Novel tumor-targeted RGD peptide–camptothecin conjugates: Synthesis and biological evaluation

Pozzo, Alma Dal; Ni, Minghong; Esposito, Emiliano; Dallavalle, Sabrina; Musso, Loana; Bargiotti, Alberto; Pisano, Claudio; Vesci, Loredana; Bucci, Federica; Castorina, Massimo; Foderà, Rosanna; Giannini, Giuseppe; Aulicino, Concetta; Penco, Sergio

doi:10.1016/j.bmc.2009.11.019

Cited by 53 publications

(41 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the last decade, various biosystems and antitumor agents have been developed so as to act as tumor-targeting drugs containing tumor recognition active sites and a cytotoxic warhead connected directly or with a suitable linker to form conjugates. [36][37][38][39][40] Lung cancer is the leading cause of cancer-related deaths, and its incidence continues to rise worldwide. 41 Generally this cancer classified in two major histological types: roughly 80% are non-small-cell lung cancers (NSCLCs), comprising adenocarcinoma, large-cell carcinoma, and squamous cell carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Bioengineering functional copolymers. XIV. Synthesis and interaction of poly(N-isopropylacrylamide-co-3,4-dihydro-2H-pyran-alt-maleic anhydride)s with SCLC cancer cells

Türk

Rzayev

Khalilova³

2010

Bioorganic & Medicinal Chemistry

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Bioengineering functional copolymers. XIV. Synthesis and interaction of poly(N-isopropylacrylamide-co-3,4-dihydro-2H-pyran-alt-maleic anhydride)s with SCLC cancer cells

Türk

Rzayev

Khalilova³

2010

Bioorganic & Medicinal Chemistry

View full text Add to dashboard Cite

“…Linear as well as cyclic RGD peptide antagonist of α v -integrins have been synthesized, labeled and evaluated for tumor targeting in various animal models, leading to encouraging results. [15][16][17] We herein report the new method for synthesis of DOTA-peptide which is chemical modification of precursor of DOTA bound α V β 3 tripeptide RGD on solid support. The method of synthesis mentioned in this paper is the new way for synthesis of DOTA-peptide.…”

Section: Solid Phase Synthesis Radiolabeling and Biological Evaluatimentioning

confidence: 99%

Solid phase synthesis, radiolabeling and biological evaluation of a^99mTc-labeled α_Vβ₃tripeptide (RGD) conjugated to DOTA as a tumor imaging agent

Varshney

Hazari²,

Uppal³

et al. 2011

Cancer Biology & Therapy

View full text Add to dashboard Cite

“…The results point out the potential challenges in optimizing the physiochemical properties of peptide-drug conjugates. 74 Overall, these results suggest that RGD peptides have promise in delivering drugs to cells with upregulated integrin receptors.…”

Section: Drug-rgd Peptide Conjugatesmentioning

confidence: 96%

Peptide‐mediated targeted drug delivery

Majumdar

Siahaan

2010

Medicinal Research Reviews

132

View full text Add to dashboard Cite

Targeted drug delivery to specific group of cells offers an attractive strategy to minimize the undesirable side effects and achieve the therapeutic effect with a lower dose. Both linear and cyclic peptides have been explored as trafficking moiety due to ease of synthesis, structural simplicity, and low probability of undesirable immunogenicity. Peptides derived from sequence of cell surface proteins, such as intercellular adhesion molecule-1 (ICAM-1), LHRH, Bombesin, and LFA-1, have shown potent binding affinity to the target cell surface receptors. Moreover, peptides derived from ICAM-1 receptor can be internalized by the leukemic T-cells along with the conjugated moiety offering the promise to selectively treat cancers and autoimmune diseases. Systematic analyses have revealed that physicochemical properties of the drug-peptide conjugates and their mechanism of receptor-mediated cellular internalization are important controlling factors for developing a successful targeting system. This review is focused on understanding the factors involved in the development of an effective drug-peptide conjugate with an emphasis on the chemistry and biology of the conjugates. Reported results on several promising drug-peptide conjugates have been critically evaluated. The approaches and results presented here will serve as a guide to systematically approach targeted delivery of cytotoxic drug molecules using peptides for treatment of several diseases.

show abstract

Novel tumor-targeted RGD peptide–camptothecin conjugates: Synthesis and biological evaluation

Cited by 53 publications

References 24 publications

Bioengineering functional copolymers. XIV. Synthesis and interaction of poly(N-isopropylacrylamide-co-3,4-dihydro-2H-pyran-alt-maleic anhydride)s with SCLC cancer cells

Bioengineering functional copolymers. XIV. Synthesis and interaction of poly(N-isopropylacrylamide-co-3,4-dihydro-2H-pyran-alt-maleic anhydride)s with SCLC cancer cells

Solid phase synthesis, radiolabeling and biological evaluation of a^99mTc-labeled α_Vβ₃tripeptide (RGD) conjugated to DOTA as a tumor imaging agent

Peptide‐mediated targeted drug delivery

Contact Info

Product

Resources

About

Novel tumor-targeted RGD peptide–camptothecin conjugates: Synthesis and biological evaluation

Cited by 53 publications

References 24 publications

Bioengineering functional copolymers. XIV. Synthesis and interaction of poly(N-isopropylacrylamide-co-3,4-dihydro-2H-pyran-alt-maleic anhydride)s with SCLC cancer cells

Bioengineering functional copolymers. XIV. Synthesis and interaction of poly(N-isopropylacrylamide-co-3,4-dihydro-2H-pyran-alt-maleic anhydride)s with SCLC cancer cells

Solid phase synthesis, radiolabeling and biological evaluation of a99mTc-labeled αVβ3tripeptide (RGD) conjugated to DOTA as a tumor imaging agent

Peptide‐mediated targeted drug delivery

Contact Info

Product

Resources

About

Solid phase synthesis, radiolabeling and biological evaluation of a^99mTc-labeled α_Vβ₃tripeptide (RGD) conjugated to DOTA as a tumor imaging agent