the variability associated with tape-measure length measurement in infants. Methods In this retrospective study LV M-mode echocardiographic measurements of end diastolic interventricular septal thickness (IVSd), end diastolic LV posterior wall thickness (LVPWd), LV end diastolic and systolic dimensions (LVEDD, LVESD), LVM, and relative wall thickness (RWT) were remeasured in 503 hospitalized preterm infants ≤ 2 Kg (372 from a retrospective sample and 131 prospectively enrolled). Measures for all variables did not differ between retrospective and prospective samples so results were pooled. LV dimensions and LVM indexed for weight, length, and body surface area (BSA) sex-specific centile curves and corresponding Z scores were generated using Cole’s lambda-mu-sigma method. Threshold limits (10th, and 80th percentile; P10, P80) were used to generate RWT normative range. Results Sex-specific centile curves using LVM, IVSd, LVPWd, LVEDD, and LVESD indexed to weight were similar to the curves generated using length and BSA. The mean [P10, P80] normal range for RWT was 0.33 (0.26, 0.38). Conclusions From this large cohort of preterm infants, we developed LV M-mode dimension and LVM centile curves indexed to weight as a practical method to assess LV morphology in preterm infants.

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Section: Discussionmentioning

confidence: 99%

Normative Left Ventricular M-Mode Echocardiographic Values in Preterm Infants up to 2 kg

Choudhry

Salter

Cunningham

et al. 2017

Journal of the American Society of Echocardiography

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“…16 LVDd% of normal (LVDd%N) 24 was calculated in percent as estimated LVDd, where estimated LVDd (in mm)=0.495× BH (in cm)-5.43. 18 To seek an easier but accurate correction of LAV4CV, we performed linear regression between LAV4CV and BH, and obtained the estimated LAV4CV by BH. Subsequently, we calculated LAV4CV %N.…”

Section: Discussionmentioning

confidence: 99%

“…We used indomethacin during the acute phase after 18 h of age in ELBWIs who showed no tendency for the PDA to close, who had a large left-to-right shunt, and who fulfilled some of the following criteria: (1) LA enlargement indicated by an LA/Ao ratio >1.3; (2) peak LPA edv >15 cm/s; (3) retrograde flow of renal arteries; and (4) LV end-diastolic dimension (LVDd) >≈120% of the normal estimated value. 18 Physical and ultrasonographic measurements were performed as an integral part of the routine clinical practice for ELBWIs in the NICU. The latter included obtaining informed consent from the patient's parents.…”

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confidence: 99%

Left Atrial Volume Is Superior to the Ratio of the Left Atrium to Aorta Diameter for Assessment of the Severity of Patent Ductus Arteriosus in Extremely Low Birth Weight Infants

Toyoshima

Masutani

Senzaki

et al. 2014

Circ J

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Background: This study was undertaken to establish the appropriate correction of left atrial volume (LAV) to body surface area (BSA) to provide reference values and to assess the hypotheses that LAV is useful for assessing patent ductus arteriosus (PDA) severity in extremely low birth weight infants (ELBWI) and could overcome the limitations of the LA-to-aortic dimension ratio (LA/Ao). Methods and Results:Echocardiograms with 318 data points from 53 consecutive ELBWIs were assessed. PDA surgery was performed within the first 2 weeks in 6 patients. LAV was measured using the biplane (LAV) and singleplane (LAV4CV) area-length methods. The allometric model was used to correlate LAV to BSA. LAV4CV had a good correlation with LAV (R=0.93). Although LAV/BSA 1 had a residual relationship with BSA, LAV/BSA 1.54 (23.5±9.3 ml/m 3.08 ) and LAV4CV/BSA 1.52 (21.4±9.4 ml/m 3.04 ) did not. Receiver-operating characteristic analysis to detect hemodynamic status just before PDA surgery showed the superiority of LAV/BSA 1.54 (area under the curve (AUC) 0.97) and LAV4CV/ BSA 1.52 (AUC 0.98) over LA/Ao (AUC 0.92). Moreover, LAV/BSA 1.54 and LAV4CV/BSA 1.52 were better correlated with left pulmonary arterial end-diastolic velocity than was LA/Ao. Conclusions:This study provided appropriate BSA correction of LAV and its reference values in ELBWIs. LAV indices may be superior to LA/Ao for PDA severity assessment. Measurement of single-plane LAV is easy, with similar usefulness to biplane LAV. (Circ J 2014; 78: 1701 -1709

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“…While echocardiography has long been used for assessments of the size of the heart in children, this study applied two-dimensional echocardiography to assess the development of left ventricular end-diastolic dimension (LVDd) and the rate of development by using height as an index in neonates during the late neonatal period and in infants with body heights less than 75 cm [1][2][3]. Linear relationship between height and LVDd were detectable, excluding neonates with physiological pulmonary hypertension.…”

Section: Introductionmentioning

confidence: 99%

“…The following were the objectives of this study: (1) to show the changes in the flatness ratio in the shortaxis view, (2) to assess the transition of the endocardiac circumference length of the internal margin of the left ventricle in the short-axis view in physiological pulmonary hypertension, (3) to compare real LVDds and normal LVDds that were estimated by the formula previously reported, and (4) to reveal what the real LVDds imply at this age.…”

Section: Introductionmentioning

confidence: 99%

Interpretation of left ventricular dimensions of neonates obtained from echocardiographic examinations during the early neonatal period

Nagasawa

2013

Journal of Neonatal-Perinatal Medicine

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BACKGROUND: In neonates without physiological pulmonary hypertension, left ventricular end-diastolic dimensions (LVDd) are determined with two-dimensional echocardiography and formulated equations. However, there has not been discussed the meanings of dimensions in early neonatal periods, although the short-axis view of the left ventricle is not round at this age. The objective of this study was to assess LVDd in neonates during early neonatal periods. METHODS:The study group consisted of 460 full-term neonates (230 boys; 230 girls) without congenital heart disease. The iE33 apparatus was employed to examine and measure the LVDds and the longest and shortest dimensions in the short-axis view. RESULTS: A significant difference was observed between the real LVDds and the estimated normal dimensions that were calculated from the formula; LVDd(mm) = 0.352×Ht(cm)+1.86, (P = 0.020). The mean LVDds were estimated to be 97% of the normal LVDds. The real LVDds were influenced by the angle formed by the real LVDds and the longest dimension. CONCLUSIONS: The real LVDds were shorter than normal LVDds. These findings establish normal values for LVDds in the early neonatal period.

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Novel regression equations of left ventricular dimensions in infants less than 1 year of age and premature neonates obtained from echocardiographic examination

Abstract: The regression equations reported in the previous studies cannot be applied to data obtained from infants. In addition, three different formulae, one for each group of infants by using height as an index can be usefully applied for practical purposes.

Cited by 17 publications

References 8 publications

Normative Left Ventricular M-Mode Echocardiographic Values in Preterm Infants up to 2 kg

Normative Left Ventricular M-Mode Echocardiographic Values in Preterm Infants up to 2 kg

Left Atrial Volume Is Superior to the Ratio of the Left Atrium to Aorta Diameter for Assessment of the Severity of Patent Ductus Arteriosus in Extremely Low Birth Weight Infants

Interpretation of left ventricular dimensions of neonates obtained from echocardiographic examinations during the early neonatal period

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