Novel Self-Nano Emulsifying Drug Delivery System (SNEDDS) of andrographolide isolated from Andrographis paniculata Nees: Characterization, in-vitro and in-vivo assessment

Syukri, Yandi; Martien, Ronny; Lukitaningsih, Endang; Nugroho, Agung Endro

doi:10.1016/j.jddst.2018.06.014

Cited by 74 publications

(71 citation statements)

References 32 publications

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“…SEDDSs have beneficial capacities compared to conventional topical/transdermal drug delivery systems; for example, nano-emulsions and liposomes, as SEDDSs, are prone toward an enhanced drug-loading capacity, decreased drug concentrations with similar therapeutic effects due to improved drug delivery, as well as an evident lymphatic uptake that renders hepatic metabolism evasion [146][147][148][149][150]. The topical/transdermal route is readily considered, as it naturally avoids hepatic metabolism, but the lymphatic uptake of lipophilic drugs from the dermis skin layer is another advantageous targeted treatment angle that can successfully render SEDDS the leading agents in topical/transdermal drug delivery [6,12]. The dermal lymphatic drug delivery principle can furthermore aid in diseases worsened by lymphatic dissemination, for example, human immunodeficiency virus (HIV), metastatic cancers, and endogenous extra-pulmonary TB [151].…”

Section: Resultsmentioning

confidence: 99%

“…Thus, the lipid-altering potential, along with droplet refinement potential, of surfactants can assist in the successful delivery of topical/transdermal SEDDSs [58,111,112,114]. Likewise, finer droplets comprising lipophilic drugs have demonstrated an increased affinity for subcutaneous lymphatic uptake and could assist in avoiding metabolic processes within the dermis [6,12]. The ideal range for subcutaneously injected substances considered suitable for lymphatic absorption is between 80-100 nm [6].…”

Section: Evaluation Of Droplet Sizes Zeta Potential and Polydispersmentioning

confidence: 99%

“…More significantly, the high amounts of surfactants included in these formulations may induce gastrointestinal irritation, which may also be problematic if topical/transdermal drug delivery is to be deliberated [3,6,11]. On the other hand, the smaller average oil droplet size enhances drug bioavailability, which is due to an increased surface area [12,13]. SNEDDS have also been found to naturally circumvent first-pass metabolism due to lymphatic absorption [6].…”

Section: Introductionmentioning

confidence: 99%

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Development of Topical/Transdermal Self-Emulsifying Drug Delivery Systems, Not as Simple as Expected

2020

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Self-emulsifying drug delivery systems (SEDDSs) originated as an oral lipid-based drug delivery system with the sole purpose of improving delivery of highly lipophilic drugs. However, the revolutionary drug delivery possibilities presented by these uniquely simplified systems in terms of muco-adhesiveness and zeta-potential changing capacity lead the way forward to ground-breaking research. Contrarily, SEDDSs destined for topical/transdermal drug delivery have received limited attention. Therefore, this review is focused at utilising principles, established during development of oral SEDDSs, and tailoring them to fit evaluation strategies for an optimised topical/transdermal drug delivery vehicle. This includes a detailed discussion of how the authentic pseudo-ternary phase diagram is employed to predict phase behaviour to find the self-emulsification region most suitable for formulating topical/transdermal SEDDSs. Additionally, special attention is given to the manner of characterising oral SEDDSs compared to topical/transdermal SEDDSs, since absorption within the gastrointestinal tract and the multi-layered nature of the skin are two completely diverse drug delivery territories. Despite the advantages of the topical/transdermal drug administration route, certain challenges such as the relatively undiscovered field of skin metabolomics as well as the obstacles of choosing excipients wisely to establish skin penetration enhancement might prevail. Therefore, development of topical/transdermal SEDDSs might be more complicated than expected.

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Section: Resultsmentioning

confidence: 99%

Section: Evaluation Of Droplet Sizes Zeta Potential and Polydispersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of Topical/Transdermal Self-Emulsifying Drug Delivery Systems, Not as Simple as Expected

2020

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“…The SNEDDS of nystatin was found to be able to improve dissolution as well as oral antifungal efficacy (Kassem et al, 2016). Another study revealed that, compared to the plain formulation, the andrographolide isolated from Andrographis paniculata plant in the form of SNEDDS formulation provided better bioavailability and dissolution (Syukri et al, 2018).…”

mentioning

confidence: 99%

“…A regular droplet size after dilutions shows the possible uniformity of in vivo drug release. Thus, the preparations might have the capability of anticipating gradual dilution in the GI tract (Syukri et al, 2018).…”

mentioning

confidence: 99%

Formulation, Characterization and Stability of Ibuprofen-Loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS)

Syukri

Fitriani

Pandapotan

et al. 2019

Indonesian J. Pharm.

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Ibuprofen is a poorly water-soluble drug with analgesic, antipyretic and anti-inflammatory effects. Self-Nano Emulsifying Drug Delivery System (SNEDDS) formulation is a solution to improve the solubility and bioavailability of ibuprofen. This research purposed to perform a formulation, characterization, and stability studies of ibuprofen-loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS). Screening of ibuprofen SNEDDS was prepared by ternary diagrams for the chosen co-surfactants, surfactants, and oil. The following was characterizations of droplet size, zeta potential, and clarity. The solubility test for the determination of cosurfactant, surfactant, and oil obtained Propylene glycol monocaprylate (Capryol-90), Polysorbate 20 (Tween 20) and PEG 400. The screening of SNEDDS showed nine formulas (compositions) in the range concentration of Propylene glycol monocaprylate (1-3mL), Polysorbate 20 (4-8mL), and PEG 400 (1-3mL). The composition of Propylene glycol monocaprylate (1-2mL), Polysorbate 20 (5-8mL) and PEG 400 (1-3mL) passed the thermodynamic stability test. The test of robustness to dilution and stability study indicated that the formula with Propylene glycol monocaprylate, Polysorbate 20 and PEG 400 with the ratio of 1: 8: 1 and 1: 7: 2 was more stable. In conclusion, the stable ibuprofen SNEDDS could be prepared with Propylene glycol monocaprylate, Polysorbate 20, and PEG 400.

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Pharmacokinetics and repeated dose 28‐day oral toxicity studies of acetaminophen nanosuspension

Karami,

Bidgoli,

Saghatchi Zanjani

et al. 2023

J Biomed Mater Res

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Wide availability and easy accessibility of acetaminophen oral dosage forms increase the risk of intentional poisoning or unintentional organ toxicity, leading to a wide range of liver failure, nephrotoxicity, and neurotoxicity. In this study, an attempt was made to improve oral bioavailability and reduce the toxicity of acetaminophen using nanosuspension technology. The acetaminophen nanosuspensions (APAP‐NSs) were prepared by a nano‐precipitation method using polyvinyl alcohol and hydroxypropylmethylcellulose as stabilizers. The mean diameter of APAP‐NSs was 124 ± 3.8 nm. The dissolution profile of APAP‐NSs was significantly point‐to‐point higher than the coarse drug in simulated gastrointestinal fluids. The in vivo study revealed 1.6‐ and 2.8‐fold increases in the AUC0‐inf and Cmax of the drug, respectively, in APAP‐NSs‐receiving animals compared to the control group. Moreover, no deaths and no abnormalities in clinical signs, body weights, and necropsy findings were detected in the dose groups up to 100 mg/kg of the 28‐day repeated oral dose toxicity study in mice.

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Novel Self-Nano Emulsifying Drug Delivery System (SNEDDS) of andrographolide isolated from Andrographis paniculata Nees: Characterization, in-vitro and in-vivo assessment

Cited by 74 publications

References 32 publications

Development of Topical/Transdermal Self-Emulsifying Drug Delivery Systems, Not as Simple as Expected

Development of Topical/Transdermal Self-Emulsifying Drug Delivery Systems, Not as Simple as Expected

Formulation, Characterization and Stability of Ibuprofen-Loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS)

Pharmacokinetics and repeated dose 28‐day oral toxicity studies of acetaminophen nanosuspension

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