Novel Ultrathin Films Based on a Blend of PEG-<i>b</i>-PCL and PLLA and Doped with ZnO Nanoparticles

Vannozzi, Lorenzo; Gouveia, Pedro; Pingue, Pasqualantonio; Canale, Claudio; Ricotti, Leonardo

doi:10.1021/acsami.0c00154

Cited by 34 publications

(15 citation statements)

References 91 publications

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“…Osteoblasts growing on the surface of alkali-sodium-modified specimens showed a significant degree of integration with the scaffold, which is of great importance for the development of implants. Considering that new implant surfaces are developed to improve biological cell responses, guiding the differentiation of mesenchymal stem cells toward osteoblasts and enhancing osseointegration, it is commonly reported in the most recent literature that cell growth is facilitated on rough substrates with diversified topography [3,[91][92][93][94]. Additionally, effective osseointegration is significantly stimulated with increasing surface roughness of implants, inter alia titanium substrates (reviewed in [95]).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Titanate Nanolayers in Terms of Their Physicochemical and Biological Properties

et al. 2021

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The surface modification of titanium substrates and its alloys in order to improve their osseointegration properties is one of widely studied issues related to the design and production of modern orthopedic and dental implants. In this paper, we discuss the results concerning Ti6Al4V substrate surface modification by (a) alkaline treatment with a 7 M NaOH solution, and (b) production of a porous coating (anodic oxidation with the use of potential U = 5 V) and then treating its surface in the abovementioned alkaline solution. We compared the apatite-forming ability of unmodified and surface-modified titanium alloy in simulated body fluid (SBF) for 1–4 weeks. Analysis of the X-ray diffraction patterns of synthesized coatings allowed their structure characterization before and after immersing in SBF. The obtained nanolayers were studied using Raman spectroscopy, diffuse reflectance infrared Fourier transform spectroscopy (DRIFT), and scanning electron microscopy (SEM) images. Elemental analysis was carried out using X-ray energy dispersion spectroscopy (SEM EDX). Wettability and biointegration activity (on the basis of the degree of integration of MG-63 osteoblast-like cells, L929 fibroblasts, and adipose-derived mesenchymal stem cells cultured in vitro on the sample surface) were also evaluated. The obtained results proved that the surfaces of Ti6Al4V and Ti6Al4V covered by TiO2 nanoporous coatings, which were modified by titanate layers, promote apatite formation in the environment of body fluids and possess optimal biointegration properties for fibroblasts and osteoblasts.

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Section: Discussionmentioning

confidence: 99%

Assessment of Titanate Nanolayers in Terms of Their Physicochemical and Biological Properties

et al. 2021

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“…Moreover, additive treatment by biodegradable bioactive nanofilms with a sub-micrometric thickness could improve the implant surface without affecting the primary stability required during its insertion. The nanofilms can promote cell proliferation and differentiation, and play a significant role in the matrix calcification [28].…”

Section: Discussionmentioning

confidence: 99%

Histomorphometric Analysis of Osseointegrated Grade V Titanium Mini Transitional Implants in Edentulous Mandible by Backscattered Scanning Electron Microscopy (BS-SEM)

Beltrán

Weber

Lillo

et al. 2020

Metals

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The purpose of this study is to assess the use of grade V titanium mini transitional implants (MTIs) immediately loaded by a temporary overdenture. For this, a histomorphometric analysis of the bone area fraction occupancy (BAFO) was performed by backscattered scanning electron microscopy (BS-SEM). Four female patients were submitted to surgery in which two MTIs were installed and immediately loaded with a temporary acrylic prosthesis. During the same surgery, two regular diameter implants were placed inside the bone and maintained without mechanical load. After 8 months, the MTIs were extracted using a trephine and processed for ultrastructural bone analysis by BS-SEM, and the regular-diameter implants were loaded with an overdenture device. A total of 243 BAFOs of MTIs were analyzed, of which 94 were mainly filled with cortical bone, while 149 were mainly filled with trabecular bone. Bone tissue analysis considering the total BAFOs with calcified tissues showed 72.13% lamellar bone, 26.04% woven bone, and 1.82% chondroid bone without significant differences between the samples. This study revealed that grade V titanium used in immediately loaded MTI was successfully osseointegrated by a mature and vascularized bone tissue as assessed from the BAFO.

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“…[101][102][103] In addition, GelMA can form functional complexes with various polymers and nanoparticles, thus extending its biological applications. [104,105] Poly-l-lactide (PLLA), the l-type stereoisomer of PLA, is an organic piezoelectric material that has shown great potential and applications in sensing, [106] targeted drug delivery, [107] and regenerative medicine, [108] owing to its flexibility and bioresorbable properties. Nguyen and coworkers developed PLLA polymer-based biodegradable piezoelectric sensors for monitoring biological forces.…”

Section: Bioresorbable Materialsmentioning

confidence: 99%

Electronic Drugs: Spatial and Temporal Medical Treatment of Human Diseases

et al. 2021

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pharmaceutical drug delivery and healthcare systems. E-drugs are biocompatible electronic devices capable of identifying specific biological analytes (e.g., glucose, enzymes, and other biomolecules), [1,2] environmental stimuli (e.g., strain, pressure, and external temperature), and electrophysiological signals (e.g., electrocardiograms (ECG), electromyograms (EMG), and electroencephalography (EEG)) to monitor health status and deliver therapeutic treatments in a controlled manner via wireless prompts. [3][4][5] Owing to their innovative functions and technologies, e-drugs have been widely adopted in pharmaceutical and medical research to monitor and treat chronic diseases, which are still considered difficult to cure. Conventional pharmaceutical treatments or medical procedures for chronic diseases encounter a major obstacle in patient compliance, as they involve regular drug intake or treatments. [6] For example, patients with diabetes are recommended to collect blood samples to measure their glucose levels twice a day. However, the International Diabetes Management Practice Study reported that only 29.7-38.5% of patients with type-2 diabetes in Asia, Eastern Europe, and Latin America self-monitor their glucose levels, which hinders effective management of their condition. [7] As a strategy to improve patients' adherence to drug intake and treatments, electronic devices capable of continuously monitoring biological signal levels and therapeutic response via wireless applications have been demanded by the markets.The fundamental differences between electronics and biological tissues have emerged as a challenge in the development of an advanced generation of e-drugs. For instance, soft biological tissues have a low modulus of elasticity, which is typically less than 100 kPa, and high moisture content. By contrast, conventional electronics are generally made of electronic materials such as metals and silicone, which are stiff, with modulus greater than 80 GPa, dry, and static. [8] This mechanical and physical mismatch between human tissues and electronics causes adverse clinical outcomes. Major consequences include inflammatory responses induced by the micromotion of the implant, during and after implantation, as well as scar tissue and fibrotic encapsulation, which substantially compromises the performance and lifetime of e-drugs. [9,10] Recent advances in diagnostics and medicines emphasize the spatial and temporal aspects of monitoring and treating diseases. However, conventional therapeutics, including oral administration and injection, have difficulties meeting these aspects due to physiological and technological limitations, such as long-term implantation and a narrow therapeutic window. As an innovative approach to overcome these limitations, electronic devices known as electronic drugs (e-drugs) have been developed to monitor real-time body signals and deliver specific treatments to targeted tissues or organs. For example, ingestible and patch-type e-drugs could detect changes in biomarkers at the target s...

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Novel Ultrathin Films Based on a Blend of PEG-b-PCL and PLLA and Doped with ZnO Nanoparticles

Cited by 34 publications

References 91 publications

Assessment of Titanate Nanolayers in Terms of Their Physicochemical and Biological Properties

Assessment of Titanate Nanolayers in Terms of Their Physicochemical and Biological Properties

Histomorphometric Analysis of Osseointegrated Grade V Titanium Mini Transitional Implants in Edentulous Mandible by Backscattered Scanning Electron Microscopy (BS-SEM)

Electronic Drugs: Spatial and Temporal Medical Treatment of Human Diseases

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