Novel Synthesis of gem‐Dichloroaziridines from Imines via the KF/Al₂O₃‐Promoted Generation of Dichlorocarbene from Chloroform.

Abstract

The KF/Al2O3-promoted reaction of in situ generated dichlorocarbene with imines (I) and (IV) is tolerant to various functional groups like cyano, nitro groups or double bonds. In the case of imines (IV), the reaction does not stop at the stage of dichloroaziridines [cf. (III)] but gives the corresponding hydrolysis products (V). -(MIHARA, M.; ISHINO*, Y.; MINAKATA, S.; KOMATSU, M.; J. Org. Chem. 70 (2005) 13, 5320-5322; Osaka Munic. Tech. Res. Inst., Joto, Osaka 536, Japan; Eng.) -Mischke 45-125

Síntese de gem-dicloroaziridinas empregando KF/Al2O3

“…As metodologias utilizadas na preparação das amidas foram as mesmas propostas pelas literaturas 4,21 …”

“…Embora a metodologia empregada para amidas método 2 tenha sido a mesma utilizada pela literatura 4 , as reações não ocorreram.…”