NRAMP1 Polymorphisms, Susceptibility and Clinical Features of Tuberculosis

Abe, Tomoji; Iinuma, Yoshitsugu; Ando, Masahiko; Yokoyama, Toshinobu; Yamamoto, Tomoko; Nakashima, Kiyotaka; Takagi, Norio; Baba, Hisashi; Hasegawa, Yoshinori; Shimokata, Kaoru

doi:10.1053/jinf.2002.1064

Cited by 46 publications

(40 citation statements)

References 12 publications

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“…In contrast, the subgroup with comorbidity or when the main lesion was neither in the right middle lobe nor the lingular segment, failed to show significant associations with this genotype, although the number of patients are comparable to the other subgroup. Genotypic distribution of these alleles shown in the control is similar to that reported in other Japanese studies [28,29].…”

Section: Pulmonary Mac Infection and Nramp1 Polymorphismssupporting

confidence: 87%

PulmonaryMycobacterium aviumcomplex infection: association withNRAMP1polymorphisms

Tanaka

Shojima²,

Matsushita³

et al. 2007

Eur Respir J

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The present study aimed to elucidate risk factors for nonimmunocompromised pulmonary Mycobacterium avium complex (MAC) infection.Epidemiological data and variations of candidate genes for mycobacterial diseases were analysed in 111 patients with pulmonary MAC infection. Four polymorphisms of the human natural resistance-associated macrophage protein (NRAMP)1 gene, the 59(GT)n, 469+14 G/C, D543N and the 39untranslated region (3'TGTG) insertion/deletion, were genotyped using PCR-based methods. Fok I and Taq I polymorphisms of the vitamin D receptor gene and -221 X/Y and codon 54 A/B polymorphisms of the mannose binding lectin gene were also evaluated.Females were more susceptible to MAC infection mainly affecting the right middle lobe or lingular segment of the lung. Patients' residence at the onset of the disease was distributed evenly irrespective of a waterfront or city water supply system. As compared with homozygotes for major alleles of the D543N and TGTG insertion/deletion polymorphism of the NRAMP1 gene, heterozygotes containing minor alleles were less often observed in MAC cases than in controls. This genetic effect was more significant in patients without comorbidity but not in patients with comorbidity. Other polymorphisms did not show any association with the MAC infection.The human natural resistance-associated macrophage protein 1 gene might be involved in susceptibility to pulmonary Mycobacterium avium complex infection.

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Section: Pulmonary Mac Infection and Nramp1 Polymorphismssupporting

confidence: 87%

PulmonaryMycobacterium aviumcomplex infection: association withNRAMP1polymorphisms

Tanaka

Shojima²,

Matsushita³

et al. 2007

Eur Respir J

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“…This finding dosen't confirm a previous investigation in West Africans, the four NRAMP1 variants, namely the 3'UTR deletion, D543N, INT4 and 5'(GT), were found to be significantly associated with TB (29). In studies of Asian subjects, the results have been inconsistent (18,(30)(31)(32)(33), and in Koreans, only the D543N and 3'UTR variants were associated with susceptibility to TB (18). However, in Cambodians, the D543N and 3'UTR variants were associated with resistance to TB (30).…”

Section: Discussioncontrasting

confidence: 75%

“…Some studies have shown associations only with the severe forms of TB, but not with susceptibility to TB. In Japanese subjects, the D543N variant, but not the INT4 variant, was associated with the presence of cavity lesions, whereas in Chinese subjects, the D543N and INT4 variants were associated with more severe forms of TB (32,33). In the Thai population, there was no association of the INT4, D543N or 3'UTR variants with susceptibility to TB, or with the severe form of TB.…”

Section: Discussionmentioning

confidence: 79%

Polymorphisms in NRAMP1 and MBL2 genes and their relations with tuberculosis in Turkish children

Solgun

Taştemir²,

Aksaray³

et al. 2011

Tuberk Toraks

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“…The role of the Nramp1 gene in human immune defense and susceptibility to infection is not as clear-cut as in the mouse. While an association between polymorphisms in Nramp1 and susceptibility to tuberculosis or leprosy has been demonstrated in some studies, it has not been replicated in others, and the effect may be restricted to specific populations or geographic areas [36,37] .…”

Section: Expression Of Macrophage Iron Transportersmentioning

confidence: 98%

Ironing Out the Wrinkles in Host Defense: Interactions between Iron Homeostasis and Innate Immunity

Wang

Cherayil

2009

J Innate Immun

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Iron is an essential micronutrient for both microbial pathogens and their mammalian hosts. Changes in iron availability and distribution have significant effects on pathogen virulence and on the immune response to infection. Recent advances in our understanding of the molecular regulation of iron metabolism have shed new light on how alterations in iron homeostasis both contribute to and influence innate immunity. In this article, we review what is currently known about the role of iron in the response to infection.

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NRAMP1 Polymorphisms, Susceptibility and Clinical Features of Tuberculosis

Cited by 46 publications

References 12 publications

PulmonaryMycobacterium aviumcomplex infection: association withNRAMP1polymorphisms

PulmonaryMycobacterium aviumcomplex infection: association withNRAMP1polymorphisms

Polymorphisms in NRAMP1 and MBL2 genes and their relations with tuberculosis in Turkish children

Ironing Out the Wrinkles in Host Defense: Interactions between Iron Homeostasis and Innate Immunity

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