Novel therapeutic approaches targeting oxidative stress in neurodegenerative diseases

Yadav, Somu; Kumar, Akshay; Deepika,; Maurya, Pawan Kumar

doi:10.1016/b978-0-323-90905-1.00005-5

Novel Therapeutic Approaches Targeting Oxidative Stress 2022

DOI: 10.1016/b978-0-323-90905-1.00005-5

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Novel therapeutic approaches targeting oxidative stress in neurodegenerative diseases

Somu Yadav

Akshay Kumar

Deepika Deepika

et al.

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Cited by 3 publications

References 66 publications

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The Role of Oxidative Stress in Trisomy 21 Phenotype

Buczyńska,

Sidorkiewicz,

Krętowski

et al. 2023

Cell Mol Neurobiol

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Extensive research has been conducted to gain a deeper understanding of the deregulated metabolic pathways in the development of trisomy 21 (T21) or Down syndrome. This research has shed light on the hypothesis that oxidative stress plays a significant role in the manifestation of the T21 phenotype. Although in vivo studies have shown promising results in mitigating the detrimental effects of oxidative stress, there is currently a lack of introduced antioxidant treatment options targeting cognitive impairments associated with T21. To address this gap, a comprehensive literature review was conducted to provide an updated overview of the involvement of oxidative stress in T21. The review aimed to summarize the insights into the pathogenesis of the Down syndrome phenotype and present the findings of recent innovative research that focuses on improving cognitive function in T21 through various antioxidant interventions. By examining the existing literature, this research seeks to provide a holistic understanding of the role oxidative stress plays in the development of T21 and to explore novel approaches that target multiple aspects of antioxidant intervention to improve cognitive function in individuals with Down syndrome. Graphical Abstract The guides -base systematic review process (Hutton et al. 2015).

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The Role of Oxidative Stress in Trisomy 21 Phenotype

Buczyńska,

Sidorkiewicz,

Krętowski

et al. 2023

Cell Mol Neurobiol

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Liposome-Encapsulated Curcumin Offers Sustained Release of Curcumin to Ameliorates the Oxidative Stress Biomarkers of Red Blood Cells During Aging

Kumar,

Bhagat,

Moar

et al. 2024

BioNanoSci.

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Phytochemical screening and anti-inflammatory activities of different fractions from Citrullus lanatus leaves: A comprehensive study

Talabi,

Adeyemi,

Talabi

et al. 2024

Shodh Sari

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Inflammation, a protective immune response, can contribute to maintaining homeostasis but can also cause harm when chronic or excessive. Citrullus lanatus has been suggested to possess antioxidant and anti-inflammatory activities that may aid in preventing and treating oxidative stress and inflammation. The main objective of this study was to evaluate the levels of phytochemicals, as well as the antioxidant and anti-inflammatory activities of Citrullus lanatus leaves extract. The ethyl acetate, hexane, butanol fraction and aqueous methanol extract were subjected to various standard quantitative phytochemical analysis, while the hexane fraction and aqueous methanol extract were subjected to standard in vitro anti-inflammatory assays. Spectrophotometric and gravimetric methods were used in this study. The in vitro anti-denaturation (stabilization) assay was used for detecting a wide range of antioxidant compounds. The ethyl acetate fraction had the highest flavonoid and polyphenol levels, followed by hexane, butanol, and aqueous methanol extract, respectively. Quantitative phytochemical analysis showed the levels of flavonoids, polyphenols, tannins, alkaloids and saponins present in the different fractions of C. lanatus. The human erythrocyte membrane stabilization assay showed that extracts were able to stabilize human red blood cell membrane against hypotonic-induced hemolysis in five different samples. The extract of Citrullus lanatus was found to have the highest antioxidant activity. This study has shown that the leaves of Citrullus lanatus can be used in ethnomedicine for the prevention and treatment of ailments caused by oxidative stress and inflammation-related diseases.

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Novel therapeutic approaches targeting oxidative stress in neurodegenerative diseases

Cited by 3 publications

References 66 publications

The Role of Oxidative Stress in Trisomy 21 Phenotype

The Role of Oxidative Stress in Trisomy 21 Phenotype

Liposome-Encapsulated Curcumin Offers Sustained Release of Curcumin to Ameliorates the Oxidative Stress Biomarkers of Red Blood Cells During Aging

Phytochemical screening and anti-inflammatory activities of different fractions from Citrullus lanatus leaves: A comprehensive study

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