NPY mediates reward activity of morphine, via NPY Y1 receptors, in the nucleus accumbens shell

Desai, Sumit; Upadhya, Manoj A.; Subhedar, Nishikant K.; Kokare, Dadasaheb M.

doi:10.1016/j.bbr.2013.03.018

Cited by 35 publications

(18 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As with CRF, NPY is widely expressed in the BNST, but little is known of the behavioral relevance of NPY signaling in the BNST. In other regions of the extended amygdala, NPY signaling promotes anxiolysis (Deo, Dandekar, Upadhya, Kokare, & Subhedar, 2010;Tasan et al, 2010) and reward (Desai, Upadhya, Subhedar, & Kokare, 2013) and relieves aversion (Ide et al, 2013) and depressivelike behaviors (Tasan et al, 2010). In line with observations demonstrating that the behavioral outcomes of NPY activity generally counter those of CRF activity (e.g., anxiolytic vs. anxiogenic, antidepressive vs. prodepressive), NPY signaling was found to functionally oppose CRF's actions on inhibitory transmission in the BNST (Kash & Winder, 2006).…”

Section: Bnst Chemoarchitecture and Major Divisionssupporting

confidence: 64%

The Bed Nucleus of the Stria Terminalis: A Critical Site of Ethanol-Induced Alterations in Neurotransmission

Lowery-Gionta

Kash

2014

Neurobiology of Alcohol Dependence

View full text Add to dashboard Cite

Section: Bnst Chemoarchitecture and Major Divisionssupporting

confidence: 64%

The Bed Nucleus of the Stria Terminalis: A Critical Site of Ethanol-Induced Alterations in Neurotransmission

Lowery-Gionta

Kash

2014

Neurobiology of Alcohol Dependence

View full text Add to dashboard Cite

“…Moreover, rewarding property of AcbSh NPYergic system has been previously observed in our laboratory (Desai et al . ). On the other hand, intra‐AcbSh administration of BIBP3226, NPY Y1 receptor antagonist, decreased ethanol self‐administration into the p‐VTA.…”

Section: Discussionmentioning

confidence: 97%

Neuropeptide Y system in accumbens shell mediates ethanol self-administration in posterior ventral tegmental area

Borkar

Upadhya²,

Shelkar

et al. 2015

Addiction Biology

Self Cite

View full text Add to dashboard Cite

Although modulatory effects of neuropeptide Y (NPY) on ethanol consumption are well established, its role in ethanol reward, in the framework of mesolimbic dopaminergic system, has not been studied. We investigated the influence of nucleus accumbens shell (AcbSh) NPYergic system on ethanol self-administration in posterior ventral tegmental area (p-VTA) using intracranial self-administration paradigm. Rats were stereotaxically implanted with cannulae targeted unilaterally at the right p-VTA and trained to self-administer ethanol (200 mg%) in standard two-lever (active/inactive) operant chamber, an animal model with high predictive validity to test the rewarding mechanisms. Over a period of 7 days, these rats showed a significant increase in the number of lever presses for ethanol self-administration suggesting reinforcement. While intra-AcbSh NPY (1 or 2 ng/rat) or [Leu(31) , Pro(34) ]-NPY (0.5 or 1 ng/rat) dose-dependently increased ethanol self-administration, BIBP3226 (0.4 or 0.8 ng/rat) produced opposite effect. The rats conditioned to self-administer ethanol showed significant increase in the population of NPY-immunoreactive cells and fibres in the AcbSh, central nucleus of amygdala (CeA), hypothalamic arcuate nucleus (ARC) and lateral part of bed nucleus of stria terminalis as compared with that in the naïve rats. Neuronal tracing studies showed that NPY innervations in the AcbSh may derive from the neurons of ARC and CeA. As NPY and dopamine systems in reward areas are known to interact, we suggest that NPY inputs from ARC and CeA may play an important role in modulation of the dopaminergic system in the AcbSh and consequently influence the ethanol induced reward and addiction.

show abstract

“…Additionally, NPY administered centrally or into the NAc shell stimulates dopamine release, which is generally associated with reward [31][32]. NPY administration into the NAc shell can also enhance morphine reward, whereas administration of the NPY Y1 receptor antagonist BIBP 3226 decreases morphine reward [33]. In a recent study, NPY infusion into the NAc shell was found to increase self-administration of ethanol into the posterior ventral tegmental area in rats [34].…”

Section: Discussionmentioning

confidence: 99%

Neuropeptide Y response to alcohol is altered in nucleus accumbens of mice selectively bred for drinking to intoxication

Barkley-Levenson

Ryabinin

Crabbe

2016

Behavioural Brain Research

View full text Add to dashboard Cite

The High Drinking in the Dark (HDID) mice have been selectively bred for drinking to intoxicating blood alcohol levels and represent a genetic model of risk for binge-like drinking. Presently, little is known about the specific genetic factors that promote excessive intake in these mice. Previous studies have identified neuropeptide Y (NPY) as a potential target for modulating alcohol intake. NPY expression differs in some rodent lines that have been selected for high and low alcohol drinking phenotypes, as well as inbred mouse strains that differ in alcohol preference. Alcohol drinking and alcohol withdrawal also produce differential effects on NPY expression in the brain. Here, we assessed brain NPY protein levels in HDID mice of two replicates of selection and control heterogeneous stock (HS) mice at baseline (water drinking) and after binge-like alcohol drinking to determine whether selection is associated with differences in NPY expression and its sensitivity to alcohol. NPY levels did not differ between HDID and HS mice in any brain region in the water-drinking animals. HS mice showed a reduction in NPY levels in the nucleus accumbens (NAc) – especially in the shell – in ethanol-drinking animals vs. water-drinking controls. However, HDID mice showed a blunted NPY response to alcohol in the NAc core and shell compared to HS mice. These findings suggest that the NPY response to alcohol has been altered by selection for drinking to intoxication in a region-specific manner. Thus, the NPY system may represent a potential target for altering binge-like alcohol drinking in these mice.

show abstract

NPY mediates reward activity of morphine, via NPY Y1 receptors, in the nucleus accumbens shell

Cited by 35 publications

References 54 publications

The Bed Nucleus of the Stria Terminalis: A Critical Site of Ethanol-Induced Alterations in Neurotransmission

The Bed Nucleus of the Stria Terminalis: A Critical Site of Ethanol-Induced Alterations in Neurotransmission

Neuropeptide Y system in accumbens shell mediates ethanol self-administration in posterior ventral tegmental area

Neuropeptide Y response to alcohol is altered in nucleus accumbens of mice selectively bred for drinking to intoxication

Contact Info

Product

Resources

About