Novelty of Dynamic Process in the Synthesis of Biocompatible Silica Nanotubes by Biomimetic Glycyldodecylamide as a Soft Template

Abstract

A dynamic process in the synthesis of silica nanotubes (SNTs) by utilizing glycyldodecylamide (GDA) as a soft template was thoroughly investigated. The morphological evolution from GDA to SNTs was deeply explored to elucidate the formation mechanism for optimizing the synthesis procedure. Various analytical tools, namely, XRD, FTIR, SEM, TEM, Z-potential, and N adsorption/desorption isotherms, were employed during the synthesis procedure. The interactive structure of GDA was also investigated using TEM-EDX as a function of aging time. These studies revealed the stepwise morphology of nanograin, nanofiber, curved plate, and nanotube in the ethanol/water solution when aged at room temperature. The supramolecular GDA molded the vesicle type nanostructure which was surrounded by silica and facilitated the formation of uniform SNTs. The stimulus for GDA to be curved into a vesicle was the intermolecular hydrogen bonding between adjacent amide groups of the template molecules. This was illustrated by FTIR spectra of GDA-silica intermediate by detecting the transition of amide I peak from 1678 to 1635 cm. The effect of hydrogen bonding became stronger when the sample was aged.

A Multidimensional Approach to Modulating Ionizable Lipids for High‐Performing and Organ‐Selective mRNA Delivery

“…In the mixture of IL and cholesterol, DSPC and DMG‐PEG in ethanol, the absorptive peak related to the carbonyl of DSPC and the amide of A4I18R2C18‐2 has no changes. But the peak of amide I at 1676 cm −1 was found to shift toward the lower wavenumber and generate a board peak in the formulated LNP, which suggested the formation of characteristic hydrogen bonding of amide bonds between ILs [16] . Then, the particle size and PDI was monitored at 4 °C storage conditions during two months, and the LNP remained no obvious size change with the PDI below 0.2 over time (Figure 2i).…”

“…But the peak of amide I at 1676 cm À 1 was found to shift toward the lower wavenumber and generate a board peak in the formulated LNP, which suggested the formation of characteristic hydrogen bonding of amide bonds between ILs. [16] Angewandte Chemie Then, the particle size and PDI was monitored at 4 °C storage conditions during two months, and the LNP remained no obvious size change with the PDI below 0.2 over time (Figure 2i). This indicates that the bis-amide bonds-containing ILs generated from the Ugi-4CR exhibit the inherent advantage to improve the particle stability of LNPs.…”

Nano-Modified Titanium Implant Materials: A Way Toward Improved Antibacterial Properties

“…Besides, the nanotubes destruction is possible during the separation step from the matrix template so unfortunately, it has poor reproducibility. In the soft template procedure surfactants used as templates ( Bernal et al, 2012 ; Choi et al, 2017 ). Firstly, the surfactant should be mixed with water, titanium alkoxide, and other substances, then the polymerization takes place under certain conditions.…”

Surfactant‐assisted‐water‐exposed versus surfactant‐aqueous‐solution‐exposed electrospinning of novel super hydrophilic polycaprolactone based fibers: Analysis of drug release behavior

“…The exposure distance constitutes the relaxation time of amphiphilic polymer and its related quantity which absorbed to solvents interlayer or entered into water. Pluronic as an amphiphilic polymer can also agglomerate, reassemble and form a myelin layer when solved in non‐aqueous solvents (especially in chloroform) and contacted with water . Resembling mucilage, the Pluronic myelin is visible by the naked eye and remains stable at room temperature.…”

“…Pluronic as an amphiphilic polymer can also agglomerate, reassemble and form a myelin layer when solved in non-aqueous solvents (especially in chloroform) and contacted with water. 10,25 Resembling mucilage, the Pluronic myelin is visible by the naked eye and remains stable at room temperature. Furthermore, when another hydrophobic polymer such as PCL is present in chloroform, chain entanglement between PCL and reassembled Pluronic resides at the interface can retain the myelin layer after fiber formation at its surface.…”