Novel skeletal rearrangements of a diterpene derived from deltaline

Tang, Pei; Chen, Qifeng; Chen, Qiao‐Hong; Jian, Xi-Xian; Wang, Feng‐Peng

doi:10.1016/j.tet.2012.05.058

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Cited by 3 publications

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Generating Skeletal Diversity from the C₁₉‐Diterpenoid Alkaloid Deltaline: A Ring‐Distortion Approach

Chen

Wang

Liu

2015

Chemistry A European J

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The development of new drugs calls for large collections of diverse molecules with considerable complexity. Ring distortion of natural products provides an efficient and facile approach to access new architectures with intriguing biological activities, by harnessing their inherent complexity. In this study, such a strategy has been explored on an abundant C19 -diterpenoid alkaloid, deltaline, enabling the synthesis of 32 new derivatives bearing a broad spectrum of unique scaffolds. Extensive spectroscopic studies including X-ray crystallographic analyses strongly supported the structures of the obtained novel skeletons, which present comparable opportunities with the great contributions made by nature for discovery of new lead compounds.

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Generating Skeletal Diversity from the C₁₉‐Diterpenoid Alkaloid Deltaline: A Ring‐Distortion Approach

Chen

Wang

Liu

2015

Chemistry A European J

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The diterpenoid alkaloids

Liu

Qin

et al. 2022

The Alkaloids: Chemistry and Biology

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Novel analogues of diterpenoid alkaloids from ring distortion of talatisamine, a potassium ion channel blocker

et al. 2016

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Novel skeletal rearrangements of a diterpene derived from deltaline

Cited by 3 publications

References 8 publications

Generating Skeletal Diversity from the C₁₉‐Diterpenoid Alkaloid Deltaline: A Ring‐Distortion Approach

Generating Skeletal Diversity from the C₁₉‐Diterpenoid Alkaloid Deltaline: A Ring‐Distortion Approach

The diterpenoid alkaloids

Novel analogues of diterpenoid alkaloids from ring distortion of talatisamine, a potassium ion channel blocker

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Novel skeletal rearrangements of a diterpene derived from deltaline

Cited by 3 publications

References 8 publications

Generating Skeletal Diversity from the C19‐Diterpenoid Alkaloid Deltaline: A Ring‐Distortion Approach

Generating Skeletal Diversity from the C19‐Diterpenoid Alkaloid Deltaline: A Ring‐Distortion Approach

The diterpenoid alkaloids

Novel analogues of diterpenoid alkaloids from ring distortion of talatisamine, a potassium ion channel blocker

Contact Info

Product

Resources

About

Generating Skeletal Diversity from the C₁₉‐Diterpenoid Alkaloid Deltaline: A Ring‐Distortion Approach

Generating Skeletal Diversity from the C₁₉‐Diterpenoid Alkaloid Deltaline: A Ring‐Distortion Approach