Novel Therapeutic Approach for the Treatment of Periodontitis by Curcumin

Abstract

Locally delivered 1% curcumin gel was more effective in inhibiting the growth of oral bacteria when used as an adjunct to SRP in the treatment of chronic periodontitis.

Antibacterial activity of curcumin (turmeric) against periopathogens - An in vitro evaluation

“…Bhatia et al [30] proved the bactericidal activity of curcumin against P. gingivalis and P. intermedia.…”

“…Bhatia et al [30] examined that the patients with 1% curcumin gel along with scaling and root planning showed improvements in clinical parameters and reductions in the count of periodontopathic bacteria and were seen after 6 months, comparing with control sites receiving scaling and root planing only. Curcumin was used with scaling and root planing in the treatment of gingivitis and chronic periodontitis.…”

Determining whether curcumin degradation/condensation is actually bioactivation (Review)

“…Guimarães et al also observed the lack of inhibition of bone resorption in an experimental model of lipopolysacharide (LPS)-induced periodontal disease (76), which is surprising, keeping in mind that curcumin was shown to significantly inhibit Porphyromonas gingivalis LPS-induced TNF-α and IL-1β production (80). Curcumin has also exhibited exhibited bactericidal activity against Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum and capnocytophaga at a minimal inhibitory concentration (MIC) of 1 mg/ml by the local application into periodontal pockets in humans (81). The results of the benzoyl-DL-arginine-naphthylamide (BANA) test, which verifyied the presence of Tannerella forsythia, Treponema denticola, Porphyromonas gingivalis and capnocytophaga species, was similar for 1% curcumin solution and 0.2% chlorhexidine gluconate in subgingival irrigation.…”

Oral Mucoadhesive Buccal Film of Ciprofloxacin for Periodontitis: Preparation and Characterization

“…Studies have reported the anti-periodontitis activity of films or other localised oral mucosal or gingival drug delivery systems [18][19][20][21][22][23]. Many studies have reported on the potential of novel ciprofloxacin delivery devices in the treatment of periodontitis [24][25][26][27].…”