Noxytiolin and peritoneal adhesion formation

Gilmore, O. J. A.; Reid, Clare

doi:10.1002/bjs.1800631224

Cited by 17 publications

(13 citation statements)

References 11 publications

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“…The dispersion in formation of adhesions ( fig. 1, nondialysed animals) repre sents a drawback, but among other clinically relevant animal models the present one seems to be the most suitable in regard to quantitative assess ment of adhesions [2,[6][7][8],…”

Section: Discussionmentioning

confidence: 99%

“…The animal model used in the present study was originally described by Gilmore and Reid [7], and allows a quantitative assessment of adhesions. We modified the model by enlarging the sutured peritoneal defect from 1.4 to 3.0 cm, and our version induced adhesions in all animals and offered a better possibility of measuring the length of attachment of adhesions.…”

Section: Discussionmentioning

confidence: 99%

“…1 cm to the right of the midline. 1 X 3 cm of peritoneum and underlying muscle was excised as described by Gilmore and Reid [7], and the defect then closed with seven atraumatic 3/0 single silk sutures. At this point of the procedure the animals were listed by numbers and randomly allocated to either peritoneal dialysis or a control group.…”

Section: Anesthesia and Surgical Proceduresmentioning

confidence: 99%

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Peritoneal Dialysis Reduces Intraperitoneal Adhesion Formation

Lindenberg¹,

Moesgaard²,

Vangsted³

et al. 1982

Eur Surg Res

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The preventive effect of 24 h intermittent peritoneal dialysis on intra-abdominal adhesion formation was investigated in rats. Intraperitoneal adhesions were induced by excision of 1 × 3 cm of the peritoneum and underlying muscle, subsequently closed with interrupted silk sutures. Animals were allocated at random to either postoperative peritoneal dialysis or a control group. Quantitative assessment of adhesions 1 week later showed a significant reduction in rats undergoing peritoneal dialysis (p < 0.01).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Anesthesia and Surgical Proceduresmentioning

confidence: 99%

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Peritoneal Dialysis Reduces Intraperitoneal Adhesion Formation

Lindenberg¹,

Moesgaard²,

Vangsted³

et al. 1982

Eur Surg Res

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“…The created defect was closed with 6 (5 mm apart) atraumatic 3/0 single silk sutures. This procedure is essentially as described by Gilmore and Reid [11] and later modified by others [15]. After closure of the abdominal incision in two layers the rats were randomly allocated to either treatment with 10ml SAG (50mg) i.p.…”

Section: Experiments 2: Sag Vs Saline On Adhesion Formationmentioning

confidence: 99%

“…Testing of this hypothesis was the second aim of this study. A reliable rat model, initially described by Gilmore and Reid [11] and modified by Lindenberg et al [15] was used, allowing a quantitative assessment of the anti-adhesive effect of SAG.…”

Section: Introductionmentioning

confidence: 99%

Semisoluble aminated glucan: Long-term efficacy against an intraperitonealE. coli challenge and its effect on formation of abdominal adhesions

Seljelid

1987

Res. Exp. Med.

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The first part of this study in the rat was designed to assess the immediate and, in particular, the long-term effects of semisoluble aminated glucan (SAG) with regard to an intraperitoneal (i.p.) E. coli challenge and side-effects. The severity of the E. coli peritonitis was evaluated by quantification of the concomitant bacteremia. The animals randomly received either 10 ml normal saline i.p. (controls) or 10 ml (50 mg) SAG i.p. (experimental groups). It was found that SAG had no immediate protective effect against the infectious challenge as no difference was detected in the bacterial clearance between saline- and SAG-treated rats at day 0. However, 2 days after injection of saline/SAG a substantial protection of SAG was noted as no blood-borne bacteria could be detected at 1, 2, 3, 4 and 5 h after the E. coli challenge in SAG-treated animals, whereas by contrast matching blood cultures were positive in all controls. A likewise protective effect against E. coli bacteremia of a single i.p. injection of SAG was demonstrated at 7, 21, and 49 days after the administration of the compound. During the 7-week experimental period no clinical side-effects of SAG were observed. At autopsy (days 0, 2, 7, 21, and 49, respectively) no gross pathologic conditions were found. Lung, spleen, and kidney sections from SAG-treated rats were normal, whereas tiny granulomas were exhibited in liver sections, possibly related to the hyperfunctional macrophage state which SAG induced. The second main object of the study was to evaluate SAG's effect on adhesion formation.(ABSTRACT TRUNCATED AT 250 WORDS)

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Topical noxythiolin in colonic healing

Rosin

Exarchakos

Gilmore

et al. 1978

Journal of British Surgery

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Rats were subjected to division and anastomosis of the colon just proximal to the rectum to study the healing of colonic anastomoses. The effect of noxythiolin irrigation of the divided colon before and after anastomosis was investigated and compared with controls. Healing was assessed using five variables--macroscopic and microscopic inspection, bursting pressure and tensile strength estimations and angiography for new vessel formation. The study shows that noxythiolin irrigation of the colon in the rat significantly increases the chance of a sound anastomosis without interfering with healing. Furthermore, it inhibits the formation of adhesions.

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Noxytiolin and peritoneal adhesion formation

Cited by 17 publications

References 11 publications

Peritoneal Dialysis Reduces Intraperitoneal Adhesion Formation

Peritoneal Dialysis Reduces Intraperitoneal Adhesion Formation

Semisoluble aminated glucan: Long-term efficacy against an intraperitonealE. coli challenge and its effect on formation of abdominal adhesions

Topical noxythiolin in colonic healing

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