Formulation, Characterization and Stability of Ibuprofen-Loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS)

Syukri, Yandi; Fitriani, Hannie; Pandapotan, Herianto; Nugroho, Bambang Hernawan

doi:10.14499/indonesianjpharm30iss2pp105-113

Cited by 23 publications

(23 citation statements)

References 19 publications

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“…It is required to guarantee that the formed nanoemulsion does not precipitate out in the digestive tract. 16 The generally recognized as safe category has become the main criterion to consider when selecting emulsifier and co-emulsifier since these materials have to be pharmaceutically acceptable for oral administration. Another consideration is that the required hydrophilic-lipophilic balance (HLB) value to form o/w emulsion has to be more than 10.…”

Section: Resultsmentioning

confidence: 99%

Development of New Indonesian Propolis Extract-Loaded Selfemulsifying: Characterization, Stability and Antibacterial Activity

et al. 2020

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This study aimed to prepare, characterize, examine the stability and evaluation of the antibacterial activity of Indonesian propolis extract-loaded self-emulsifying (PESE). Methods: Oil, emulsifier, and co-emulsifier were selected as the carrier for the PESE formulation through a propolis-extract solubility test on each carrier, followed by evaluation of the nanoemulsion region in a pseudo ternary phase diagram. Pre-concentrate of PESE was prepared with the addition of 150 mg/mL propolis extract followed by characterization for the transmittance, globule size, zeta potential, thermodynamic stability, robustness to dilution, and accelerated stability. The selected formulation was tested for antibacterial activity using a microdilution method. Results: The PESE characterization produced a clear nanoemulsion with a globule size ranging from 13 to 45 nm and zeta potential of less than −38 mV. The PESE formulation with a composition of 150 mg/mL propolis extract, 20% castor oil, 40%-70% Kolliphor EL, and 10%-40% polyethylene glycol (PEG) 400 were thermodynamically stable. The PESE formulation with the composition of 20% castor oil, 40% Kolliphor EL, and 40% PEG 400 was the optimum formulation that passed the robustness to dilution evaluation and an accelerated stability test for 3 months. The antibacterial activity test on this formulation indicated improved activity against Escherichia coli and Staphylococcus aureus compared with that of propolis extract. Conclusion: These studies demonstrated that PESE in optimum formulation could be used as an antibacterial, particularly in E. coli and S. aureus.

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Section: Resultsmentioning

confidence: 99%

Development of New Indonesian Propolis Extract-Loaded Selfemulsifying: Characterization, Stability and Antibacterial Activity

et al. 2020

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“…PE solubility test in carriers is essential to obtain a stable formulation. It is required to guarantee that the formed nanoemulsion does not precipitate out in the digestive tract ( Syukri et al, 2019b ). The generally recognized as safe (GRAS) category has become the main criterion to consider when selecting emulsifier and co-emulsifier since these materials have to be pharmaceutically acceptable for oral administration.…”

Section: Discussionmentioning

confidence: 99%

“…SNEDDS formulations consist of the oil phase, surfactant, and co-surfactant ( Syukri et al, 2019a ). Capryol-90 has been widely used in the formulation of SNEDDS preparations and is proven to be the best solvent for substances that are less soluble in water ( Syukri et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

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Design and characterization of propolis extract loaded self-nano emulsifying drug delivery system as immunostimulant

Fitria

Hanifah

Chabib

et al. 2021

Saudi Pharmaceutical Journal

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This current study aims to optimize, characterize, and observe the stability of the self-nano emulsifying drug delivery system (SNEDDS) of propolis extract (PE) for improving the immune response. Optimization of the selected composition of SNEDDS was conducted using a D-optimal mixture design. SNEDDS was prepared by loading 150 mg/mL of PE in oil, surfactant, and cosurfactant phases. The thermodynamic stability test was carried out with phase separation parameters followed by the robustness to dilution and accelerated stability test. The immunostimulant activity was examined in vitro and in vivo by determining the phagocytic activity, cell proliferation, production of nitrite oxide levels of RAW 264.7 cells, phagocytic activity of macrophages, and the number of leukocytes, neutrophils, and lymphocytes. The formula optimization showed that the formula containing Capryol-90, Cremophor RH40, and PEG 400 at a ratio of 30: 34: 36 was optimum. The verification response of the optimum formula with drug loading showed that the transmittance, droplet size, and zeta potential were 96.90 ± 0.00%, 28.7 ± 1.20 nm, and −56.5 ± 2.05 mV, respectively. The thermodynamic stability test and robustness to dilution did not find any separation phase. The accelerated stability test results were classified as stable. The in vitro and in vivo immunostimulant activity test showed that PE-loaded SNEDDS exhibited a higher immunostimulant effect than PE. In conclusion, the optimum and stable composition of PE loaded SNEDDS was found with a simple and accurate method using the D-Optimal mixture design and demonstrated an immunostimulant activity.

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“…Percent of transmittance was used to observe the self-emulsification process by measuring the transmittance of the solution during dissolution as the emulsification process happened [7]. Table 2 shows composition 1, 4 (T80PGMZ) 92,1147%, 91,1998% and 15 (T20PGMZ) 87,407%, 86,9661% have clear dispersion with almost 100% clarity, indicating fulfillment of the nanoemulsion requirement [14]. As shown in Fig.…”

Section: Magfirah and Utamimentioning

confidence: 99%

Optimization and Characterization of Formulation Self-Nanoemulsifying Drug Delivery System Ethanol Extract of Romang Parang Leaves (Boehmeria Virgata)

Magfirah¹,

Utami²

2021

Asian J Pharm Clin Res

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Objective: Parang romang (Boehmeria virgata) is one of the traditional medicines that are used empirically by Makassar tribal healers, South Sulawesi, as an antitumor drug. This traditional medicine contains secondary metabolites such as alkaloids, flavonoids, tannins, and saponins. However, secondary metabolites of those leaves extract have low solubility in water. Hence, to be formula, self-nanoemulsifying drug delivery system (SNEDDS) is one of the solutions to increase the extract solubility. Methods: The optimization of two formula optimum SNEDDS parang romang leaves (T80PGMZ and T20PGMZ) was using the simple lattice design (SLD) method which will give 28 SNEDDS formula parang romang leaves each of which the formula is tested for its characteristics as a critical point include emulsification time, % transmittance, drug loading, particle size, zeta potential, polydispersity index, and morphology particle. Results: The results of SNEDDS characterization obtained the optimum formula T80PGMZ with emulsification time 12.6 s, % transmittance 92.21%, drug loading 68.21 ppm, particle size 370.26 nm, zeta potential −31.4 mV, polydispersity index of 0.615, and regular particle morphology with spherical chunks at a magnification of 10,000 times with a particle size of 10 μm. Conclusion: SNEDDS of parang romang leaves extracts that used olive oil as oil phase, Tween 80 as a surfactant, and propylene glycol as the cosurfactant provided nanoemulsion with good characteristics.

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Formulation, Characterization and Stability of Ibuprofen-Loaded Self-Nano Emulsifying Drug Delivery System (SNEDDS)

Cited by 23 publications

References 19 publications

Development of New Indonesian Propolis Extract-Loaded Selfemulsifying: Characterization, Stability and Antibacterial Activity

Development of New Indonesian Propolis Extract-Loaded Selfemulsifying: Characterization, Stability and Antibacterial Activity

Design and characterization of propolis extract loaded self-nano emulsifying drug delivery system as immunostimulant

Optimization and Characterization of Formulation Self-Nanoemulsifying Drug Delivery System Ethanol Extract of Romang Parang Leaves (Boehmeria Virgata)

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