Novel sesterterpenoid and norsesterterpenoid RCE-protease inhibitors isolated from the marine sponge Hippospongia sp.

Craig, Kyle S.; Williams, David E.; Hollander, Irwin; Frommer, Eileen; Mallon, Robert; Collins, Karen; Wojciechowicz, Donald; Tahir, Akbar; Soest, R.W.M. van; Andersen, Raymond J.

doi:10.1016/s0040-4039(02)00896-1

Cited by 36 publications

(29 citation statements)

References 8 publications

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“…Some of these have been found to possess several kinds of biological activities, such as isocitrate lyase (ICL) inhibitory [14], RCE protease inhibitory [15] and cytotoxic [16,17,18,19,20,21] activities. In the present study, two new sesterterpenoids, hippospongides A and B ( 1 and 2 ), together with six known scalarane sesterterpenoids were isolated from the sponge Hip pospongia sp .…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.

et al. 2012

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One new pentacyclic sesterterpene, hippospongide A (1), and one new scalarane sesterterpenoid, hippospongide B (2), along with six previously reported known scalarane–type sesterterpenes (3–8), were isolated from a sponge Hippospongia sp. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. These metabolites are the first pentacyclic sesterterpene and scalarane-type sesterterpenes to be reported from this genus. Compounds 3–5 exhibited significant cytotoxicity against DLD-1, HCT-116, T-47D and K562 cancer cell lines.

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Section: Discussionmentioning

confidence: 99%

Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.

et al. 2012

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“…306 Four new cytotoxic bisannulated acridines 5-methoxyneoamphimedine 328, neoamphimedine Y 329, neoamphimedine Z 330, and alpkinidine 331 were isolated from Xestospongia cf. 357 All compounds were found to inhibit the protease activity of human RAS converting enzyme (hRCE1) and are the first natural products reported with this activity. carbonaria (328)(329)(330)(331).…”

Section: Spongesmentioning

confidence: 99%

Marine natural products

et al. 2004

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This review covers the literature published in 2002 for marine natural products, with 579 citations (413 for the period January to December 2002) referring to compounds isolated from marine microorganisms and phytoplankton, green algae, brown algae, red algae, sponges, coelenterates, bryozoans, molluscs, tunicates and echinoderms. The emphasis is on new compounds (677 for 2002), together with their relevant biological activities, source organisms and country of origin. Syntheses that lead to the revision of structures or stereochemistries have been included (114), including any first total syntheses of a marine natural product.

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“…Using a fluorescence-based assay for hRCE1 developed by Hollander and coworkers [278], a number of structurally related terpenoids were isolated from the marine sponge Hippospongia sp. that inhibit the protease activity of hRCE1 [298]. Barangcadoic acid A, rhopaloic acids A, B, C, and an inseparable mixture of rhopaloic acids D and E, Fig.…”

Section: Egfr/ras/raf/mek/mapk Signalingmentioning

confidence: 96%

Mechanism Targeted Discovery of Antitumor Marine Natural Products

Nagle¹,

Zhou²,

Mora³

et al. 2004

Current Medicinal Chemistry

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Antitumor drug discovery programs aim to identify chemical entities for use in the treatment of cancer. Many strategies have been used to achieve this objective. Natural products have always played a major role in anticancer medicine and the unique metabolites produced by marine organisms have increasingly become major players in antitumor drug discovery. Rapid advances have occurred in the understanding of tumor biology and molecular medicine. New insights into mechanisms responsible for neoplastic disease are significantly changing the general philosophical approach towards cancer treatment. Recently identified molecular targets have created exciting new means for disrupting tumor-specific cell signaling, cell division, energy metabolism, gene expression, drug resistance, and blood supply. Such tumor-specific treatments could someday decrease our reliance on traditional cytotoxicity-based chemotherapy and provide new less toxic treatment options with significantly fewer side effects. Novel molecular targets and state-of-the-art molecular mechanism-based screening methods have revitalized antitumor research and these changes are becoming an ever-increasing component of modern antitumor marine natural products research. This review describes marine natural products identified using tumor-specific mechanism-based assays for regulators of angiogenesis, apoptosis, cell cycle, macromolecule synthesis, mitochondrial respiration, mitosis, multidrug efflux, and signal transduction. Special emphasis is placed on natural products directly discovered using molecular mechanism-based screening.

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Novel sesterterpenoid and norsesterterpenoid RCE-protease inhibitors isolated from the marine sponge Hippospongia sp.

Cited by 36 publications

References 8 publications

Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.

Cytotoxic Sesterterpenoids from a Sponge Hippospongia sp.

Marine natural products

Mechanism Targeted Discovery of Antitumor Marine Natural Products

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