Novel SNPs of butyrophilin (BTN1A1) and milk fat globule epidermal growth factor (EGF) 8 (MFG-E8) are associated with milk traits in dairy goat

Qu, Yujiao; Li, Yanli; Ma, Li-na; Sweeney, Sandra; Lan, Xianyong; Chen, Zhongqi; Li, Zhuanjian; Lei, Chuzhao; Chen, Hong

doi:10.1007/s11033-010-0118-y

Cited by 21 publications

(14 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They were in the 5 0 -Untranslated Region (5 0 -UTR), the fourth intron, the seventh exon, the seventh intron. Among these SNP, the g.14892 T > C located in the seventh exon of the goat lactadherin gene was found to be significantly associated with the milk fat yield in the Guanzhong dairy breed (Qu et al, 2011). This is the demonstration of a relationship between lactadherin gene expression and milk fat secretion process.…”

Section: Biological Activities Of Lactadherin In the Mammary Gland Anmentioning

confidence: 82%

“…A recent study (Qu et al, 2011) investigated variations in the MFG-E8 gene and its associations with growth traits and milk performance in the goat species (Capra hircus taxon, Guanzhong dairy breed). Interestingly, the authors identified four single nucleotide polymorphisms (SNPs) in the goat MFG-E8 gene.…”

Section: Biological Activities Of Lactadherin In the Mammary Gland Anmentioning

confidence: 99%

See 1 more Smart Citation

Inter-species comparison of milk fat globule membrane proteins highlights the molecular diversity of lactadherin

Cebo¹,

Martin²

2012

International Dairy Journal

View full text Add to dashboard Cite

Chantier qualité GAFat is present in milk as droplets of triacylglycerols surrounded by a complex membrane derived from the mammary epithelial cell called the milk fat globule membrane (MFGM). In-depth proteomic studies have been published for bovine MFGM proteins. However, to date, only sparse studies exist on MFGM proteins from non-cow milk. We have therefore characterized MFGM proteins in goat, sheep, horse and camel milk and we have highlighted prominent differences across species, especially for lactadherin, a major protein of the milk fat globule membrane. Indeed, lactadherin from goat and sheep milk appears as a single polypeptide chain in 10% sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDSPAGE), whereas two and four polypeptide chains are respectively identified for lactadherin from camel and horse milk. Implications of the findings, especially with regard to bioactive properties of milk are discussed

show abstract

Section: Biological Activities Of Lactadherin In the Mammary Gland Anmentioning

confidence: 82%

Section: Biological Activities Of Lactadherin In the Mammary Gland Anmentioning

confidence: 99%

Inter-species comparison of milk fat globule membrane proteins highlights the molecular diversity of lactadherin

Cebo¹,

Martin²

2012

International Dairy Journal

View full text Add to dashboard Cite

show abstract

“…7), which is highly expressed in the secretory epithelium of the mammary gland during lactation, and is essential for the regu- lated secretion of milk lipid droplets (35). Previous experiments have shown that certain polymorphisms in BTN1A1 significantly increase the fat content of milk in cattle and goats, whereas its deletion has been found to greatly impact the survival and weaning weight of mice (35,36). We hypothesize that mutations (possibly noncoding) leading to greater expression of this gene or activity of its protein product might result in a higher fat content in PB milk.…”

Section: Adaptation Of Pbs To Arctic Environment: Potential Signals Omentioning

confidence: 99%

Polar and brown bear genomes reveal ancient admixture and demographic footprints of past climate change

Miller

Schuster

Welch

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

329

375

View full text Add to dashboard Cite

Polar bears (PBs) are superbly adapted to the extreme Arctic environment and have become emblematic of the threat to biodiversity from global climate change. Their divergence from the lower-latitude brown bear provides a textbook example of rapid evolution of distinct phenotypes. However, limited mitochondrial and nuclear DNA evidence conflicts in the timing of PB origin as well as placement of the species within versus sister to the brown bear lineage. We gathered extensive genomic sequence data from contemporary polar, brown, and American black bear samples, in addition to a 130,000-to 110,000-y old PB, to examine this problem from a genome-wide perspective. Nuclear DNA markers reflect a species tree consistent with expectation, showing polar and brown bears to be sister species. However, for the enigmatic brown bears native to Alaska's Alexander Archipelago, we estimate that not only their mitochondrial genome, but also 5-10% of their nuclear genome, is most closely related to PBs, indicating ancient admixture between the two species. Explicit admixture analyses are consistent with ancient splits among PBs, brown bears and black bears that were later followed by occasional admixture. We also provide paleodemographic estimates that suggest bear evolution has tracked key climate events, and that PB in particular experienced a prolonged and dramatic decline in its effective population size during the last ca. 500,000 years. We demonstrate that brown bears and PBs have had sufficiently independent evolutionary histories over the last 4-5 million years to leave imprints in the PB nuclear genome that likely are associated with ecological adaptation to the Arctic environment.demographic history | hybridization | mammalian genomics | phylogenetics G enome-scale studies of speciation and admixture have become essential tools in evolutionary analyses of recently diverged lineages. For example, paradigm-shifting genomic research on archaic and anatomically modern humans has identified critical gene flow events during hominin history (1, 2). However, aside from several analyses of domesticated species and their wild relatives (e.g., ref.3), studies that use whole-genome sequencing to investigate admixture in wildlife populations are only now beginning to emerge.The bear family (Ursidae, Mammalia) represents an excellent, largely untapped model for investigating complex speciation and rapid evolution of distinct phenotypes. Although polar bears (PBs; Ursus maritimus) and brown bears (Ursus arctos) are considered separate species, analyses of fossil evidence and mitochondrial sequence data have indicated a recent divergence of PBs from within brown bears (surveyed in ref. 4). For example, phylogenetic analyses of complete mitochondrial genomes, including from a unique 130,000-to 110,000-y-old PB jawbone from Svalbard, Norway, confirmed a particularly close relationship between PB and a genetically isolated population of brown bears from the Admiralty, Baranof, and Chichagof islands in Alaska's Alexander Archipelago (hereaf...

show abstract

“…These genes belong to different functional categories related with lipogenesis (ACACA, DGAT1, DGAT2, ME1, and SCD); lipolysis (LPL and LIPE); milk fat globule membrane proteins (BTN1A1 and MFGE); hormone signaling (GH and PRLR); and transcription factors regulating gene expression (PITX2, POUF1, and STAT5), amongst others [45][46][47][48][49][50][51][52][53][54][55][56][57][58][59]. Although the main phenotype analysed in these reports is milk fat content, in some of them the genetic analysis of milk fatty acid composition has been undertaken (e.g., [53,55,58,59]).…”

Section: Candidate Genes For Dairy Traitsmentioning

confidence: 99%

The Application of Genomic Technologies to Investigate the Inheritance of Economically Important Traits in Goats

Amills

2014

Advances in Biology

View full text Add to dashboard Cite

Goat genomics has evolved at a low pace because of a lack of molecular tools and sufficient investment. Whilst thousands and hundreds of quantitative trait loci (QTL) have been identified in cattle and sheep, respectively, about nine genome scans have been performed in goats dealing with traits as conformation, growth, fiber quality, resistance to nematodes, and milk yield and composition. In contrast, a great effort has been devoted to the characterization of candidate genes and their association with milk, meat, and reproduction phenotypes. In this regard, causal mutations have been identified in the S1 -casein gene that has a strong effect on milk composition and the PIS locus that is linked to intersexuality and polledness. In recent times, the development of massive parallel sequencing technologies has allowed to build a reference genome for goats as well as to monitor the expression of mRNAs and microRNAs in a broad array of tissues and experimental conditions. Besides, the recent design of a 52K SNP chip is expected to have a broad impact in the analysis of the genetic architecture of traits of economic interest as well as in the study of the population structure of goats at a worldwide scale.

show abstract

Novel SNPs of butyrophilin (BTN1A1) and milk fat globule epidermal growth factor (EGF) 8 (MFG-E8) are associated with milk traits in dairy goat

Cited by 21 publications

References 35 publications

Inter-species comparison of milk fat globule membrane proteins highlights the molecular diversity of lactadherin

Inter-species comparison of milk fat globule membrane proteins highlights the molecular diversity of lactadherin

Polar and brown bear genomes reveal ancient admixture and demographic footprints of past climate change

The Application of Genomic Technologies to Investigate the Inheritance of Economically Important Traits in Goats

Contact Info

Product

Resources

About