2010
DOI: 10.1016/s1734-1140(10)70338-8
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Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB): a new potential therapeutic target in atherosclerosis?

Abstract: Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a crucial transcription factor that participates in a number of physiological and pathological conditions, including immune response, apoptosis, carcinogenesis and inflammatory processes. It is involved in the rapid response to various stimuli such as viral and bacterial infections, shear stress, oxidant stress and a number of cytokines. In the pathology of atherosclerosis NF-κB is essential to the cross-talk between cytokines, adhesion … Show more

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Cited by 67 publications
(42 citation statements)
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“…Macrophages play an important role in all stages of atherosclerosis, and unstable plaques, present in patients with acute coronary syndrome, are primarily composed of macrophages 16) . Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of nuclear transcription factors responsible for the regulation of a wide range of genes, such as those involved in inflammation and apoptosis 4) . NF-κB is activated by various stimuli, including cytokines and tumor necrosis factor α (TNF-α), with activation being both rapid and shortlasting 4,17) .…”
Section: Quantitative Real-time Pcrmentioning
confidence: 99%
See 3 more Smart Citations
“…Macrophages play an important role in all stages of atherosclerosis, and unstable plaques, present in patients with acute coronary syndrome, are primarily composed of macrophages 16) . Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of nuclear transcription factors responsible for the regulation of a wide range of genes, such as those involved in inflammation and apoptosis 4) . NF-κB is activated by various stimuli, including cytokines and tumor necrosis factor α (TNF-α), with activation being both rapid and shortlasting 4,17) .…”
Section: Quantitative Real-time Pcrmentioning
confidence: 99%
“…Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of nuclear transcription factors responsible for the regulation of a wide range of genes, such as those involved in inflammation and apoptosis 4) . NF-κB is activated by various stimuli, including cytokines and tumor necrosis factor α (TNF-α), with activation being both rapid and shortlasting 4,17) . SAA has also been found to stimulate NF-κB activation 18) .…”
Section: Quantitative Real-time Pcrmentioning
confidence: 99%
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“…Recent evidence supports selective recruitment of a proinflammatory subset of monocytes to nascent atheroma in mice (Packard & Libby, 2008). A number of proinflammatory cytokines have been shown to participate in atherosclerotic plaque development, growth and rupture (Dabek, 2010;Libby et al, 2002). Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) seems to be a crucial transcription factor in the cross-talk among cytokines, adhesion molecules and growth factors.…”
Section: Atherosclerosis and Inflammationmentioning
confidence: 99%