Nuclear Factor [Erythroid-derived 2]-like 2 and Mitochondrial Transcription Factor A Contribute to Moderate-intensity Swimming Effectiveness against Memory Impairment in Young Mice Induced by Concomitant Exposure to a High-calorie Diet during the Early Life Period

Jardim, Natália Silva; Müller, Sigrid; Pase, Flávia Matos; Nogueira, Cristina Wayne

doi:10.1016/j.neuroscience.2020.11.023

Cited by 2 publications

(2 citation statements)

References 60 publications

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“…The mash was manually shaped in pellets, dried overnight on a laboratory oven at 28°C and stored in sealed plastic bags at –20°C until use. The commercial diet macronutrient composition (carbohydrate 40.5%; protein 16.2%; lipids 1.5%) was obtained from the manufacturer 19 …”

Section: Methodsmentioning

confidence: 99%

Swimming training mitigates the sex‐specific hepatic disruption caused by a high‐calorie diet: The putative modulation of Nrf2/Keap‐1 pathway in male mice

Jardim

Müller

Nogueira

2021

Cell Biochemistry & Function

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This study investigated whether swimming protocol induces adaptations to sex‐specific oxidative stress and Nrf2/Keap‐1 pathway in the liver of mice fed a high‐calorie diet (HCD) during the early life period. Male and female Swiss mice were fed a standard or high‐calorie (enriched with 20% lard and 20% corn syrup) diets, and the trained mice were subjected to a swimming protocol (5 days/week) from 21st to 49th postnatal days. Males fed a HCD had more pronounced alterations in all parameters evaluated than females. Although there was no increase in body weight, the fat deposition was higher in male mice exposed to diet. The intake of HCD induced dyslipidemia mainly in males. In a sex‐dependent manner, the hepatic markers of oxidative damage, antioxidant defences, and a sensitive sulfhydryl protein were altered in mice fed a HCD. Swimming counteracted dyslipidemia, hepatic oxidative stress, and the Nrf2/Keap‐1 signalling downregulation, in a sex‐dependent manner, in mice exposed to a HCD. These findings demonstrate that a non‐pharmacological therapy, swimming protocol, contributed to adaptations of sex‐specific hepatic oxidative stress and Nrf2/Keap‐1 regulation in male mice fed a HCD.

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Section: Methodsmentioning

confidence: 99%

Swimming training mitigates the sex‐specific hepatic disruption caused by a high‐calorie diet: The putative modulation of Nrf2/Keap‐1 pathway in male mice

Jardim

Müller

Nogueira

2021

Cell Biochemistry & Function

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“…Following cellular stresses, the NRF2 pathway is activated to stimulate defence mechanisms, reduce body weight, and increase energy expenditure. Jardim and colleagues recently described that young mice, exposed to a high-caloric diet during their early-life period, had learning and memory impairments [ 154 ]. The authors revealed that this specific diet induced an oxidative stress in the hippocampus, a brain region known to have critical functions in cognition and memory but also to play certain roles in regulating food intake [ 155 ].…”

Section: Nrf2 and Brain (Dys)functionsmentioning

confidence: 99%

Normal and Pathological NRF2 Signalling in the Central Nervous System

et al. 2022

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The nuclear factor erythroid 2-related factor 2 (NRF2) was originally described as a master regulator of antioxidant cellular response, but in the time since, numerous important biological functions linked to cell survival, cellular detoxification, metabolism, autophagy, proteostasis, inflammation, immunity, and differentiation have been attributed to this pleiotropic transcription factor that regulates hundreds of genes. After 40 years of in-depth research and key discoveries, NRF2 is now at the center of a vast regulatory network, revealing NRF2 signalling as increasingly complex. It is widely recognized that reactive oxygen species (ROS) play a key role in human physiological and pathological processes such as ageing, obesity, diabetes, cancer, and neurodegenerative diseases. The high oxygen consumption associated with high levels of free iron and oxidizable unsaturated lipids make the brain particularly vulnerable to oxidative stress. A good stability of NRF2 activity is thus crucial to maintain the redox balance and therefore brain homeostasis. In this review, we have gathered recent data about the contribution of the NRF2 pathway in the healthy brain as well as during metabolic diseases, cancer, ageing, and ageing-related neurodegenerative diseases. We also discuss promising therapeutic strategies and the need for better understanding of cell-type-specific functions of NRF2 in these different fields.

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Nuclear Factor [Erythroid-derived 2]-like 2 and Mitochondrial Transcription Factor A Contribute to Moderate-intensity Swimming Effectiveness against Memory Impairment in Young Mice Induced by Concomitant Exposure to a High-calorie Diet during the Early Life Period

Cited by 2 publications

References 60 publications

Swimming training mitigates the sex‐specific hepatic disruption caused by a high‐calorie diet: The putative modulation of Nrf2/Keap‐1 pathway in male mice

Swimming training mitigates the sex‐specific hepatic disruption caused by a high‐calorie diet: The putative modulation of Nrf2/Keap‐1 pathway in male mice

Normal and Pathological NRF2 Signalling in the Central Nervous System

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