Novel Thioacetal-Bridged Hollow Mesoporous Organosilica Nanoparticles with ROS-Responsive Biodegradability for Smart Drug Delivery

Abstract

Intelligent, efficient silica nanoparticles for drug delivery system in cancer therapy have a great application potential, but the biodegradability of silica nanoparticles becomes an intractable hindrance. In this work, novel reactive oxygen species (ROS)-responsive hollow mesoporous organosilica nanoparticles (HMONs) coated with polydopamine (PDA) biofilm and amino-terminated methoxy poly(ethylene glycol) (mPEG-NH[Formula: see text] were synthesized and applied in the smart drug delivery system (HMONs@PDA-mPEG) for the delivery of doxorubicin (DOX). The nanostructures and morphologies of nanoparticles were characterized by Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM), N2 adsorption/desorption, dynamic light scattering (DLS) and thermogravimetric analysis. Based on the “chemical homology” mechanism, physiologically active thioacetal-bridged silsesquioxane was molecularly incorporated into the framework of silica nanoparticles to form ROS-responsive HMONs, which was verified by the in vitro degradation experiment. The in vitro drug release profiles showed a synergistically pH-dependent and ROS-responsive drug release effect. MTT assay toward A549 cells demonstrated that drug carriers had a biocompatibility, and DOX-loaded nanoparticles (DNs) presented a concentration-dependent and time-dependent cell growth inhibition effect. In summary, the novel ROS-responsive HMONs@PDA-mPEG had a promising application as a smart drug delivery system in biomedical field.

Synthesis of phenylalanine and leucine dipeptide functionalized silica-based nanoporous material as a safe UV filter for sunscreen

“…1 H and 13 C NMR (400 MHz) spectra were obtained by using a Bruker AC-400 Avance spectrometer at 298 K. All chemical shifts were reported in the standard d notation of parts per million (ppm). The mass spectrum was obtained by using an Agilent 6550 iFunnel Q-TOF.…”

“…Functionalized mesoporous silica has the advantages of excellent physical stability, uniform pores, large specific surface area, and excellent biocompatibility [11][12][13][14][15]. In previous studies, mesoporous silica was used as a physical barrier covering the surface of organic molecules that absorb UV light and inorganic nanoparticles that block UV light to reduce the harmful effects of these ingredients on the skin [16][17][18].…”

Recent advanced development of metal-loaded mesoporous organosilicas as catalytic nanoreactors

“…34 Recently, the ash-nano-precipitation technique was successfully developed as a facile and efficient strategy for the rapid fabrication of morphology-controlled nanosized organosilica particles. 35 Due to their biocompatibility, 36 PMO NPs have been widely used as versatile platforms for the smart delivery of therapeutics, 37 photodynamic therapy of cancer, 38 drug delivery, [39][40][41] chemo-immuno-therapy 42 and oxygen-sensitized radiotherapy. 43 It is very obvious that at present the application of PMO NPs mainly deals with the aspects of biomedicine and biotechnology.…”