A commercially available enzyme immunoassay developed to detect antibodies to a tuberculosis-associated glycolipid antigen was evaluated for serologic diagnosis of tuberculosis. This was a multicenter study comparing the assay with other methods in 78 patients with active pulmonary tuberculosis and in 54 controls with non-tuberculous lung diseases. Sensitivities were highest for sputum culture (91.0%), followed by immunoassay (79.5%), nucleic acid amplification (77.3%), and finally acid-fast staining of sputum smear (60.3%). Immunoassay and amplification, both rapid methods, had similarly high sensitivity in smear-positive subjects (89.4 and 88.9%, respectively); in smear-negative subjects these two techniques showed low sensitivity (64.5 and 60.0%, respectively). Concordance between the two methods was relatively low (72.0%). With regard to specificity, seven out of ten patients with old tuberculosis had positive result by immunoassay (30% specificity). In the control group, 10 out of 54 patients had positive immunoassay result (72.2% specificity), with notably limited specificity in the elderly. The tuberculous glycolipid assay is a rapid method sufficiently sensitive for detection of tuberculosis infection, even in smear-negative patients. Clin Chem Lab Med 2002; 40(8):832-836
Background. In the case of resected multiple pulmonary metastases from gastric and colon cancer, it was difficult to differentiate the pulmonary metastases from primary cancer. Case. A 62-year-old woman underwent subtotal gastrectomy and hemicolectomy because of gastric and the colon cancer. Eighteen months later, she was found to have a pulmonary nodule in the left upper lobe on a chest computed tomography (CT). She underwent left upper lobectomy because the tumor was not diagnosed by the frozen microscopic findings. The tumor was diagnosed as a lung metastasis from colon cancer pathologically. She was found to have an another pulmonary nodule in the right upper lobe on the follow up CT scan. She underwent right upper lobectomy and the tumor was diagnosed as lung metastases from gastric cancer. Conclusion. We report a case of multiple metastases from gastric cancer and colon cancer.
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