Novel tumour suppressive protein encoded by circular RNA, circ-SHPRH, in glioblastomas

Begum, Sofina; Yiu, Angela; Stebbing, Justin; Castellano, Leandro

doi:10.1038/s41388-018-0230-3

Cited by 92 publications

(73 citation statements)

References 13 publications

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“…It also stabilizes SHPRH as an E3 ligase by ubiquitinating proliferating cell nuclear antigen. In this manner, it inhibits cell proliferation and tumorigenicity [68,169] (Fig. 1a).…”

Section: Shprh-146aamentioning

confidence: 93%

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

et al. 2020

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Non-coding RNAs do not encode proteins and regulate various oncological processes. They are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics and translation omics have begun to elucidate the roles and modes of action of the functional peptides encoded by ncRNA. Here, recent advances in long non-coding RNA (lncRNA) and circular RNA (circRNA)-encoded small peptides are compiled and synthesized. We introduce both the computational and analytical methods used to forecast prospective ncRNAs encoding oncologically functional oligopeptides. We also present numerous specific lncRNA and circRNA-encoded proteins and their cancer-promoting or cancer-inhibiting molecular mechanisms. This information may expedite the discovery, development, and optimization of novel and efficacious cancer diagnostic, therapeutic, and prognostic protein-based tools derived from non-coding RNAs. The role of ncRNA-encoding functional peptides has promising application perspectives and potential challenges in cancer research. The aim of this review is to provide a theoretical basis and relevant references, which may promote the discovery of more functional peptides encoded by ncRNAs, and further develop novel anticancer therapeutic targets, as well as diagnostic and prognostic cancer markers.

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“…It also stabilizes SHPRH as an E3 ligase by ubiquitinating proliferating cell nuclear antigen. In this manner, it inhibits cell proliferation and tumorigenicity [68,169] (Fig. 1a).…”

Section: Shprh-146aamentioning

confidence: 93%

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

et al. 2020

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“…However, an increasing number of studies have revealed that some circRNAs could be translated into proteins in a cap‐independent manner (Begum et al, ; C. Y. Chen & Sarnow, ; Legnini et al, ; Yang et al, ). In fact, this may be unsurprising since the vast majority of circRNAs are exon derivates and are located in the cytoplasm where translation takes place (Begum et al, ; Pamudurti et al, ; Yang et al, ). Interestingly, scientists have shown that circ‐SHPRH (M. Zhang et al, ) could be translated into a 146aa protein with overlapping genetic codes, similar to viral RNAs.…”

Section: Functionmentioning

confidence: 99%

Intriguing circles: Conflicts and controversies in circular RNA research

2019

WIREs RNA

107

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Circular RNAs (circRNAs) are covalently closed RNA circles without a 5 0 cap or 3 0 tail. Since the landmark discovery of ciRS-7/CDR1as functioning as a miR-7 sponge in 2013, circRNAs have become a hot topic in RNA research. CircRNAs have been found to play active roles in cancer, cardiovascular diseases, neurological disorders, and many other diseases. They can function as microRNA (miRNA) sponges, protein scaffolds, and even translation templates. However, as circRNA research expands, many divergent views have emerged. For example, are most circRNAs competent in serving as miRNA sponges? What kinds of circRNAs are most likely to sponge miRNAs? Apart from sponging miRNAs, what could the functions of most circRNAs be? What are the features of circRNAs that are translatable? Many researchers have claimed that circRNAs are abundant, stable, conserved, and specific molecules, which hold great potential in serving as biomarkers. However, circRNA abundance is variable and some circRNAs are abundant while others are not. In addition, their stability and conservation may vary under different circumstances. Furthermore, it is unclear whether circRNA biogenesis is more likely to be regulated by RNA binding proteins or transcription factors. All of these are open questions that remain to be answered by researchers in this field. Discussing and investigating these questions will advance the understanding of this class of novel molecules and may propel inspiring new ideas for future studies.

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“…An increased patient survival was observed with elevated levels of SHPRH-146aa in glioblastoma patients. 196,197 Collectively, these results showed that circRNA was a group of important regulatory factor and related to the occurrence and progression of glioblastoma. Thus, circRNA could serve as potential and valuable biomarker for diagnosis and treatment for glioblastoma patients in the future.…”

Section: Glioblastomamentioning

confidence: 81%

“…CircRNA containing an ORF could translate a functional protein through driving by Internal Ribosome Entry Site (IRES) elements. 196 For example, circ-SHPRH could produce a 17 kDa protein, the circular form of the SNF2 histone linker PHD RING helicase (SHPRH) gene encoded a novel protein that we termed SHPRH-146aa, which was a tumor suppressor in human glioblastoma. Excessive expressed SHPRH-146aa reduced malignant behavior and tumorigenicity in U251 and U373 glioblastoma cells by protecting SHPRH from degradation through the ubiquitin proteasome.…”

Section: Glioblastomamentioning

confidence: 99%

<p>Biological Roles and Mechanisms of Circular RNA in Human Cancers</p>

Tang

Hann

2020

OTT

137

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Circular RNA (circRNA) is an intriguing class of RNA with covalently closedloop structure and is highly stable and conservative. As new members of the ncRNAs, the function, mechanism, potential diagnostic biomarker, and therapeutic target have raised increased attention. Most circRNAs are presented with characteristics of abundance, stability, conservatism, and often exhibiting tissue/developmental-stage-specific manner. Over 30,000 circRNAs have been identified with their unique structures to maintain stability more easily than linear RNAs. An increased numbers of circRNAs are dysregulated and involved in several biological processes of malignance, such as tumorigenesis, growth, invasion, metastasis, apoptosis, and vascularization. Emerging evidence suggests that circRNAs play important roles by acting as miRNA sponge or protein scaffolding, autophagy regulators, and interacting with RNA-binding protein (RBP), which may potentially serve as a novel promising biomarker for prevention, diagnosis and therapeutic target for treatment of human cancer with great significance either in scientific research or clinic arena. This review introduces concept, major features of circRNAs, and mainly describes the major biological functions and clinical relevance of circRNAs, as well as expressions and regulatory mechanisms in various types of human cancer, including pathogenesis, mode of action, potential target, signaling regulatory pathways, drug resistance, and therapeutic biomarkers. All of which provide evidence for the potential utilities of circRNAs in the diagnosis and treatment of cancer.

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Novel tumour suppressive protein encoded by circular RNA, circ-SHPRH, in glioblastomas

Cited by 92 publications

References 13 publications

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

Intriguing circles: Conflicts and controversies in circular RNA research

<p>Biological Roles and Mechanisms of Circular RNA in Human Cancers</p>

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