Novel treatment of recurrent orbital venolymphatic malformation with sirolimus and rivaroxaban

Purt, Boonkit; Rana, Harkaran S; Whitescarver, Todd D.; Chou, Eva

doi:10.1080/01676830.2021.1929339

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…The successful combination of sirolimus with rivaroxaban for the treatment of a venolymphatic orbital malformation has also been described in a 20-year-old boy. In that case, the combination treatment reduced the size of the lesion and was not associated with thrombotic complications (11) .…”

Section: Discussionmentioning

confidence: 82%

Treatment of orbital lymphatic malformation with oral sirolimus: a case report

Alba‐Linero¹,

Lorente²,

Rachwani-Anil³

et al. 2023

ABO

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It is estimated that lymphatic malformations in children account for 6% of all benign vascular malformations. New medical therapies have been developed for the management of lymphatic orbital disease. The purpose of this article was to describe a clinical case of orbital venolymphatic malformation in a 10-year-old boy, causing proptosis and palpebral edema. The lesion was initially treated with local sclerotherapy. However, the lesion relapsed, and was successfully treated with oral sirolimus. Prospective studies are warranted to determine the appropriate dose and extend the indications of sirolimus in these patients.

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Section: Discussionmentioning

confidence: 82%

Treatment of orbital lymphatic malformation with oral sirolimus: a case report

Alba‐Linero¹,

Lorente²,

Rachwani-Anil³

et al. 2023

ABO

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“…An example of this are orbital malformations with extensive intraconal involvement, in which sclerotherapy is not enough to treat the whole lesion and surgery would not allow the complete resection due to the complex anatomy of tissues adjacent to the lesion. 12,[41][42][43][44]…”

Section: Managementmentioning

confidence: 99%

Update on orbital vascular anomalies in pediatrics: imaging studies and management

et al. 2022

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Orbital vascular anomalies (OVAs) are a heterogeneous group of disorders frequently found in the orbital cone, the periorbital region, or within the orbit itself. OVAs are divided into tumors and malformations. The most frequent clinical presentation is exophthalmos, associated or not with an alteration of the visual axis. They may also cause acute complications, being intralesional bleeding or cellulitis the most frequent, and chronic complications, such as amblyopia and long-term visual acuity impairment.The development of imaging techniques, the use of new drugs, and the implementation of innovative procedures in interventional radiology have resulted in a significant improvement in the diagnostic and therapeutic approaches to these patients, essential to an accurate diagnosis and management.

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“…Un ejemplo de esto son aquellas malformaciones orbitarias con extensión intraconal importante, en las cuales la escleroterapia no es suficiente para tratar toda la lesión y la cirugía no permitiría la resección completa por la compleja anatomía de los tejidos adyacentes a la lesión. 12,[41][42][43][44]…”

Section: Tratamientounclassified

Actualización en anomalías vasculares de la órbita en pediatría: diagnóstico por imágenes y tratamiento

2022

Arch Argent Pediat

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Novel treatment of recurrent orbital venolymphatic malformation with sirolimus and rivaroxaban

Cited by 7 publications

References 21 publications

Treatment of orbital lymphatic malformation with oral sirolimus: a case report

Treatment of orbital lymphatic malformation with oral sirolimus: a case report

Update on orbital vascular anomalies in pediatrics: imaging studies and management

Actualización en anomalías vasculares de la órbita en pediatría: diagnóstico por imágenes y tratamiento

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