Novel SA@Ca²⁺/RCSPs core–shell structure nanofibers by electrospinning for wound dressings

Abstract

Therapeutic drugs remain of great significance for the absorption of wound blood, the closure of wounds and rapid wound healing. Hence, we propose a novel composite nanofiber membrane with the above characteristics as a wound healing material. We utilize the reaction of calcium ion and alginate gel, sodium alginate (SA) and Rana chensinensis skin peptides (RCSPs) extracted from discarded Rana chensinensis skin; these two natural substances were successfully used to prepare composite nanofibers by coaxial electrospinning.

Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization

“…The healing rates of SA@Ca 2+ /RCSPs nanober treated wounds on days 5 and 15 were 46.65% and 97.46%, respectively. 127 Sundaran placed ampicillin-loaded chitosan microbeads into two layers of PCL electrospun bers to form a sandwich structure material Fig. 8 Characteristics of electrospun nanofibers and their applications in biological dressings.…”

Design and characterization of dual drug delivery based on in-situ assembled PVA/PAN core-shell nanofibers for wound dressing application

“…In the last years, dual drug delivery systems based on water-soluble and organic solvent-soluble drugs remaining the challenges when specific target required multiple medications 7–9 . Among the advanced methods, appropriate drug delivery systems have been designed based on co-axial or core-shell electrospun nanofibers 10,11 . However, the envisaged issues to prepare core-shell nanofibers are adjusting the supplied electrical voltage and polymers viscosity to obtain the uniformed nanofibers 12,13 .…”

A hybrid system of hydrogel/frog egg‐like microspheres accelerates wound healing via sustained delivery ofRCSPs

“…The nanofibers were applied to wound repair, proving that could undergo hemostasis rapidly, and promote wound healing. [20] However, the nanofibers became a gel as soon as they contact with a liquid, resulting in rapid release of the RCSPs. Here, we aim to develop a new drug delivery system that is comprised of a polyvinyl alcohol (PVA)/gelatin hydrogel matrix, including sodium alginate (SA) frog egg-like microspheres (FMS) for continuous delivery of RCSPs (Scheme 1).…”