Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production

Fu, Qiang; Yang, Min; Ma, Yu; Jiang, Chen; Yuan, Hai-Mei

doi:10.1016/s1875-5364(18)30039-6

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…Scientists have shown that triterpenes exist in R. stricta via cheminformatics studies that they performed to determine the bioactive molecules responsible for their therapeutic potential [ 35 ]. Scholars have revealed that triterpenes have various medicinal uses due to their antitumor activities [ 36 ], inhibitory effect on nitric oxide (NO) production [ 37 ], anti-inflammatory activities [ 38 ], and antineoplastic activities [ 39 ]. Although R. stricta has high therapeutic potential, its phthalic acid content has provoked discussions about the adverse effect of this bioactive compound [ 40 , 41 ].…”

Section: Resultsmentioning

confidence: 99%

GC-MS Analysis of Bioactive Compounds Extracted from Plant Rhazya stricta Using Various Solvents

Baeshen

Almulaiky

Afifi

et al. 2023

Plants

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Worldwide, human beings have traditionally employed many folkloric herbal resources as complementary and alternative remedies, and these remedies have played a pivotal role in modern medicines for many decades, as scientists have used them to develop drugs. We studied the effects of employing solvents with varying polarity on the yields of phytochemical components extracted from the plant Rhazya stricta. We used chloroform–methanol (1:1), methanol, ethanol, diethyl ether, and ethyl acetate as extraction solvents. The results showed that the efficiencies of the solvents at extracting phytochemical compounds were in this order: chloroform–methanol < ethanol < methanol < diethyl ether < ethyl acetate extract. The chloroform–methanol extract produced the highest concentration of phenolic and flavonoid contents among the five solvents tested (13.3 mg GAE/g DM and 5.43 CE/g DM). The yields of the extracted phytochemical compounds ranged from 47.55 to 6.05%. The results revealed that the properties of the extraction solvents considerably impacted the extraction yield and the phytochemical components of the R. stricta extract. Furthermore, compared with the other solvents, the chloroform–methanol extraction led to the highest yield (47.55%) and to more phytochemical substances being extracted. The aim of this study is to investigate the phytochemical compounds extracted from R. stricta with different solvents that have different polarities.

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Section: Resultsmentioning

confidence: 99%

GC-MS Analysis of Bioactive Compounds Extracted from Plant Rhazya stricta Using Various Solvents

Baeshen

Almulaiky

Afifi

et al. 2023

Plants

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show abstract

“…Hederagenin, a major component of CMR, is well known to attenuate inflammatory response [13]. Furthermore, triterpene saponins derived from Clematis mandshurica possess inhibitory activities on nitrous oxide (NO) production [38]. On the other hand, caffeic acid isolated from leaf of Erigeron annuus confers neuroprotective and antioxidant effects [39].…”

Section: Discussionmentioning

confidence: 99%

YES-10, A Combination of Extracts from Clematis mandshurica RUPR. and Erigeron annuus (L.) PERS., Prevents Ischemic Brain Injury in A Gerbil Model of Transient Forebrain Ischemia

Lee

Park

Kim

et al. 2020

Plants

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Clematis mandshurica RUPR. (CMR) and Erigeron annuus (L.) PERS. (EALP) have pharmacological effects including anti-inflammatory activity and been used in traditional medicines in Asia. However, neuroprotective effects of CMR and/or EALP extracts against brain ischemic insults have never been addressed. Thus, the aim of this study was to examine neuroprotective effects of YES-10, a combination of extracts from CMR and EALP (combination ratio, 1:1), in the hippocampus following ischemia/reperfusion in gerbils. Protection of neurons was investigated by cresyl violet staining, fluoro-jade B histofluorescence staining and immunohistochemistry for neuronal nuclei. In addition, attenuation of gliosis was studied by immunohistochemistry for astrocytic and microglial markers. Treatments with 50 or 100 mg/kg YES-10 failed to protect neurons in the hippocampus after ischemia/reperfusion injury. However, administration of 200 mg/kg YES-10 protected neurons from ischemia/reperfusion injury and attenuated reactive gliosis. These findings strongly suggest that a combination of extracts from CMR and EALP can be used as a prevention approach/drug against brain ischemic damage.

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Platycosides P and Q, two new triterpene saponins from Platycodon grandiflorum

Qiu

Xiao

Liu

et al. 2018

Journal of Asian Natural Products Research

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The EtOH extract of the roots of Platycodon grandiflorum afforded two new triterpene saponins platycoside P (1) and platycoside Q (2). Their structures were elucidated based on spectroscopic means and hydrolysis products. These compounds were evaluated for inhibitory activity against LPS-induced TNF-α production in RAW 246.7 macrophages. Compounds 1 and 2 showed inhibitory activity with the inhibition ratios (%) of 38.6 and 44.1 at 50 μM, respectively.

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Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production

Cited by 6 publications

References 12 publications

GC-MS Analysis of Bioactive Compounds Extracted from Plant Rhazya stricta Using Various Solvents

GC-MS Analysis of Bioactive Compounds Extracted from Plant Rhazya stricta Using Various Solvents

YES-10, A Combination of Extracts from Clematis mandshurica RUPR. and Erigeron annuus (L.) PERS., Prevents Ischemic Brain Injury in A Gerbil Model of Transient Forebrain Ischemia

Platycosides P and Q, two new triterpene saponins from Platycodon grandiflorum

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