Chemical Composition, Antioxidant and Antimicrobial Activity of Essential Oil and Extracts of <i>Tragopogon graminifolius</i>, a Medicinal Herb from Iran

Farzaei, Mohammad Hosein; Rahimi, Roja; Attar, Farideh; Siavoshi, Farideh; Saniee, Parastoo; Hajimahmoodi, Mannan; Mirnezami, Tahmineh; Khanavi, Mahnaz

doi:10.1177/1934578x1400900134

Cited by 21 publications

(23 citation statements)

References 18 publications

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“…Farzaei et al. reported the presence of five phenolic compounds including p -coumaric acid, ferulic acid, catechin, gallic acid and caffeic acid in the hydroalcoholic extract of T. graminifolius aerial parts 11 . TG essential oil contains n -hexadecanoic acid, β -caryophyllene, heneicosane and nonanal as major components.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds

Heidari

Bahramsoltani

Abdolghaffari

et al. 2019

Journal of Traditional and Complementary Medicine

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Tragopogon graminifolius DC. is a perennial plant from the family Asteraceae which grows in West parts of Iran. Several biological activities like antimicrobial, antioxidant and anti-inflammatory effects are reported for the plant. The aim of this study was to assess the wound healing activity of standardized extract from T. graminifolius (TG) aerial parts. Topical standardized TG extract with 5% and 10% concentrations in eucerine base was assessed for its healing properties on second degree burn in rats during a 14-day period. Biomarkers of oxidative damage including total antioxidant power, lipid peroxidation and total thiol molecules of the skin tissue samples were also evaluated. Results showed that 10%TG had the best efficacy with 80 ± 3% wound closure and tissue repair in comparison to negative control (p < 0.05). Significant reduction of tissue oxidative stress biomarkers was also observed. Histological analyses confirmed wound healing activity of TG extract, as well. Considering the antioxidative stress and anti-inflammatory activities of TG, explained by the high content of phenolic compounds of the plant, standardized TG extract could be considered as a natural remedy for the treatment of burn wounds. Further clinical studies are suggested to confirm the effectiveness of TG as a wound healing agent.

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Section: Introductionmentioning

confidence: 99%

Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds

Heidari

Bahramsoltani

Abdolghaffari

et al. 2019

Journal of Traditional and Complementary Medicine

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“…For example, palmitic acid was reported to be a more effective free radical scavenger than β-carotene [28]. n-Hexadecanoic acid may also contribute to the antioxidant activity [29].We have found that Phyllospora comosa (Crayweed), a species of brown algae in the Seirococcaceae family, has the highest level of polyphenols and also highest free radical scavenging activity. It also contains small amounts of fucoxanthin.…”

Section: Figmentioning

confidence: 95%

Assessment of antioxidant activity in Victorian marine algal extracts using high performance thin-layer chromatography and multivariate analysis

Agatonović-Kuštrin

Morton

Ristivojević³

2016

Journal of Chromatography A

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The aim of this study was to develop and validate a rapid and simple high performance thin layer chromatographic (HPTLC) method to screen for antioxidant activity in algal samples. 16 algal species were collected from local Victorian beaches. Fucoxanthin, one of the most abundant marine carotenoids was quantified directly from the HPTLC plates before derivatization, while derivatization either with 2,2-diphenyl-1-picrylhydrazyl (DPPH) or ferric chloride (FeCl) was used to analyze antioxidants in marine algae, based on their ability to scavenge non biological stable free radical (DPPH) or to chelate iron ions. Principal component analysis of obtained HPTLC fingerprints has classified algae species into 5 groups according to their chemical/antioxidant profiles. The investigated brown algae samples were found to be rich in non-and moderate-polar compounds and phenolic compounds with antioxidant activity. Most of the phenolic iron chelators also have shown free radical scavenging activity. Strong positive and significant correlations between total phenolic content and DPPH radical scavenging activity showed that, phenolic compounds, including flavonoids are the main contributors of antioxidant activity in these species. The results suggest that certain brown algae possess significantly higher antioxidant potential when compared to red or green algae and could be considered for future applications in medicine, dietary supplements, cosmetics or food industries. Cystophora monilifera extract was found to have the highest antioxidant concentration, followed by Zonaria angustata, Cystophora pectinate, Codium fragile, and Cystophora pectinata. Fucoxanthin was found mainly in the brown algae species. The proposed methods provide an edge in terms of screening for antioxidants and quantification of antioxidant constituents in complex mixtures. The current application also demonstrates flexibility and versatility of a standard HPTLC system in the drug discovery. Proposed methods could be used for the bioassay-guided isolation of unknown natural antioxidants and subsequent identification if combined with spectroscopic identification.

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“…The phytoconstituents of MO extract were identified based on the NIST and Wiley mass spectral library. 24,25…”

Section: Gas Chromatography-mass Spectrometric Analysismentioning

confidence: 99%

The Protective Effect ofMelissa officinalisL. in Visceral Hypersensitivity in Rat Using 2 Models of Acid-induced Colitis and Stress-induced Irritable Bowel Syndrome: A Possible Role of Nitric Oxide Pathway

Dolatabadi

Abdolghaffari

Farzaei

et al. 2018

J Neurogastroenterol Motil

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Background/AimsThe aim of present study is to estimate the effects of Melissa officinalis L. (MO) on visceral hypersensitivity (VH), defecation pattern and biochemical factors in 2 experimental models of irritable bowel syndrome (IBS) and the possible role of nitric oxide.MethodsTwo individual models of IBS were induced in male Wistar-albino rats. In the acetic acid model, the animals were exposed to rectal distension and abdominal withdrawal reflex, and the defecation patterns were determined. In the restraint stress model, the levels of TNF-α, myeloperoxidase, lipid peroxidation, and antioxidant powers were determined in the (removed) colon. Rats had been treated with MO, L-NG-nitroarginine methyl ester (L-NAME), aminoguanidine (AG), MO + AG, or MO + L-NAME in the mentioned experimental models.ResultsHypersensitive response to rectal distension and more stool defecation in control rats have been observed in comparison to shams. MO-300 significantly reduced VH and defecation frequency in comparison to controls. VH and defecation pattern did not show significant change in AG + MO and L-NAME + MO groups compared to controls. Also, significant reduction in TNF-α, myeloperoxidase, thiobarbituric acid reactive substances (TBARS), and an increase in antioxidant power in MO-300 group was recorded compared to controls. AG + MO and L-NAME + MO groups showed a reverse pattern compared to MO-300 group.ConclusionsMO can ameliorate IBS by modulating VH and defecation patterns. Antioxidant and anti-inflammatory properties along with its effect on the nitrergic pathway seem to play important roles in its pharmacological activity.

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Chemical Composition, Antioxidant and Antimicrobial Activity of Essential Oil and Extracts of Tragopogon graminifolius, a Medicinal Herb from Iran

Cited by 21 publications

References 18 publications

Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds

Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds

Assessment of antioxidant activity in Victorian marine algal extracts using high performance thin-layer chromatography and multivariate analysis

The Protective Effect ofMelissa officinalisL. in Visceral Hypersensitivity in Rat Using 2 Models of Acid-induced Colitis and Stress-induced Irritable Bowel Syndrome: A Possible Role of Nitric Oxide Pathway

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