Novel Strategies for the Discovery of Plant-Derived Anticancer Agents

Cordell, Geoffrey A.; Farnsworth, Norman R.; Beecher, Christopher W.W.; Soejarto, Djaja D.; Kinghorn, A. Douglas; Pezzuto, John M.; Wall, Monroe E.; Wani, M. C.; Cobb, Ronald R.; O’Neill, Melanie J.; Tait, R. Murray; Harris, T. J. R.

doi:10.1007/978-1-4615-2610-0_4

Cited by 9 publications

(7 citation statements)

References 13 publications

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“…One such strand is the examination of traditional medicines for antimicrobial producing bacteria or antimicrobials themselves. This follows from successful generation of lead compounds in the field of cancer [9].…”

Section: Discussionmentioning

confidence: 99%

“…One of the inspirations for research into traditional medicine may have come from Geoffrey Cordell, who devised a series of systematic searches of plant metabolites for anticancer medicines. This included an ethnomedical approach, which evaluated and highlighted the importance of written or historical evidence from traditional medicinal practice [9]. Additionally, there have been a number of reports of epiphytic and endophytic species of Streptomyces associated with traditional medicine plants from many continents [10,11].…”

Section: Introductionmentioning

confidence: 99%

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The Isolation of a Novel Streptomyces sp. CJ13 from a Traditional Irish Folk Medicine Alkaline Grassland Soil that Inhibits Multiresistant Pathogens and Yeasts

et al. 2020

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The World Health Organization recently stated that new sources of antibiotics are urgently required to stem the global spread of antibiotic resistance, especially in multiresistant Gram-negative bacteria. Although it was thought that many of the original sources of antibiotics were exhausted, innovative research has revealed promising new sources of antibiotic discovery in traditional medicine associated with Streptomyces. In this work we investigated the potential of a specific limestone grassland soil, associated with Irish folk medicine, as a new source of antimicrobial discovery. Using selective enrichment and isolation techniques on a limestone grassland soil sample obtained from Boho, West Fermanagh, we isolated Streptomyces sp. CJ13. This bacterium inhibited the growth of a broad range of pathogens in vitro including Gram positive Staphylococcus aureus (MRSA 43300) and Gram negative multiresistant Pseudomonas aeruginosa (PA01), as well as the anaerobic bacteria Propionibacterium acnes and the yeast Starmerella bombicola. Genome sequencing and phylogenetic analysis revealed Streptomyces sp. CJ13 to be closely related to an unclassified Streptomyces sp. MJM1172, Streptomyces sp. Mg1 and two species known as Streptomyces sp. ICC1 and ICC4 from a karst region in British Columbia. The closest type species to Streptomyces sp. CJ13 was Streptomyces lavendulae subspecies lavendulae. Analysis of Streptomyces sp. CJ13 whole genome sequence using the secondary metabolite prediction tool antiSMASH revealed similarities to several antibiotic gene synthesis clusters including salinichelin, mediomycin A, weishanmycin, combamide, heat stable antifungal factor and SAL-2242. These results demonstrate the potential of this alkaline grassland soil as a new resource for the discovery of a broad range of antimicrobial compounds including those effective against multiresistant Gram negative bacteria.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Isolation of a Novel Streptomyces sp. CJ13 from a Traditional Irish Folk Medicine Alkaline Grassland Soil that Inhibits Multiresistant Pathogens and Yeasts

et al. 2020

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“…One of the inspirations for research into traditional medicine may have come from Geoffrey Cordell, who devised a series of systematic searches of plant metabolites for anticancer medicines. This included an ethno-medical approach, which evaluated written or historical evidence from traditional medicinal practice [26]. Since then, many Streptomyces have been isolated from traditional plant medicines, especially in areas of low nutrient availability or extreme physiological conditions [27,28].…”

Section: Streptomyces From Traditional Medicinal Plantsmentioning

confidence: 99%

Streptomyces from traditional medicine: sources of new innovations in antibiotic discovery

Quinn

Banat

Abdelhameed

et al. 2020

Journal of Medical Microbiology

166

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Given the increased reporting of multi-resistant bacteria and the shortage of newly approved medicines, researchers have been looking towards extreme and unusual environments as a new source of antibiotics. Streptomyces currently provides many of the world’s clinical antibiotics, so it comes as no surprise that these bacteria have recently been isolated from traditional medicine. Given the wide array of traditional medicines, it is hoped that these discoveries can provide the much sought after core structure diversity that will be required of a new generation of antibiotics. This review discusses the contribution of Streptomyces to antibiotics and the potential of newly discovered species in traditional medicine. We also explore how knowledge of traditional medicines can aid current initiatives in sourcing new and chemically diverse antibiotics.

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“…From ancient times is well understood that, natural products have a key role in the discovery in development of many antibiotics (Newman and Cragg, 2007). One of the best approach to the discovery of new antimicrobial agents natural sources has been to use folklore or historical records to guide the collection of samples or a good research work on the soil of that area (Cordell et al, 1994).…”

Section: Antibioticsmentioning

confidence: 99%

Isolation of Soil Bacteria for Potential Production of Antibiotics and their Inhibitory Effect on Growth of Pathogens

Biradar¹,

Ashwini²,

Lachuriye³

et al. 2016

Int.J.Curr.Microbiol.App.Sci

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Novel Strategies for the Discovery of Plant-Derived Anticancer Agents

Cited by 9 publications

References 13 publications

The Isolation of a Novel Streptomyces sp. CJ13 from a Traditional Irish Folk Medicine Alkaline Grassland Soil that Inhibits Multiresistant Pathogens and Yeasts

The Isolation of a Novel Streptomyces sp. CJ13 from a Traditional Irish Folk Medicine Alkaline Grassland Soil that Inhibits Multiresistant Pathogens and Yeasts

Streptomyces from traditional medicine: sources of new innovations in antibiotic discovery

Isolation of Soil Bacteria for Potential Production of Antibiotics and their Inhibitory Effect on Growth of Pathogens

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