2021
DOI: 10.3389/fimmu.2021.724741
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NPM1 Is a Prognostic Biomarker Involved in Immune Infiltration of Lung Adenocarcinoma and Associated With m6A Modification and Glycolysis

Abstract: BackgroundOverexpression of NPM1 can promote the growth and proliferation of various tumor cells. However, there are few studies on the comprehensive analysis of NPM1 in lung adenocarcinoma (LUAD).MethodsTCGA and GEO data sets were used to analyze the expression of NPM1 in LUAD and clinicopathological analysis. The GO/KEGG enrichment analysis of NPM1 co-expression and gene set enrichment analysis (GSEA) were performed using R software package. The relationship between NPM1 expression and LUAD immune infiltrati… Show more

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Cited by 70 publications
(49 citation statements)
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“…According to Qin et al, NPM1 upregulates PD-L1 transcription and suppresses T-cell activity in triple-negative breast cancer (Qin et al, 2020). In lung adenocarcinoma, NPM1 is also involved in immune infiltration and its expression is closely related to the presence of a variety of immune cells (Liu et al, 2021). Our study also found a significant negative correlation between NPM1 and immune infiltration in patients with ES.…”
Section: Discussionsupporting
confidence: 77%
“…According to Qin et al, NPM1 upregulates PD-L1 transcription and suppresses T-cell activity in triple-negative breast cancer (Qin et al, 2020). In lung adenocarcinoma, NPM1 is also involved in immune infiltration and its expression is closely related to the presence of a variety of immune cells (Liu et al, 2021). Our study also found a significant negative correlation between NPM1 and immune infiltration in patients with ES.…”
Section: Discussionsupporting
confidence: 77%
“…Furthermore, we analyzed the relation between SLC2A1 and immunofiltration cell marker genes in CRC samples utilizing Tumor IMmune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis (GEPIA), and TCGA databases. Immunofiltration marker genes refer to the previous study, in which immune markers of different immune cells are described ( Liu et al, 2021b ).…”
Section: Methodsmentioning
confidence: 99%
“…We downloaded the COAD-related ULBP1 gene mRNA expression data set and the corresponding patient clinical information parameters from the public cancer database-The Cancer Genome Atlas (TCGA, https://tcga-data.nci.nih.gov/ , obtained on December 10, 2020) ( Giordano, 2014 ; Hutter and Zenklusen, 2018 ). Based on the TCGA-COAD project data, the differential expression level of ULBP1 in tumor tissues and adjacent normal tissues in pan-cancers was obtained from the TIMER website ( https://cistrome.shinyapps.io/timer/ , obtained on June 10, 2021) ( Liu et al, 2021 ). The expression level of ULBP1 gene in COAD tumor tissues and adjacent normal tissues was also obtained from the GEPIA website, which integrated the expression levels of normal tissues in the TCGA database and the Genotype-Tissue Expression (GTEx) database.…”
Section: Methodsmentioning
confidence: 99%