Novel vinyl-modified RGD conjugated silica nanoparticles based on photo click chemistry for <i>in vivo</i> prostate cancer targeted fluorescence imaging

Li, Hanrui; Li, Ké; Zeng, Qi; Zeng, Yun; Chen, Dan; Pang, Liaojun; Chen, Xueli

doi:10.1039/c9ra04513a

Cited by 10 publications

(4 citation statements)

References 37 publications

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“…The nanoparticles accumulate in tumor cells and emit fluorescence, allowing for the visualization of tumors. 88 , 89 Theranostic nanoparticles are still under development, but they have the potential to revolutionize cancer diagnosis and treatment by providing more effective and personalized applications. The application of nanocomposites in cancer diagnosis is summarized in Table 1 .…”

Section: Nanocomposites In Cancer Diagnosismentioning

confidence: 99%

The Advancing Role of Nanocomposites in Cancer Diagnosis and Treatment

Andoh,

Ocansey,

Naveed

et al. 2024

IJN

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Section: Nanocomposites In Cancer Diagnosismentioning

confidence: 99%

The Advancing Role of Nanocomposites in Cancer Diagnosis and Treatment

Andoh,

Ocansey,

Naveed

et al. 2024

IJN

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“…This synthetic method offers easy access to regiospecific synthesis of 1,4-disubstituted-1,2,3-triazoles in very high yields. The formed 1,2,3-triazole units possess favorable physicochemical properties and act as stable linker units to couple two pharmacophores to give new bifunctional constructs and therapeutic agents …”

Section: Huisgen 13-dipolar Cycloaddition Reactionmentioning

confidence: 99%

“…The formed 1,2,3-triazole units possess favorable physicochemical properties and act as stable linker units to couple two pharmacophores to give new bifunctional constructs and therapeutic agents. 67 However, click reactions also pose few important limitations, such as the in vivo safety of the copper catalyst and the biocompatibility of 1,2,3-triazoles. Other less serious drawbacks include Cu(I) saturation and unwanted side reactions of alkynes reacting with another alkyne leading to alkyne homocoupling.…”

Section: ■ Types Of Click Reactionsmentioning

confidence: 99%

An Overview of Recent Advances in Biomedical Applications of Click Chemistry

2021

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Cu(I)-catalyzed azide−alkyne cycloaddition (CuAAC) is a modular and bioorthogonal approach that is being adopted for the efficient synthesis of organic and bioorganic compounds. It leads to the selective formation of 1,4-disubstituted 1,2,3-triazole units connecting readily accessible building blocks via a stable and biocompatible linkage. The vast array of the bioconjugation applications of click chemistry has been attributed to its fast reaction kinetics, quantitative yields, minimal byproducts, and high chemospecificity and regioselectivity. These combined advantages make click reactions quite suitable for the lead identification and the development of pharmaceutical agents in the fields of medicinal chemistry and drug discovery. In this review, we have outlined the key aspects, the mechanistic details and merits and demerits of the click reaction. In addition, we have also discussed the recent pharmaceutical applications of click chemistry, ranging from the development of anticancer, antibacterial, and antiviral agents to that of biomedical imaging agents and clinical therapeutics.

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“…For that reason, researchers have focused on identifying specific peptidic sequences that provide specific binding of overexpressed cellular receptors. For instance, functionalizing the surface with the RGD peptide is useful for promoting the internalization of MSNs in cells overexpressing αβ-integrin, such as many cancer cells [128][129][130][131][132] or the tumor endothelium [133]. The CD13 receptor, which is upregulated in glioma cells, can be efficiently targeted using NGR-functionalized MSNs [134,135].…”

Section: Peptidesmentioning

confidence: 99%

Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

Gisbert-Garzarán

Vallet‐Regí

2020

Nanomaterials

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Mesoporous silica nanoparticles have been broadly applied as drug delivery systems owing to their exquisite features, such as excellent textural properties or biocompatibility. However, there are various biological barriers that prevent their proper translation into the clinic, including: (1) lack of selectivity toward tumor tissues, (2) lack of selectivity for tumoral cells and (3) endosomal sequestration of the particles upon internalization. In addition, their open porous structure may lead to premature drug release, consequently affecting healthy tissues and decreasing the efficacy of the treatment. First, this review will provide a comprehensive and systematic overview of the different approximations that have been implemented into mesoporous silica nanoparticles to overcome each of such biological barriers. Afterward, the potential premature and non-specific drug release from these mesoporous nanocarriers will be addressed by introducing the concept of stimuli-responsive gatekeepers, which endow the particles with on-demand and localized drug delivery.

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Novel vinyl-modified RGD conjugated silica nanoparticles based on photo click chemistry for in vivo prostate cancer targeted fluorescence imaging

Abstract: Photo click chemistry has been used to prepare RGD conjugated silica nanoprobe (SiO2@T1-RGDk NPs) that exhibits excellent tumor targeting ability and negligible toxicity which enables them to be used for the diagnosis and treatment of cancer.

Cited by 10 publications

References 37 publications

The Advancing Role of Nanocomposites in Cancer Diagnosis and Treatment

The Advancing Role of Nanocomposites in Cancer Diagnosis and Treatment

An Overview of Recent Advances in Biomedical Applications of Click Chemistry

Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

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