Protective Effect of Tragopogon Graminifolius DC Against Ethanol Induced Gastric Ulcer

Farzaei, Mohammad Hosein; Khazaei, Mozafar; Abbasabadei, Zahra; Feyzmahdavi, Maryam; Mohseni, Gholamreza

doi:10.5812/ircmj.7845

Cited by 19 publications

(16 citation statements)

References 13 publications

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“…The mice were evaluated until 48 hours for symptoms of toxicity and mortality. Mortality was not observed in two groups of mice (Farzaei et al, 2013).…”

Section: Methodsmentioning

confidence: 83%

Crab Shell Extract Improves Serum Biochemical Markers and Histological Changes of Pancreas in Diabetic Rats

2017

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MAKALANI, F.; KHAZAEI, M. R.; GHANBARI, E. & KHAZAEI, M.Crab shell extract improves serum biochemical markers and histological changes of pancreas in diabetic rats. Int. J. Morphol., 35(4):1437Morphol., 35(4): -1443Morphol., 35(4): , 2017 SUMMARY: Diabetes mellitus is a common metabolic disease. There are many natural agents available to control and treat diabetes. Crab shell extract has antioxidant properties. The aim of present study was to investigate the effect of crab shell hydroalcoholic extract on blood glucose, liver enzymes, nitric oxide and antioxidant capacity of serum and histological structure of pancreas in diabetic rats. In this experimental study, thirty five male Wistar rats (180-220 g) were divided into control, diabetic and experimental groups (n=7). Diabetes was induced by intraperitoneal injection of streptozotocin (60 mg/kg). Rats were treated for 14 days by crab shell extract with 100, 200 and 400 mg/kg doses. Fasting blood glucose, serum levels of liver enzymes, nitric oxide (NO) and total antioxidant capacity were evaluated. Changes of pancreatic tissue were determined using a modified aldehyde fuchsin staining method. Data were analyzed using one-way ANOVA. Differences were considered statistically significant at P<0.05. Crab shell extract induced a significant reduction in blood glucose, serum levels of nitric oxide and ALT (P=0.033). Also, there were a significant increase in total antioxidant capacity (FRAP) (P=0.007), and insignificant decrease in serum levels of AST. The extract improved pancreatic tissue changes caused by diabetes. In conclusion, antioxidant and anti-diabetic effects of crab shell increase total antioxidant capacity of serum and decreased blood glucose, serum nitric oxide and ALT levels.

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“…The mice were evaluated until 48 hours for symptoms of toxicity and mortality. Mortality was not observed in two groups of mice (Farzaei et al, 2013).…”

Section: Methodsmentioning

confidence: 83%

Crab Shell Extract Improves Serum Biochemical Markers and Histological Changes of Pancreas in Diabetic Rats

2017

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“…In TIM, a wide range of medicinal plants have been proposed for the treatment of different gastrointestinal disorders like inflammatory bowel disease, irritable bowel disease, hemorrhoids, and PU [84–87]. In this paper, all of edible fruits and spices claimed to be efficacious in the management of PU were collected from TIM sources, and any scientific evidence that prove their efficacy was retrieved from electronic databases.…”

Section: Discussionmentioning

confidence: 99%

Scientific Evaluation of Edible Fruits and Spices Used for the Treatment of Peptic Ulcer in Traditional Iranian Medicine

Farzaei

Shams-Ardekani

Abbasabadi

et al. 2013

ISRN Gastroenterology

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In traditional Iranian medicine (TIM), several edible fruits and spices are thought to have protective and healing effects on peptic ulcer (PU). The present study was conducted to verify anti-PU activity of these remedies. For this purpose, edible fruits and spices proposed for the management of PU in TIM were collected from TIM sources, and they were searched in modern medical databases to find studies that confirmed their efficacy. Findings from modern investigations support the claims of TIM about the efficacy of many fruits and spices in PU. The fruit of Phyllanthus emblica as a beneficial remedy for PU in TIM has been demonstrated to have antioxidant, wound healing, angiogenic, anti-H. pylori, cytoprotective, antisecretory, and anti-inflammatory properties. The fruit of Vitis vinifera has been found to be anti-H. pylori, anti-inflammatory, wound healing, angiogenic, cytoprotective, and antioxidant. The fruit and aril of seed from Myristica fragrans exert their beneficial effects in PU by increasing prostaglandin, modulation of nitric oxide and inflammatory mediators, wound healing, antisecretory, antacid, antioxidant, and anti-H. pylori activities, and improving angiogenesis. Pharmacological and clinical studies for evaluation of efficacy of all TIM fruits and spices in PU and their possible mechanisms of action are recommended.

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“…Different species of Tragopogon are used for their anticough, astringent, skin repairing, and vulnerary properties, and have beneficial effects in gastrointestinal disorders [4,5]. T. graminifolius aerial and root parts have been used in traditional Iranian medicine for their astringent, antiseptic, anti-inflammatory, poison elimination, anti-hemorrhagic, and wound healing activities, as well as a liver and stomach tonic, and for use in the treatment of gastrointestinal ulcers, liver disorders, haemorrhage, pulmonary infections, and wounds [6][7][8]. The plant is widely consumed in the west of Iran as a green vegetable in food and salads and also for medicinal purposes.…”

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confidence: 99%

Chemical Composition, Antioxidant and Antimicrobial Activity of Essential Oil and Extracts of Tragopogon graminifolius, a Medicinal Herb from Iran

Farzaei

Rahimi

Attar

et al. 2014

Natural Product Communications

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Tragopogon graminifolius DC., family Compositae, is widely consumed as a green vegetable in the west of Iran and for the treatment of gastrointestinal and hepatic ailments. In this study, the chemical composition of the essential oil from T. graminifolius aerial parts was evaluated by gas chromatography and gas chromatography mass spectrometry. Moreover, antioxidant and antimicrobial activity of the essential oil and various extracts of T. graminifolius were determined. Fifty-eight compounds representing 87.2% of the essential oil were identified. The main components were n-hexadecanoic acid (22.0%), βcaryophyllene (7.5%), heneicosane (6.6%), and nonanal (5.2%). The essential oil demonstrated the highest DPPH radical scavenging activity (56.6 ± 8.8ug/mL) and the 80% ethanolic extract the highest ferric reducing antioxidant activity (908.2±79.5 mmol Fe 2+ ion/g extract). The total phenolic content of the 80% ethanolic extract from the aerial parts was the highest (560.7±18.8 mg/g gallic acid equivalent). In the antimicrobial test, Shigella dysenteriae was the most vulnerable microorganism, followed by Proteus vulgaris, and the essential oil exhibited the highest antibacterial activity among the samples. The results indicated that the essential oil and extracts of T. graminifolius could be consumed as a natural herbal preservative or complementary supplement in the food and pharmaceutical industries.

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Protective Effect of Tragopogon Graminifolius DC Against Ethanol Induced Gastric Ulcer

Cited by 19 publications

References 13 publications

Crab Shell Extract Improves Serum Biochemical Markers and Histological Changes of Pancreas in Diabetic Rats

Crab Shell Extract Improves Serum Biochemical Markers and Histological Changes of Pancreas in Diabetic Rats

Scientific Evaluation of Edible Fruits and Spices Used for the Treatment of Peptic Ulcer in Traditional Iranian Medicine

Chemical Composition, Antioxidant and Antimicrobial Activity of Essential Oil and Extracts of Tragopogon graminifolius, a Medicinal Herb from Iran

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