Novel Thermosensitive Polymer-Modified Liposomes as Nano-Carrier of Hydrophobic Antitumor Drugs

Xi, Laishun; Li, Chenglong; Wang, Yuandou; Gong, Yanling; Su, Feng; Li, Suming

doi:10.1016/j.xphs.2020.05.006

Cited by 23 publications

(15 citation statements)

References 37 publications

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“…These acoustic waves are applied as a release mechanism through cavitation which enhances the accumulation of anticancer drugs at the tumor site [101]. Recently, Xi et al, 2020, reported polymer-modified thermoresponsive liposomes (TSL) from utilizing a lipophilic anticancer chemotherapeutic agent for the treatment of cancer from TSLs [102]. This study reflects that this technology could be exploited for delivery of the challenging anticancer drugs using liposomal preparations.…”

Section: Ultrasound-responsive Drug Delivery Systems (Urdds)mentioning

confidence: 97%

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

Rahim

Jan

Khan

et al. 2021

Cancers

137

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The tumor-specific targeting of chemotherapeutic agents for specific necrosis of cancer cells without affecting the normal cells poses a great challenge for researchers and scientists. Though extensive research has been carried out to investigate chemotherapy-based targeted drug delivery, the identification of the most promising strategy capable of bypassing non-specific cytotoxicity is still a major concern. Recent advancements in the arena of onco-targeted therapies have enabled safe and effective tumor-specific localization through stimuli-responsive drug delivery systems. Owing to their promising characteristic features, stimuli-responsive drug delivery platforms have revolutionized the chemotherapy-based treatments with added benefits of enhanced bioavailability and selective cytotoxicity of cancer cells compared to the conventional modalities. The insensitivity of stimuli-responsive drug delivery platforms when exposed to normal cells prevents the release of cytotoxic drugs into the normal cells and therefore alleviates the off-target events associated with chemotherapy. Contrastingly, they showed amplified sensitivity and triggered release of chemotherapeutic payload when internalized into the tumor microenvironment causing maximum cytotoxic responses and the induction of cancer cell necrosis. This review focuses on the physical stimuli-responsive drug delivery systems and chemical stimuli-responsive drug delivery systems for triggered cancer chemotherapy through active and/or passive targeting. Moreover, the review also provided a brief insight into the molecular dynamic simulations associated with stimuli-based tumor targeting.

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Section: Ultrasound-responsive Drug Delivery Systems (Urdds)mentioning

confidence: 97%

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

Rahim

Jan

Khan

et al. 2021

Cancers

137

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“…Smart drug delivery systems using temperature‐responsive polymers are ideal for targeted delivery or controlled drug release. [ 28,29 ] Modification of nanocarriers with PNIPAAm derivatives can alter the LCST, leading to a more flexible nanoparticle tailored to its application, whether the aim is for the prolonged, burst, or sustained release of drugs. [ 29,30 ] Examples of nanocarriers that have been widely studied and well‐established are liposomes, micelles, and polymeric nanoparticles.…”

Section: Pnipaam Applications In Drug Delivery Systemsmentioning

confidence: 99%

Poly(N‐isopropylacrylamide)‐Based Polymers: Recent Overview for the Development of Temperature‐Responsive Drug Delivery and Biomedical Applications

Shaibie

Ramli

Faizal

et al. 2023

Macro Chemistry & Physics

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Temperature is a widely incorporated stimulus in pharmaceutical applications because of its efficiency as a therapeutic medium; thus, substantial evidence on temperature‐responsive polymer applications is reported. Poly(N‐isopropylacrylamide) (PNIPAAm) is a well‐established, temperature‐responsive polymer that exhibits a low critical solution temperature (LCST) at ≈ 32°C, which is close to physiological temperature. Hence, they are widely used in various pharmaceutical applications, such as drug delivery with nanocarriers and thermogels. Varying the LCST for different applications can be achieved by copolymerization with other hydrophobic or hydrophilic molecules, making it a favorable smart polymer. PNIPAAm is reported to enhance drug delivery by incorporation with nanocarriers and to facilitate prolonged drug delivery, thereby avoiding the burst release of drugs in temperature‐responsive hydrogels. The application of PNIPAAm is not limited to drug delivery, and it is also applied in biomedical applications such as chromatography systems and cell culture applications, where its incorporation in cell culture media enhances cell production. The unique and versatile properties of PNIPAAm render it a promising smart polymer for various functional applications. Hence, this review focuses on the diverse applications of PNIPAAm.This article is protected by copyright. All rights reserved

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“…The PTSL showed low cytotoxicity while carrying the drug. They reduced the viability of A549 lung cancer cells ( Xi et al, 2020 ).…”

Section: Liposomes For Delivery Of Therapeutic and Imaging Agentsmentioning

confidence: 99%

Physically stimulus-responsive nanoparticles for therapy and diagnosis

et al. 2022

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Nanoparticles offer numerous advantages in various fields of science, particularly in medicine. Over recent years, the use of nanoparticles in disease diagnosis and treatments has increased dramatically by the development of stimuli-responsive nano-systems, which can respond to internal or external stimuli. In the last 10 years, many preclinical studies were performed on physically triggered nano-systems to develop and optimize stable, precise, and selective therapeutic or diagnostic agents. In this regard, the systems must meet the requirements of efficacy, toxicity, pharmacokinetics, and safety before clinical investigation. Several undesired aspects need to be addressed to successfully translate these physical stimuli-responsive nano-systems, as biomaterials, into clinical practice. These have to be commonly taken into account when developing physically triggered systems; thus, also applicable for nano-systems based on nanomaterials. This review focuses on physically triggered nano-systems (PTNSs), with diagnostic or therapeutic and theranostic applications. Several types of physically triggered nano-systems based on polymeric micelles and hydrogels, mesoporous silica, and magnets are reviewed and discussed in various aspects.

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Novel Thermosensitive Polymer-Modified Liposomes as Nano-Carrier of Hydrophobic Antitumor Drugs

Cited by 23 publications

References 37 publications

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

Recent Advancements in Stimuli Responsive Drug Delivery Platforms for Active and Passive Cancer Targeting

Poly(N‐isopropylacrylamide)‐Based Polymers: Recent Overview for the Development of Temperature‐Responsive Drug Delivery and Biomedical Applications

Physically stimulus-responsive nanoparticles for therapy and diagnosis

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