Novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer

Singh, Laishram Pradeepkumar; Kundu, Parag; Ganguly, Krishnendu; Mishra, Amartya; Swarnakar, Snehasikta

doi:10.1016/j.freeradbiomed.2007.04.027

Cited by 48 publications

(27 citation statements)

References 36 publications

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“…In addition, the association between the severity of gastric ulceration, up-regulated tissue lipoperoxidation, and TNF-α values was previously registered by Singh et al [45], who found that antioxidant treatment could alleviate alcohol-induced gastric ulceration. Upregulation of TNF-α was mostly depicted to be responsible for recurrence of healed ulcers [46].…”

Section: Discussionmentioning

confidence: 69%

Gastroprotective Effect of Nicorandil in Indomethacin and Alcohol-Induced Acute Ulcers

El‐Moselhy

Abdel-Hamid

Abdelraheim

2008

Appl Biochem Biotechnol

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Despite the fact that dietary habits and lifestyles are incredibly advancing, gastric ulceration is still a terrible complaint. Extensive use of non-steroidal anti-inflammatory drugs (NSAIDs) and alcohol, in addition to stress, are all predisposing factors for ulcers. Most medical treatments are always time consuming and not efficient or satisfactory to the patients. Cardiovascular patients always need NSAIDs, or mostly cannot quit alcohols, while using many cardiovascular drugs. We aim to study a possible benefit of a common nitrogen oxide donor, anti-anginal drug, nicorandil [N-(2-hydroxyethyl) nicotinamide nitrate ester], in managing acute gastric ulcers through studying its effect on some relevant intermediates to ulcerogenesis as lipid peroxidation, tumor necrosis factor-alpha (TNF-alpha), and nitric oxide (NO). In addition, gastric mucosal histology was studied to pursue the drug effects on tissue level. Our study revealed that both indomethacin and alcohol induced gastric ulcer mainly through up-regulation of gastric mucosal lipid peroxidation, local tissue inflammation, leukocytic infiltration, and necrosis. Both ulcerogens significantly elevated TNF-alpha and decreased NO, initiating ulcer formation. Nicorandil pretreatment depicted a higher preventive index in indomethacin- (89.8%) and alcohol-induced (77.7%) acute ulceration. On the tissue level, it also protected the gastric mucosa combating leukocyte infiltration and tissue congestion. Nicorandil protected tissue necrosis through decreasing oxidative stress, elevating NO levels, and down-regulating the ulcerogen-induced TNF-alpha elevation and improved sub-mucosal blood supply. We conclude that nicorandil may be a suitable bimodal treatment for cardiovascular patients who are at high risk of gastric ulcers by using variable analgesics to alleviate possible cardiac pain episodes, and probably frequent doses will offer a more established and long-lasting protection.

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Section: Discussionmentioning

confidence: 69%

Gastroprotective Effect of Nicorandil in Indomethacin and Alcohol-Induced Acute Ulcers

El‐Moselhy

Abdel-Hamid

Abdelraheim

2008

Appl Biochem Biotechnol

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“…MMP‐2 and MMP‐9 are gelatinases‐type enzymes and specifically regulate acute and chronic gastric ulcers [34] . Evidence has shown that ethanol would increase the expression of MMP‐2 and MMP‐9, resulting in acute gastric ulcer [19,34,35] . Analysing the expression of MMPs, AT‐III downregulated MMP‐2 and MMP‐9 expression through upregulating TIMP‐2 and TIMP‐1 expressions during the prevention of ethanol‐induced gastric ulcer (Figure 4b).…”

Section: Discussionmentioning

confidence: 98%

Gastroprotective activity of atractylenolide III from Atractylodes ovata on ethanol-induced gastric ulcer in vitro and in vivo

Wang

Chen

et al. 2010

Journal of Pharmacy and Pharmacology

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“…It appears as a pathologic lesion in digestive tract exposed to ulcerogenic agents. This disease was seen as a result of imbalance between invasive and defensive factors (2, 3). …”

Section: Introductionmentioning

confidence: 99%

“…Factors involved in gastric ulcer pathogenesis are free radical production, inhibition of cell proliferations, inflammatory cell infiltrations, and production of reactive oxygen spices from lipid peroxidation and protein oxidation (3). …”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Tragopogon Graminifolius DC Against Ethanol Induced Gastric Ulcer

Farzaei

Khazaei

Abbasabadei

et al. 2013

Iran Red Crescent Med J

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Background: Gastric ulcer is a serious digestive system problem and affects 5% to 10% of people during their life. Chemical antigastric ulcer drugs have side effect, cannot prevent recurrence of ulcer and also show drug interaction with many other medicaments. Tragopogon graminifolius DC.(TG) is a herb which is widely used in the west of Iran and traditionally consumed for the treatment of gastrointestinal disorders. TG was introduced as one of the most beneficial plants for digestive ulcer in Iranian traditional medicine. Objectives: The aim of the present study was to determine the acute toxicity and protective effect of hydroalcoholic extract of TG (HeTG) against ethanol induced gastric ulcer. Materials and Methods: Male Wistar rats were divided into five groups (n = 7). HeTG at the doses of 50, 100, and 150 mg/kg were administered orally for 15 days and gastric ulcer was induced by pure ethanol (1 ml/200gr body weight). Ulcer index and protective rate were calculated and histological changes were determined. Results: HeTG was nontoxic up to 2000 mg/Kg. Ulcer index decreased in extract groups significantly. Protective rates of HeTG were 48.94%, 46.39%, and 43.99% in 50, 100, and 150 mg/kg extract, respectively. 50 mg/kg HeTG group had higher protective effect. There was relatively normal cellular arrangement in HeTG groups. Conclusions: TG showed protective effect against ethanol induced gastric ulcer. This study confirmed traditional medicine claims of TG.

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Novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer

Cited by 48 publications

References 36 publications

Gastroprotective Effect of Nicorandil in Indomethacin and Alcohol-Induced Acute Ulcers

Gastroprotective Effect of Nicorandil in Indomethacin and Alcohol-Induced Acute Ulcers

Gastroprotective activity of atractylenolide III from Atractylodes ovata on ethanol-induced gastric ulcer in vitro and in vivo

Protective Effect of Tragopogon Graminifolius DC Against Ethanol Induced Gastric Ulcer

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