“…In addition, prolonged NF-κB activation has been detected in various diseases, including atherosclerosis 4,19) . In fact, inflammation plays a role in all stages of atherosclerosis 4) , and various targets of NF-κB are known to be involved in the initiation and progression of atherosclerosis 20) . Furthermore, SAA has been shown to induce the expression of the pro-inflammatory cytokine, IL-8, as mediated via IκB degradation and NF-κB activation 21) .…”